Phenotype Databases

Selected news for the healthcare topic - Phenotype Databases, collected since 8/2019. We are still establishing shared news links for this healthcare topic.

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8/23/2019 Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits Nature ... detect significant expression-trait associations. Joint analysis of 14 large-scale transcriptome datasets and 58 traits identify 13,724 significant expression-trait associations that converge on biological processes and relevant phenotypes in human and mouse phenotype databases . We perform drug repurposing analysis and identify compounds that mimic, or reverse, trait-specific changes. We identify genes that exhibit agonistic pleiotropy for genetically correlated traits that converge on shared biological pathways and elucidate ...