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|Date||Headline (link)||Source||Relevant Snippet|
|8/23/2019||Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits||Nature||... detect significant expression-trait associations. Joint analysis of 14 large-scale transcriptome datasets and 58 traits identify 13,724 significant expression-trait associations that converge on biological processes and relevant phenotypes in human and mouse phenotype databases . We perform drug repurposing analysis and identify compounds that mimic, or reverse, trait-specific changes. We identify genes that exhibit agonistic pleiotropy for genetically correlated traits that converge on shared biological pathways and elucidate ...|