Pharmacogenomic Analysis

Selected news for the healthcare topic - Pharmacogenomic Analysis, collected since 4/2019. We are still establishing shared news links for this healthcare topic.

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2/8/2021 WCLC 2020 | ITACA pharmacogenomic adjuvant chemotherapy approach does not boost resected NSCLC outcomes medwirenews.com ... University of Turin, Italy) reported the ITACA study findings showing no difference in overall survival (OS) or recurrence-free survival (RFS) when patients with stage II–IIIA NSCLC were given adjuvant chemotherapy based on pharmacogenomic analysis or a control regimen consisting of an investigator’s choice of cisplatin-based doublet chemotherapy.Advertisement The 773 patients were all assessed for mRNA expression levels of the excision repair cross complementation 1 ( ERCC ...
1/13/2021 Mayo Clinic London hires operations director laingbuissonnews.com ... with personalised health plans aimed at both individual and corporate clients.Under its new ownership, the clinic began to provide second opinions across all medical conditions and specialties as well as offering genomic and pharmacogenomic analysis , Covid-19 testing and other screening capabilities. TAGS ...
12/15/2020 Add-On HDAC Inhibitor No Help in Breast Cancer medpagetoday.com Add-On HDAC Inhibitor No Help in Breast Cancer — PFS, OS similar to endocrine therapy alone for advanced HR+ disease by Charles Bankhead , Senior Editor, MedPage Today December 15,Survival in advanced hormone receptor (HR)-positive breast cancer did not improve with the addition of a histone deacetylase (HDAC) inhibitor to standard endocrine therapy, according to a randomized trial.Median progression-free survival (PFS) improved from 3.1 to 3.3 ...
3/10/2020 MicroRNA-mRNA networks define translatable molecular outcome phenotypes in osteosarcoma Nature ... of candidate microRNA signatures and contextualized them in relevant transcriptomic and epigenomic networks. Our results reveal the existence of molecularly defined phenotypes associated with outcome independent of clinicopathologic features. Through machine learning based integrative pharmacogenomic analysis , the microRNA biomarkers identify novel therapeutics for stratified application in osteosarcoma. The previously unrecognized osteosarcoma subtypes with distinct clinical courses and response to therapy could be translatable for discerning patients appropriate for more intensified ...
11/26/2019 Pharmacogenomic analysis of patient-derived tumor cells in gynecologic cancers biomedcentral.com Gynecologic malignancy is one of the leading causes of mortality in female adults worldwide. Comprehensive genomic analysis has revealed a list of molecular aberrations that are essential to tumorigenesis, progression, and metastasis of gynecologic tumors. However, targeting such alterations has frequently led to treatment failures due to underlying genomic complexity and simultaneous activation of various tumor cell survival pathway molecules. A compilation of molecular characterization of tumors with pharmacological drug ...
10/4/2019 Patients Driving Need for Psychiatrists to Learn More About Genetics psychcongress.com ... treatment remains a work in progress, Indiana University Professor of Medicine John Nurnberger Jr., MD, PhD, said at Psych Congress 2019 . Still, Dr. Nurnberger told a session audience that genetic research evidence, particularly in pharmacogenomic analysis of medication options, continues to grow more positive. While it may be too soon to recommend routine ordering of patient genetic tests for diagnosing a disorder or prescribing a treatment, many potential applications merit ...
9/3/2019 Creating reproducible pharmacogenomic analysis pipelines Nature Article" lang="en" Full size table Tracking Data Provenance and Validating Pipeline Integrity Tracking data provenance with CWL can be further enhanced through the use of the provenance flag (–provenance) when executing the PSet workflows 11 . Here, a Research Object is automatically generated, which is a directory that acts as a bundled container for all of the resources utilized and produced within our workflows, including metadata that annotates each resource ...
4/19/2019 Creating reproducible pharmacogenomic analysis pipelines biorxiv.org Creating reproducible pharmacogenomic analysis pipelines Anthony Mammoliti , Petr Smirnov , Zhaleh Safikhani , Wail Ba-Alawi , Benjamin Haibe-Kains doi: https://doi.org/10.1101/614560 The field of Pharmacogenomics presents great challenges for researchers that are willing to make their studies reproducible and shareable. This is attributed to the generation of large volumes of high-throughput multimodal data, and the lack of standardized workflows that are robust, scalable, and flexible to perform large-scale ...