Gut Microbiome

The Interplay Between Host Genetics and the Gut Microbiome Reveals Common and Distinct Microbiome Features for Complex Human Diseases | 10/13/2020

Urban Health Today Home Abstracts The Interplay Between Host Genetics and the Gut Microbiome Reveals Common and… The Interplay Between Host Genetics and the Gut Microbiome Reveals Common and Distinct Microbiome Features for Complex Human Diseases October 12, 2020 Print Background Interest in the interplay between host genetics and the gut microbiome in complex human diseases is increasing, with prior evidence mainly being derived from animal models. In addition, the …

5 easy, delicious weeknight dinners that are also great for your gut. | MSN | 10/13/2020

… too easy to fall deep into comfort, instead of nutrition. In a nutshell: we are stressed out, eating more, moving less and I, for one, am feeling sluggish. “Psychological and emotional stress can affect gut microbiome balance,” Mikhaila Todd, Certified Integrative Nutrition Health Coach, specialising in gut health, tells Mamamia. “And when your gut is unhealthy, your whole body is at risk.” Mikhaila explains: “The digestive, immune, nervous, and endocrine …

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Are Peptides Legal? What The FDA’s New Bulk Drug Substance Crackdown Means For Peptides (Plus 9 Promising Little-Known Peptides To Watch Out For In The Future). | 10/13/2020

… attributed to increased intestinal paracellular permeability even though scientific evidence supporting this hypothesis has been unsubstantiated. Nevertheless, during the past decade, there have been a growing number of publications focused on human genetics, the gut microbiome , and proteomics suggesting that loss of mucosal barrier function (particularly in the gastrointestinal tract) may substantially affect antigen trafficking—ultimately causing chronic inflammation, including autoimmunity in genetically predisposed individuals. The gut mucosa works as …

Prebiotics: Not Only For Gut Health? | 10/13/2020

… of oral prebiotics needs more research, we can consider the ways prebiotics can help our oral health in an indirect way. For example, pathogens associated with periodontal disease may be capable of altering the gut microbiome . Specifically, P.ginigvalis, a pathogen implicated in periodontal disease, was found to provoke dysbiosis of the gut microbiome . 5 Dysbiosis is a term used to describe when there is an imbalance in the microbial communities …

Autism’s Gut Connection: Microbes Could Soon Lead to New Treatments | 10/13/2020

… sometimes anxiety and aggression. The causes of the brain disorder have remained speculative. Now, Mazmanian and other researchers are finding that autism may be inextricably linked to — or even caused by — irregularities in the gut microbiome . A Biology Story At 47, Mazmanian — with his shaved head, flannel shirt and skinny jeans — resembles a young, urban hipster on his way to write at the local café. Originally, literary life was his …

Viscera-3 Reviews – Does SANE Viscera-3 Really Work or Scam? | 10/13/2020

… amounts, you can check out the label of the supplement. As per the manufacturers, the groundbreaking formula is the first of its kind to promote gut healing, preventing leaky gut and promoting a healthy gut microbiome . The 4 proven nutrients present in Viscera-3 pills are known for this and more. For instance, they also enhance your mental wellbeing and curtail inflammation. All this gives you great health on the …

** | 10/12/2020**

… various dosing and pre-treatment regimens. “People living with inflammatory bowel disease often struggle to find lasting relief with currently available medications. Our defined bacterial consortia are designed to reshape the ecosystem of the gut microbiome , an aspect of inflammatory bowel disease (IBD) that has not been addressed by biologics and other existing drug classes,” said Bernat Olle, Ph.D., co-founder and chief executive officer of Vedanta Biosciences. “We are …

Vedanta Biosciences Announces Additional Pharmacokinetics Data From Phase 1 Study of VE202 for Inflammatory Bowel Disease to Be Presented at United European Gastroenterology Week 2020 | BioSpace | 10/12/2020

… various dosing and pre-treatment regimens. “People living with inflammatory bowel disease often struggle to find lasting relief with currently available medications. Our defined bacterial consortia are designed to reshape the ecosystem of the gut microbiome , an aspect of inflammatory bowel disease (IBD) that has not been addressed by biologics and other existing drug classes,” said Bernat Olle, Ph.D., co-founder and chief executive officer of Vedanta Biosciences. “We are …

ZnO and TiO 2 nanoparticles alter the ability of Bacillus subtilis to fight against a stress | 10/12/2020

… Bacillus subtilis to fight against a stress. Bacteria have been exposed to sublethal doses of nanoparticles corresponding to conditions that bacteria may meet in their natural biotopes, the upper layer of soil or the gut microbiome . The analysis of the proteomic data obtained by shotgun mass spectrometry have shown that several metabolic pathways are affected in response to nanoparticles, n-ZnO or n-TiO 2 , or zinc salt: the methyglyoxal …

Bacteriophages: A Novel Concept in Probiotics! | 10/12/2020

… are tiny organisms that make your probiotic stronger and more effective. One of the most exciting uses for bacteriophages has to do with gut health. [1 , 2] They boost the good microbes in your gut microbiome (also known as gut flora) and deter the harmful ones. This allows for better gut balance. When you have a healthy gut, it influences many other aspects of your health, from your mind to …

The aging mouse microbiome has obesogenic characteristics | 10/12/2020

During aging, there is a physiological decline, an increase of morbidity and mortality, and a natural change in the gut microbiome . In this study, we investigated the influence of the gut microbiome on different metabolic parameters in adult and aged mice. Methods Fecal and blood samples from adult ( n  = 42, 100–300 days) and aging ( n  = 32, 550–750 days) mice were collected. Microbiome analysis was done using QIIME2. Mouse …

Dr. Joel Gould, DDS Releases eBook “The Modern Epidemic” | 10/12/2020

… and the terrifying syndrome resulting from Vitamin D deficiency, which Gould has named “The Modern Epidemic.” This interactive, multimedia eBook defines and clarifies a different medical paradigm based on vitamin D deficiency and the gut microbiome . The eBook’s message is that humans evolved here on Earth to be “Hunter Gatherers,” but we live in the modern world, which is a poor match for our environmentally sensitive bodies. The eBook urges …

Reduced Fecal Acidity Mirrors Rise in Celiac Rates | 10/12/2020

… health. We know that the gut microbiota of children begin to change when they get celiac disease . Low levels of certain gut bacteria correspond with higher rates of celiac disease. We also know that gut microbiome s of children with a high genetic risk for type 1 diabetes are significantly different than those of children with low genetic risk . Moreover, changing gut microbiota could protect against celiac disease . However, there’s much …

Gunk from medieval baths revealed that people were suffering from parasites | 10/11/2020

… bowels of an entire community. Think of all those TV commercials that relentlessly insist on probiotics for gut health. Probiotics might be trending, in both pill and yogurt form, but they help balance the gut microbiome , everything that lives in your gut. Scientists have now been able to find out what was hiding in the microbiomes of two cities during the 14th and 15th centuries, and it’s ugly. Parasites thrive …

Gut Microbiome Testing for Weight Loss & Health | Viome | 10/11/2020

… way to feeling better, losing weight, getting better sleep, eliminating brain fog and having more energy! NEW World’s first Health Intelligence™ Test Find out more Get precise food and supplement recommendations based on your gut microbiome , cellular & mitochondrial health. $599 USD …

Reversing Arthritis with a Personalized Diet | Viome | 10/11/2020

… start the company, so we can help millions of other people. By the beginning of 2015, my path to begin Viome was already set. I knew that working to prevent chronic diseases through the gut microbiome was the next chapter of my life – but I had personal health issues that were detracting from my work and personal life. I had been struggling with arthritis for about 20 years – from the …

How to Heal Arthritis Naturally – Experience Life | 10/11/2020

… sugars, animal foods from feedlot cows, etc. The world is moving faster with technology, and people are sleeping less, productivity is higher, and people are more stressed. This directly harms the immune system. Our gut microbiome s are a mess. EL Most people don’t associate gut problems with arthritic pain in the knees or hands. Can you explain this? SB Let’s start with the 100 trillion bacteria in the gut that …

Kids Immune Balance | 10/11/2020

… adequate food to strengthen their defenses and create a natural barrier against infection. Gut Connection Kids Immune Balanc e is a tasty animal-shaped chewable. Help support a strong & healthy immune system and improve gut microbiome health. Through food, all the nutrients required for the proper functioning of the immune system enter the body: a vital part of the “defenses” is concentrated in the intestine, and its proper functioning is …

Maintaining Kid’s Immune & Gut Health with Country Life | 10/11/2020

Maintaining Kid’s Immune & Gut Health with Country Life Sunday, October 11, 2020 I received this product for free from Moms Meet to use and post my honest opinions. Compensation for this post was provided and this page may contain affiliate links. The gut microbiome is home to trillions of bacteria, so it’s no secret that feeling great from the inside out starts with the gut. With a mission to connect …

Have you ever heard of this healthy alternative to flour? | 10/11/2020

… tropics for centuries Breadfruit flour could reduce exposure to gluten in baked products; it could also mitigate diabetes and help with food shortages around the world High fiber in breadfruit helps to feed the gut microbiome ; it may prevent leaky gut syndrome and lower the risk of heart disease Have you ever heard of breadfruit? It’s a rather strange name for a piece of fruit that sounds like it may …

Gut Health is the Key to a Healthy Life | 10/10/2020

… we talked about, in a publication, that’s well-respected we talked about how the gut microbiota and COVID-19 could be what could be linked, right? So it’s very important to know that the gut microbiome and many of you may know what that is. The gut microbiome is where basically all the trillions of bugs that are in your intestinal system and how they can affect your health. We …

Archaeologists unearth Medieval poop that might hint at what a healthy gut microbiome looks like | 10/10/2020

Archaeologists unearth Medieval poop that might hint at what a healthy gut microbiome looks like Friday, October 09, 2020 by: Virgilio Marin Bypass censorship by sharing this link: https://www.clearnewswire.com/463597.html ( Natural News ) Medieval fecal samples from Israel and Latvia could provide crucial insights into how gut diseases developed , suggests a recent study published in the journal Philosophical Transactions of the Royal Society B . The samples were recovered from …

Rationale and design of a randomised controlled trial testing the effect of personalised diet in individuals with pre-diabetes or type 2 diabetes mellitus treated with metformin | BMJ | 10/10/2020

… glycaemic response (PPGR) to meals. The algorithm incorporates the individual’s personal data (eg, age, gender, body mass index (BMI)), blood tests (eg, glycated haemoglobin (HbA1c)), dietary features, continuous glucose monitor (CGM)-derived data and gut microbiome features, and trained on data previously collected in 800 individuals. Personally tailored dietary plans based on the algorithm were trialled in a small group of individuals with pre-diabetes and shown to improve glycaemic …

Google Alert - register | 10/8/2020

register As-it-happens update ⋅ October 8, 2020 NEWS The Gut Microbiome : Register NOW for today’s session at 14:00 BST NutraIngredients.com Register to watch. The day’s proceedings round off with a panel discussion with the three presenters that gives our experts an opportunity to debate the … Flag as irrelevant Some Southeast Texans who registered to vote did not need to re- registered KFDM-TV News BEAUMONT — The deadline to register …

Not known Details About multivitamin for men | 10/8/2020

Not known Details About multivitamin for men Not known Details About multivitamin for men Category: Blog The microorganisms that Stay within your gut microbiome are associated with digestive health, cognition, temper, along with your immune procedure. Things like diet plan, training and anxiety all disrupt your microbiome and may lead to a number of troubles.Gummy vitamins are similar to jelly candies with regards to their overall look and regularity. These …

COVID-19

Is there a vegetarian way to do the ketogenic diet? | MSN | 9/21/2020

… Buzz60 Hear from nurse who shared shocking weight loss photos CNN A look at the potential long term effects of Covid-19 CNN Wearing surgical mask may reduce COVID-19 infections up to 75% Veuer … But a traditional keto diet may be beneficial to the gut microbiome in some ways, according to a recent small study published the May 2020 issue of Cell . Researchers tracked microbial shifts related to the …

Human Microbiome

Could social distancing actually make the coronavirus pandemic worse? | 9/18/2020

Researchers say continuing to socially distance may weaken the human microbiome , making people more vulnerable to future infections. A team in Portugal is reviewing what they call the “double-edged sword” of social distancing. They find there are two critical ways this practice during the pandemic may be helping and harming the gut microbiome. “Our behaviors have consequences,” lead author Teresa Nogueira says in a media release . “We are doing …

Clinical Research

Protocol of a multicenter, single-blind, randomised, parallel controlled feeding trial evaluating the effect of a Chinese Healthy Heart (CHH) diet in lowering blood pressure and other cardiovascular risk factors | BMJ | 8/20/2020

… effect of a Chinese Healthy Heart (CHH) diet in lowering blood pressure and other cardiovascular risk factors 1 Peking University Clinical Research Institute, Peking University First Hospital , Beijing , China 2 Peking University Clinical Research Institute … We will investigate the effect of the CHH diet on gut microbiome in this trial and the results might provide additional information linking the healthy diet and health outcomes. The food nutrients in the CHH …

CDC

Protocol of a multicenter, single-blind, randomised, parallel controlled feeding trial evaluating the effect of a Chinese Healthy Heart (CHH) diet in lowering blood pressure and other cardiovascular risk factors | BMJ | 8/20/2020

… China 8 State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, China CDC , Beijing , China 9 Department of Medicine , Nephrology Division, Duke University Medical Center , Durham , North … We will investigate the effect of the CHH diet on gut microbiome in this trial and the results might provide additional information linking the healthy diet and health outcomes. The food nutrients in the CHH …

CRISPR

Evogene Reports Second Quarter 2020 Financial Results | PR Newswire | 8/5/2020

… capabilities and expand into new market segments. To that end, during this second quarter, Evogene announced its participation in the CRISPR-IL consortium to provide an end-to-end artificial intelligence system for genome-editing … studies [2] that fecal microbiota transplants (FMT), altering the patient’s gut microbiome, have the potential to improve the response rates to immunotherapy. Through the use of Evogene’s MicroBoost AI solution, Biomica is discovering and developing …

Food and Drug Administration

Synthetic Biologics Announces FDA Clearance of Investigational New Drug Application for SYN-020 Intestinal Alkaline Phosphatase (IAP) | PR Newswire | 7/30/2020

… in areas of high unmet need, today announced that it has received a study-may-proceed letter from the U.S. Food and Drug Administration (FDA) for the first clinical study of SYN-020, an oral … to reduce the impact of methane-producing organisms in the gut microbiome to treat an underlying cause of irritable bowel syndrome with constipation (IBS-C). The Company is also advancing SYN-020, an oral formulation …

Ohio State University

Evolve BioSystems, Inc. announces Dr. Minhthy Nguyen as Senior Vice President of Research & Development, further advancing its position as the leader in infant gut health | PR Newswire | 7/28/2020

… Nguyen is a graduate of University of California, Davis , where he earned a BS in Biochemistry, as well as The Ohio State University where he earned his doctorate in Food Science and Nutrition. “I am … to researching solutions to establish, restore, and maintain a healthy gut microbiome. Evolve is a portfolio company of the Bill & Melinda Gates Foundation and Horizons Ventures, the venture division of the Li Ka Shing Foundation …

Medical Research

Study protocol for a 9-month randomised controlled trial assessing the effects of almonds versus carbohydrate-rich snack foods on weight loss and weight maintenance | BMJ | 7/20/2020

… 4 Institute for Physical Activity and Nutrition (IPAN) , Deakin University , Burwood , Victoria , Australia 5 Microbiome Research , South Australian Health and Medical Research Institute (SAHMRI) , Adelaide , South Australia , Australia 6 College of Medicine and Public Health … via doubly labelled water), physical activity, appetite regulation, cardiometabolic health, gut microbiome, liver health, inflammatory factors, eating behaviours, mood and personality, functional mobility and pain, quality of life and sleep patterns will be measured throughout …

Biotech

Ex-GSK Shingrix chief Guillaume Pfefer lands at Flagship as its second CEO-partner | FierceBiotech | 7/17/2020

It’s back to biotech for Guillaume Pfefer, Ph.D., and not a moment too soon. Having spent four years at GlaxoSmithKline ushering its shingles vaccine through approval and onto the market, he’s now taking on the … an adviser. RELATED: Kintai’s obesity drug that works via the gut microbiome moves closer to the clinic One of its leading programs targets the gut microbiome to treat obesity. In January this year, the company …

Tufts University

Summit Announces Publication of Phase 2 Clinical Analyses of Gut Microbiome Health | Globe Newswire | 7/13/2020

Gut Microbiome Health Oxford, UK, and Cambridge, MA, US, July 13, 2020 – Summit Therapeutics plc (NASDAQ: SMMT) today announces the publication of data from the Phase 2 clinical trial of the company’s precision antibiotic, ridinilazole, in development for the treatment of C. difficile infection (‘CDI’) in the American Journal of Physiology – Gastrointestinal and Liver Physiology . The data published in collaboration with researchers at Tufts University and Tufts Medical Center demonstrated …

NIDDK

Latest TEDDY Report Outlines Research on Type 1 Diabetes and Celiac Disease | PR Newswire | 6/15/2020

… potential causes T1D in children. The study is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). T1D occurs when the beta cells of the pancreas that normally make insulin are … are also subtle differences in the composition and function of gut microbiome in children who develop islet autoantibodies, compared to controls. Early use of probiotics may decrease the risk, while use of antibiotics was not …

The Ohio State University

Danone North America Awards $50,000 in Student Grants to Further Yogurt and Gut Microbiome Exploration | PR Newswire | 4/28/2020

WHITE PLAINS, N.Y. and BROOMFIELD, Colo. , April 28, For the eighth year in a row, Danone North America has demonstrated their commitment to science and education through the Danone Gut Microbiome, Yogurt and Probiotics Fellowship Grant Program. This year’s honorees are Erica Kosmerl of The Ohio State University and Elizabeth Morrison of Indiana University . A committee of nutrition scientists selected the two winners based on the quality of their proposals …

National Institutes of Health

‘Dead’ Probiotic Bacteria Could Help Ease Irritable Bowel - U.S. News & World Report | 4/9/2020

… more practical to use. IBS is a digestive disorder that affects an estimated 12% of Americans, according to the U.S. National Institutes of Health. It’s thought to be caused by problems in gut-brain communication … show that patients often have a “clear change” in their gut microbiome, according to Dr. Elena Ivanina, a gastroenterologist at Lenox Hill Hospital in New York City. The gut microbiome refers to the trillions of …

Mental Health

COVID-19 Created Stress & Dietary Habits | 4/1/2020

… The study of neurochemistry has revealed a wide variety of new signaling molecules that allow a series of communications from gut microbiome-brain pathways having direct effects on our brain. When combined with heightened levels … off-limits if our goal is to better manage our mental health. The foods we elect to eat can and do result in differences in our state of mental health when processed foods are compared …

Population Health

Drug used for liver disease also affects C. diff life cycle, reduces inflammation in mice | 3/30/2020

gut microbiome and can lead to relapse, or to fecal transplants that may have unknown side effects,” says Casey Theriot, assistant professor of population health and pathobiology at NC State and corresponding author of the work. Theriot and a team of researchers from NC State, Pennsylvania State University and the University of North Carolina at Chapel Hill looked at UDCA treatment of C. diff in vitro and as a pre …

Digital Health

Biotech innovations to spur next phase of personalized care | Modern Healthcare | 3/28/2020

… it in 10 years time,” Bracken said. “There’s so much promise there.” One of the first therapies to leverage the gut microbiome is fecal microbiota transplantation, or stool transplants, to treat Clostridium difficile infections. While … to a 2019 report from the Stanford Medicine Center for Digital Health and early-stage digital health venture fund Rock Health. While most of those devices track more general exercise, sleep and heart rate, and …

NIH

Artificial microbiome heterogeneity spurs six practical action themes and examples to increase study power-driven reproducibility | Nature | 3/19/2020

… analysis for study power-based sample size estimations using preclinical mouse data to support translational clinical trials, as requested in NIH/similar grants or publications. Download PDF Introduction According to a U.S. National Science Foundation … in current literature To identify husbandry factors capable of influencing gut microbiome and study reproducibility, especially mice per cage (MxCg) and mice per group (MxGr), we reviewed 172 recent studies selected from PubMed searching ‘diet …

Precision Medicine

Pendulum Therapeutics Announces Formation of Scientific and Medical Advisory Boards | Globe Newswire | 1/21/2020

… from analyzing and deciphering the complex world of the microbiome through rigorous excellent DNA science,” said Eric Schadt, dean for Precision Medicine at the Icahn School of Medicine at Mount Sinai, and founder and CEO … Mouse Core Facility, where he studies the impact of the gut microbiome on nutrition and drug metabolism. Marion Leclerc , PhD, of the French National Institute for Agricultural Research, is an expert in microbial ecology and …

Integrative Medicine

Probiotics: Don’t Buy the Online Hype - WebMD | 1/15/2020

… doctors, the benefits they can expect from probiotics,” Goldman said. Dr. Melinda Ring, executive director of the Osher Center for Integrative Medicine at Northwestern University in Chicago, said she wasn’t surprised by the findings. “This … in maintaining the body’s natural balance of beneficial bacteria – the gut microbiome . “We know the human microbiome is incredibly important to our health and the development of disease, but we’re just in the infancy of …

Genomics

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas | Nature | 1/13/2020

… gut microbiome). Cohort acknowledgements, ERF: we are grateful to all study participants and their relatives, general practitioners and neurologists for their contributions and to P. Veraart for her help in genealogy, J. Vergeer for supervision of the laboratory work and P. Snijders for his help in data collection. ERF was supported by the Consortium for Systems Biology (NCSB), both within the framework of the Netherlands Genomics Initiative (NGI)/NWO). The …

Department of Health and Human Services

Danone North America Announces 2019-2020 Gut Microbiome, Yogurt and Probiotics Fellowship Grant | PR Newswire | 12/16/2019

… in a row. As the name indicates, the grant is designed for graduate students to study the role of the gut microbiome, yogurt and probiotics for human health. Scientists in the field have found that … of Common Fund’s Human Microbiome Project (HMP) by the U.S. Department of Health and Human Services in 2007. While there is a better understanding of what a “normal” human microbiome looks like, how its controlled …

American College of Rheumatology

Unmet need in rheumatology: reports from the Targeted Therapies meeting 2019 | BMJ | 12/16/2019

… produced from this meeting. 1 However, with the expanse of targeted therapies and the recent clinical recommendations published from both American College of Rheumatology and the European Union League Against Rheumatism, 2–4 a document … microbiome is paramount. While it is highly likely that the gut microbiome is contributing to the disease, we do not know which bacteria are most important, which portion of the bowel is most important, the …

Clinical Data

Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection | Nature | 12/4/2019

… these dysbiotic states with pathogenic bacteria can lead to infectious complications beyond C. difficile infection. Taur et al. investigated the gut microbiome profiles of 94 bone marrow transplant recipients and reported that elevated gut Enterococcus … Data availability All sequencing data as well as the deidentified clinical data that support the findings of this study have been uploaded to the database of Genotypes and Phenotypes (dbGaP) with accession number phs001879.v1 …

Institutional Review Board

Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection | Nature | 12/4/2019

… these dysbiotic states with pathogenic bacteria can lead to infectious complications beyond C. difficile infection. Taur et al. investigated the gut microbiome profiles of 94 bone marrow transplant recipients and reported that elevated gut Enterococcus … recipients provided at least 1 fecal specimen. The Weill Cornell Institutional Review Board approved this study and each subject gave written informed consent. No organs were procured from prisoners and all kidney transplant recipients were …

Brain Health

Can You Eat to Beat Depression? | WebMD | 12/2/2019

… research, scientists aren’t sure how your diet affects your mental health. But they’re zeroing in on one promising area: your gut microbiome . “Of the more than 20 studies we are currently running at the Food … treat depression and may be important for other aspects of brain health, such as dementia . This is true for people across the lifespan – even very young children.” And if you do decide to adjust your …

Viome

Viome launches world’s-first, made to order, precision supplements based on deep health insights | Globe Newswire | 9/8/2020

Viome launches world’s-first, made to order, precision supplements based on deep health insights Viome Precision Supplements Sachet Example of Viome Precision Supplements sachet Viome Precision Supplements 1 Family Shot of Viome Precision Supplements BELLEVUE … Viome Health Intelligence ™ at home tests, which precisely measure individuals’ gut microbiome health, cellular health and mitochondrial health, with more than 30 specific health scores. Viome designs a precise formula, based on the health insights …

Fitbit

How to boost your metabolism naturally: seven workout and diet tips from HIIT and better sleep to spicy food | MSN | 8/10/2020

… running shoes Best running watch Best running headphones © Provided by T3 Track changes in your weight and BMI using the Fitbit Aria Air. All data is fed back to the Fitbit App where you can … Probiotics can also help improve metabolism and maintain a healthy gut microbiome, essential for well-functioning digestion. In a research paper published in 2013, the researchers concluded that “Probiotics may restore the composition of the …

Apple Health

Will Apple Solve the Longevity Problem? | by Mehdi Yacoubi | Jul, 2020 | Medium | 7/21/2020

Mehdi Yacoubi Follow Jul 21 · 6 min read Apple may be on its way to make us immortal Photo by freddie marriage on Unsplash This article is inspired by the excellent podcast episode Cameron Porter … off than people imagine. Instead, Apple could work on the gut microbiome to help people find the optimal diet. By developing an embeddable destined for your gut microbiome, Apple could help solve the nutrition problem …

Novartis

Ex-GSK Shingrix chief Guillaume Pfefer lands at Flagship as its second CEO-partner | FierceBiotech | 7/17/2020

… Afeyan, as well as the hybrid CEO-Partner role. It’s a relatively new position—Flagship picked its first CEO-Partner, Novartis alum Fabrice Chouraqui, in May this year. RELATED: Ex-GSK immunology chief to lead … an adviser. RELATED: Kintai’s obesity drug that works via the gut microbiome moves closer to the clinic One of its leading programs targets the gut microbiome to treat obesity. In January this year, the company …

HealthDay

Can Probiotics Help Ease Depression? | WebMD | 7/9/2020

Can Probiotics Help Ease Depression? By Amy Norton HealthDay Reporter WEDNESDAY, July 8, Probiotic supplements might help ease depression symptoms in some people, a new research review suggests. Researchers found that across seven small clinical … vast array of bacteria and other microbes – known as the “gut microbiome.” And those organisms are believed to do more than just aid in digestion. Research suggests the microbes are involved in everything from immune …

Vedanta Biosciences

Vedanta Biosciences Announces Positive Topline Data from Two Phase 1 Studies of VE202, a Rationally Defined Bacterial Consortium Being Advanced for Inflammatory Bowel Diseases (IBD) | Business Wire | 6/9/2020

CAMBRIDGE, Mass.–( BUSINESS WIRE )– Vedanta Biosciences , a clinical-stage company developing a new category of therapies for immune-mediated diseases based on rationally-defined consortia of human microbiome-derived bacteria, today announced positive topline data … intended effect of robustly and durably colonizing and changing the gut microbiome composition in a targeted manner,” said Bernat Olle, Ph.D., chief executive officer of Vedanta Biosciences. “Current treatments for IBD block mediators of inflammation …

Rebiotix

Rebiotix and Ferring Announce World’s First With Positive Preliminary Pivotal Phase 3 Data for Investigational Microbiome-based Therapy RBX2660 | Business & Finance | heraldchronicle.com | Business Wire | 5/6/2020

… more than ever, the world needs trustworthy reporting—but good journalism isn’t free. Please support us by subscribing. Subscribe AP Rebiotix and Ferring Announce World’s First With Positive Preliminary Pivotal Phase 3 Data for Investigational … 4,5 As a live biotherapeutic, aiming to help restore the gut microbiome community, RBX2660 may bring an innovative therapeutic option to patients suffering from this potentially deadly infection. “C. diff infection is a significant public …

Johnson & Johnson

Evolve BioSystems, Inc. Announces Collaboration with Janssen to Study the Impact of B. infantis EVC001 in the Reduction of Atopic Dermatitis | PR Newswire | 3/26/2020

DAVIS, Calif. , March 26, Evolve BioSystems, Inc., a global leader dedicated to improving human health through the gut microbiome, today announced a collaboration with Janssen Research & Development, LLC, one of the Janssen Pharmaceutical Companies of Johnson & Johnson, to conduct a clinical study in children at risk for developing atopic dermatitis. The study will assess the effects of introducing a specific gut bacterium, Bifidobacterium longum subspecies infantis (activated B. infantis EVC001 …

uBiome

Pharmacomicrobiomics in inflammatory arthritis: gut microbiome as modulator of therapeutic response | Nature | 3/10/2020

… and diagnostic methods relating to rheumatoid arthritis”). P.J.T. declares he is on the scientific advisory boards for Kaleido, Seres, SNIPRbiome, uBiome, and WholeBiome; there is no direct overlap between the current article and these consulting … Nayak, R.R., Ubeda, C. et al. Pharmacomicrobiomics in inflammatory arthritis: gut microbiome as modulator of therapeutic response. Nat Rev Rheumatol (2020). https://doi.org/10.1038/s41584-020-0395-3 …

Qiagen

Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection | Nature | 12/4/2019

… these dysbiotic states with pathogenic bacteria can lead to infectious complications beyond C. difficile infection. Taur et al. investigated the gut microbiome profiles of 94 bone marrow transplant recipients and reported that elevated gut Enterococcus … The DNA was further purified using QIAamp mini spin columns (Qiagen, Hilden, Germany). For each sample, duplicate 50 μL PCR reactions were performed, each containing 50 ng of purified DNA, 0.2 mM dNTPs, 1.5 mM …

Biogen

Monthly Research Review – November 2019 | 12/1/2019

… Alpha Synuclein Antisense A manuscript was posted on the OPEN ACCESS preprint database BioRxiv by the biotech firms ionis Pharma & Biogen and researchers from Michigan State University, which demonstrates antisense oligonucleotides targeting alpha synuclein mRNA … oh & the researchers observed cell-to-cell transmission! ). 6. PD Gut microbiome points towards bile acids Researchers conducted longitudinal metabolome analysis on 30 drug-naive, de novo Parkinson’s patients (& 30 matched controls) and revealed PD …

Arivale

How Old Are You? Your Body Might Disagree With That Answer | PRWeb | 11/23/2019

… may be improved.” The study sampled men and women who varied by age and health status and who participated in Arivale (now closed), which was a consumer data-intensive “scientific wellness” program. The wellness program … ISB findings, notably that the alpha diversity of an individual’s gut microbiome can be accurately predicted by examining metabolites in the blood, and that combining personal, dense, dynamic data (PD3) clouds with tailored behavioral coaching …

Thermo Fisher

Blueberry Attenuates Liver Fibrosis, Protects Intestinal Epithelial Barrier, and Maintains Gut Microbiota Homeostasis | 11/22/2019

… was monitored by ALT and AST activity, protein and mRNA were determined by western blot and RT-qPCR, and the gut microbiome was detected by Miseq. Results . The results showed that blueberry could reduce the … on an ABI 7900 Real-Time PCR system (Applied Biosystems; Thermo Fisher Scientific, Inc.). The following primer pairs were used for qPCR: claudin1: forward, 5′-GGACAACATCG TGACTGCTC-3′ and reverse, 5′-CCCAGCAGG ATGCCAATTAC-3′; claudin2 …

Thermo Fisher Scientific

Blueberry Attenuates Liver Fibrosis, Protects Intestinal Epithelial Barrier, and Maintains Gut Microbiota Homeostasis | 11/22/2019

… was monitored by ALT and AST activity, protein and mRNA were determined by western blot and RT-qPCR, and the gut microbiome was detected by Miseq. Results . The results showed that blueberry could reduce the … on an ABI 7900 Real-Time PCR system (Applied Biosystems; Thermo Fisher Scientific, Inc.). The following primer pairs were used for qPCR: claudin1: forward, 5′-GGACAACATCG TGACTGCTC-3′ and reverse, 5′-CCCAGCAGG ATGCCAATTAC-3′; claudin2 …

Pfizer

Inflammatory Bowel Disease Insight Report: Current Therapies, Drug Pipeline a… | 11/19/2019

… pharma and biotech companies. The market share is dominated by Janssen with 5 drugs in all phases (I-III) and Pfizer with 5 drugs in phase I and II. The remaining companies include Roche in … and S1P inhibitors), future treatments for IBD include modifying the gut microbiome, as well as identifying genomes involved in IBD to develop personalized treatments. Altering the microbiome has emerged as a more sustainable approach to …

Allergan

Inflammatory Bowel Disease Insight Report: Current Therapies, Drug Pipeline a… | 11/19/2019

… the first step in the treatment of inflammatory bowel disease. Anti-inflammatories include corticosteroids and aminosalicylates (5-ASA), such as Allergan ’s mesalamine ( Asacol HD , Delzicol , others), Salix Pharma ’s Colazal (balsalazide) and Uceris (budesonide … and S1P inhibitors), future treatments for IBD include modifying the gut microbiome, as well as identifying genomes involved in IBD to develop personalized treatments. Altering the microbiome has emerged as a more sustainable approach to …

National Medical Products Administration

Curiosity, Skepticism Over New Algae-Derived Alzheimer’s Drug | Medscape | 11/14/2019

National Medical Products Administration for mild-to-moderate AD. Oligomannate is a drug manufactured from an oligosaccharide extracted from marine algae and is the first novel drug approved for AD globally since 2003, the company said in a press release. It’s expected to be available in China by the end of the year. The drug works on the gut microbiome. It reportedly reconditions dysbiosis of gut microbiota, inhibits the abnormal …

Merck

A High Level of Circulating Valine Is a Biomarker for Type 2 Diabetes and Associated with the Hypoglycemic Effect of Sitagliptin | 11/11/2019

… randomized into two groups: one group was treated with sitagliptin (Sit; ), and the other group was treated with placebo ( ). Sit (Merck Sharp & Dohme, USA) was administered at a dose of 100 mg/d. Moreover, all … J. Turnbaugh, M. Hamady, T. Yatsunenko et al., “A core gut microbiome in obese and lean twins,” Nature , vol. 457, no. 7228, pp. 480–484, 2009. View at Publisher · View at Google Scholar · View at …

Quintiles

Shanghai Green Valley announces NMPA approval of oligomannate for Mild to Moderate Alzheimer’s Disease | 11/8/2019

… the diagnosis of mild to moderate Alzhemer’s disease completed the study. The trial was conducted in collaboration with IQVIA (formally Quintiles) and Signant Health (formerly Bracket) among other partners. Trial results demonstrated that Oligomannate statistically … preclinical data “supports the emerging idea that modulation of the gut microbiome via treatments such as GV-971 or other strategies should be further explored as novel strategies to slow the progression of AD”. Green …

IQVIA

Shanghai Green Valley announces NMPA approval of oligomannate for Mild to Moderate Alzheimer’s Disease | 11/8/2019

… patients with the diagnosis of mild to moderate Alzhemer’s disease completed the study. The trial was conducted in collaboration with IQVIA (formally Quintiles) and Signant Health (formerly Bracket) among other partners. Trial results demonstrated that … preclinical data “supports the emerging idea that modulation of the gut microbiome via treatments such as GV-971 or other strategies should be further explored as novel strategies to slow the progression of AD”. Green …

Wolters Kluwer

Gut microbiome is altered by burns, affected by fluid resuscitation | 10/28/2019

Major burns lead to changes in the gastrointestinal tract bacteria, and these alterations of the gut microbiome are influenced by resuscitation with intravenous (IV) fluids, according to animal studies reported in SHOCK: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches , the official journal of the Shock Society. The journal is published in the Lippincott portfolio by Wolters Kluwer. Potentially disease-causing gut bacteria are increased after a major burn, while …

WebMD

Many Common Meds Could Alter Your Microbiome - WebMD | 10/23/2019

The gut microbiome includes at least 1,000 species of bacteria and is influenced by a number of different factors, including medication. Research suggests that changes in the gut microbiome are associated with obesity , diabetes, liver diseases , cancer and neurodegenerative diseases. “We already know that the efficiency and the toxicity of certain drugs are influenced by the bacterial composition of the gastrointestinal tract and that the gut microbiota has been related …

AbbVie

New evidence of a link between Parkinson’s disease and the gut could inspire treatments | FierceBiotech | 6/26/2019

… gut microbiome to treat Parkinson’s and autism. New York-based Kallyope is also leveraging the gut-brain axis to find small molecules for metabolic and neurological diseases. Targeting alpha-synuclein is also a popular strategy in Parkinson’s research. AbbVie and Voyager Therapeutics recently expanded their partnership to use “vectorize” antibodies against the toxic protein clump. A team at Georgetown University found that Novartis’ blood cancer drug Tasigna might work for …

8VC

2019 closes the year with 251 digital health fundings | MobiHealthNews | 12/31/2019

… human and machine intelligence to take care of its members on a daily basis.” Q2 Series B $65 Redpoint Ventures, 8VC, Echo Health Ventures, StartUp Health, Sidewalk Labs, Thrive Capital, Maverick Ventures, Town Hall Ventures … DayTwo’s platform asks patients to send a sample of their gut microbiome to the company’s lab, where it is sequenced and characterized alongside blood test results and a user questionnaire. These results are delivered back …

Digital health investments bounced back in Q2 2019 with nearly $2.5B in funding | MobiHealthNews | 7/5/2019

… with human and machine intelligence to take care of its members on a daily basis.” Series B $65 Redpoint Ventures, 8VC, Echo Health Ventures, StartUp Health, Sidewalk Labs, Thrive Capital, Maverick Ventures, Town Hall Ventures … DayTwo’s platform asks patients to send a sample of their gut microbiome to the company’s lab, where it is sequenced and characterized alongside blood test results and a user questionnaire. These results are delivered back …

Mayo Clinic

Mayo scientists develop mathematical index to distinguish healthy microbiome from diseased | Mayo Clinic | 9/15/2020

gut microbiome — the trillions of microbes living inside the digestive system that regulate various bodily functions. To utilize the huge population of tiny organisms as a proxy for people’s well-being, Mayo Clinic researchers have developed a Gut Microbiome Health Index. This index distinguishes a healthy microbiome from one that is diseased. In a new study published in the Sept. 15 issue of Nature Communications, the researchers reveal how their …

Massachusetts General Hospital

Synthetic Biologics Reports 2020 Second Quarter Operational Highlights and Financial Results | PR Newswire | 8/6/2020

… Financial Results – Announced FDA Clearance of IND Application for SYN-020 Intestinal Alkaline Phosphatase (IAP) – – Signed Option License Agreement with Massachusetts General Hospital to Develop SYN-020 to Treat and Prevent Metabolic and Inflammatory Diseases … to reduce the impact of methane-producing organisms in the gut microbiome to treat an underlying cause of irritable bowel syndrome with constipation (IBS-C). The Company is also advancing SYN-020, an oral formulation …

Memorial Sloan Kettering

Memorial Sloan Kettering - Hackensack Meridian Health Partnership Announces Funding for Inaugural Immunology Research Collaboration Projects | PR Newswire | 6/5/2020

PRNewsfoto/Hackensack Meridian Health) (PRNewsfoto/John Theurer Cancer Center…) HACKENSACK, N.J. and NEW YORK As part of the Memorial Sloan Kettering – Hackensack Meridian Health Partnership, the two organizations have formed an Immunology Research Collaboration. Through … Sloan Kettering medical oncologist, is leading the project “Targeting the Gut Microbiome to Improve Outcomes after Allogeneic Hematopoietic Cell Transplantation.” This project will explore in an ongoing clinical trial whether certain antibiotics preserve specific anaerobic …

Meridian Health

Memorial Sloan Kettering - Hackensack Meridian Health Partnership Announces Funding for Inaugural Immunology Research Collaboration Projects | PR Newswire | 6/5/2020

PRNewsfoto/Hackensack Meridian Health) (PRNewsfoto/John Theurer Cancer Center…) HACKENSACK, N.J. and NEW YORK As part of the Memorial Sloan Kettering – Hackensack Meridian Health Partnership, the two organizations have formed an Immunology Research Collaboration. Through … Sloan Kettering medical oncologist, is leading the project “Targeting the Gut Microbiome to Improve Outcomes after Allogeneic Hematopoietic Cell Transplantation.” This project will explore in an ongoing clinical trial whether certain antibiotics preserve specific anaerobic …

Harvard Medical School

Synthetic Biologics Enters into Exclusive Option to License Intellectual Property for Use of SYN-020 to Treat and Prevent Age-Related Metabolic and Inflammatory Diseases | PR Newswire | 5/27/2020

… by Richard Hodin , MD, Chief of the Massachusetts General Hospital Division of General and Gastrointestinal Surgery and Professor of Surgery, Harvard Medical School , evaluated long-term oral supplementation of IAP, including SYN-020, in mice … the high therapeutic potential of IAP to promote GI and gut microbiome health,” said Steven A. Shallcross , Chief Executive and Financial Officer of Synthetic Biologics. “We are pleased to announce the expansion of our collaboration …

Northwestern Medicine

NORD Awards Eleven New Grants in Eight Disease States for Rare Disease Research | PR Newswire | 5/19/2020

… Ingo Helbig , MD, Children’s Hospital of Philadelphia ( Philadelphia, PA ); Beyond Negative Exome - Understanding the Genetics of FIRES Claude Steriade, MD and Deepak Saxena , MD, New York University School of Medicine ( New York, NY ); Gut Microbiome Alterations as a Mechanism of Immune Dysregulation in New Onset Refractory Status Epilepticus For the study of primary orthostatic tremor , with funding from public donations: Robert Chen, MA, MB BChir, MSc, Krembil Brain Institute, University …

Cedars-Sinai Medical Center

Synthetic Biologics Reports 2020 First Quarter Operational Highlights and Financial Results | PR Newswire | 5/5/2020

… sponsored clinical trial of SYN-010, intended to treat irritable bowel syndrome with constipation (IBS-C), being conducted out of Cedars-Sinai Medical Center (CSMC), as well as our planned Phase 1b /2a clinical trial … to reduce the impact of methane-producing organisms in the gut microbiome to treat an underlying cause of irritable bowel syndrome with constipation (IBS-C). The Company is also advancing SYN-020, an oral formulation …

University of Washington Medicine

Synthetic Biologics Reports 2020 First Quarter Operational Highlights and Financial Results | PR Newswire | 5/5/2020

… resistance (AMR) and acute graft-versus-host-disease (aGVHD) in allogeneic hematopoietic cell transplant (HCT) recipients, and (2) SYN-010, which is intended to reduce the impact of methane-producing organisms in the gut microbiome to treat an underlying cause of irritable bowel syndrome with constipation (IBS-C). The Company is also advancing SYN-020, an oral formulation of the enzyme intestinal alkaline phosphatase (IAP) to treat both local GI …

MD Anderson Cancer Center

AI finds microbial signatures in tumours and blood across cancer types | 3/11/2020

… blood across cancers. Nadim J. Ajami & Nadim J. Ajami is in the Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. Search for this author in: Google Scholar … microbes reside. This work has revealed a role for the gut microbiome in several types of cancer that arise in the intestinal lining itself 2 – 4 , and indicated that the gut microbiome might influence cancers …

Brigham and Women's Hospital

Trust Your Gut: How This Colombian Scientist Found Her Field | Forbes | 3/1/2020

… in microbiology – and she’s been focused on microbes ever since. Garcia-Bayona says when she joined the Comstock lab at Brigham and Women’s Hospital in Boston and Harvard Medical School they had a “very nice … Garcia-Bayon, Harvard Medical School/Brigham and Women’s Hospital “The gut microbiome plays a key role in human health and development, so it is one of the hottest research areas right now in the life …

Memorial Sloan Kettering Cancer Center

The Parker Institute for Cancer Immunotherapy Awards $2.75 Million to Support Six Early Career Researchers from Leading Research Institutions | PR Newswire | 2/26/2020

… of immunotherapy experts. PICI selected the early career researchers from leading research institutions in its network, including City of Hope, Memorial Sloan Kettering Cancer Center, the Perelman School of Medicine at the University of Pennsylvania … tumors that are resistant to current immunotherapies, particularly with the gut microbiome. She will explore new immunotherapy combinations with CAR T-cell therapies to overcome resistance in current treatments for patients with brain cancer. Kelly …

Johns Hopkins University School of Medicine

Treating multiple sclerosis with the help of the gut microbiome | FierceBiotech | 12/2/2019

… gut microbiome has been credited with producing an anti-inflammatory response in MS. Earlier this year, researchers from the University of California, San Francisco and the University of Toronto demonstrated that microbes in the gut activate plasma cells, which in turn produce anti-inflammatory antibodies in the central nervous system. Targeting the gut microbiome could prove useful in treating other brain diseases, like Parkinson’s. A team at the Johns Hopkins …

Providence St. Joseph Health

How Old Are You? Your Body Might Disagree With That Answer | PRWeb | 11/23/2019

… consent from program participants. This study builds on other important ISB findings, notably that the alpha diversity of an individual’s gut microbiome can be accurately predicted by examining metabolites in the blood, and that combining … in real-world clinical impacts. ISB is an affiliate of Providence St. Joseph Health, one of the largest not-for-profit health care systems in the United States. Share article on social media or email …

NYU Langone Health

Advances in Gut Microbiota of Viral Hepatitis Cirrhosis | 11/22/2019

… Institute of Infectious Disease, Peking University Ditan Teaching Hospital, Beijing, China 2 Division of Gastroenterology and Hepatology, Department of Medicine, NYU Langone Health, New York University School of Medicine, New York, NY, USA 3 Department … caused by long-term liver injury [ 1 ]. Recently, research about gut microbiome has emerged in liver disease fields. Samples are often derived from saliva, mucous, feces, and lavage fluids. A variety of study methods has …

UW Medicine

Functional Neurology: The Brain and the Gut Microbiome Connection | El Paso’s Injury Doctors® 915-850-0900 | 11/21/2019

… microbiome, help digest food, process nutrients, and produce immune molecules which helps heal injuries and fight inflammation. Surprisingly, however, the gut microbiome plays a much more fundamental role in the brain. Although the brain and … field is in its infancy,” stated Dr. William Depaolo, a UW Medicine gastroenterologist and director of the UW Center for Microbiome Sciences & Therapeutics. “I think about the gut microbiome like a biologist thinks about the …

Cleveland Clinic

NIH awards Cleveland Clinic $12 M to study link between gut microbes, heart disease | 11/19/2019

… Ph.D., Mark Brown, Ph.D., and their teams will continue to study the role of microbial pathways and cardiometabolic diseases Credit: Cleveland Clinic CLEVELAND: The National Institutes of Health has awarded more than $12 million to … first Program Project grants funded by NIH focused on the gut microbiome, a rapidly growing field that shows numerous links to human health and disease. The award is from the National Heart, Lung and Blood …

Michigan Medicine

E. coli gain edge by changing their diets in inflammatory bowel disease | Phys Org | 11/5/2019

… gut microbiome , composed of the trillions of bacteria that make their home inside the intestines, are key players. In a new paper in Nature Microbiology , Michigan Medicine researchers describe how bad bacteria gain a foothold over good bacteria in IBD and how something as simple as a diet change might reverse it. “The same bacteria are present in healthy and inflamed digestive tracts,” says Nobuhiko Kamada, Ph.D., of the division …

Baylor College of Medicine

Could More Coffee Bring a Healthier Microbiome? | WebMD | 10/28/2019

New research that links caffeine consumption to a healthy gut microbiome – the trillions of microorganisms that live in your digestive tract and affect your overall health– may prompt you to pour generously. In recent years … Dr. Li Jiao, an associate professor of medicine-gastroenterology at Baylor College of Medicine in Houston. But her advice for now? “If you love coffee, enjoy it. Follow your gut.” The new findings were to …

Richmond University Medical Center

He got a DWI even though he wasn’t drinking. Researchers found his body was producing alcohol - CNN | 10/25/2019

… swearing up and down that he hadn’t had anything to drink, doctors didn’t believe him either. But researchers at the Richmond University Medical Center in New York eventually discovered that the man was telling the … they believed the antibiotics he took years ago altered his gut microbiome and allowed fungi to grow in his gastrointestinal tract. The researchers then used antifungal therapies and probiotics to help normalize the bacteria in …

Beth Israel Deaconess Medical Center

Metabolism And Gut Bacteria: What You Need To Know | 10/4/2019

… gut microbiome was for the first time studied comprehensively by researchers at Beth Israel Deaconess Medical Center (BIDMC). The human gut microbiome is a collective term used to refer to 1,000 odd bacteria inhabiting the gut, belonging to 160 bacteria species. This surprisingly has more of an impact on metabolism and obesity than one would imagine. Why is this? Diversity in the gut bacteria becomes compromised with a high intake …

Mark Smith

Finch nets $90M to push C. diff microbiome med toward FDA filing, move into hep B, autism | FierceBiotech | 9/17/2020

… for infections that didn’t need them in 2018. And taking antibiotics is “like carpet bombing your microbiome,” Finch Therapeutics CEO Mark Smith, Ph.D., said. “We don’t yet understand what the long-term consequences of these … diff. is a pesky infection found in patients whose natural gut microbiome is wiped out with antibiotics, causing diarrhea and colitis, or colon inflammation. Of those patients infected with C. diff., 1 in 6 will …

Steven A. Shallcross

Synthetic Biologics Reports 2020 Second Quarter Operational Highlights and Financial Results | PR Newswire | 8/6/2020

… programs while continuing to navigate the unprecedented global health and economic crisis sparked by the COVID-19 global pandemic,” said Steven A. Shallcross , Chief Executive and Financial Officer of Synthetic Biologics. “We made significant progress … to reduce the impact of methane-producing organisms in the gut microbiome to treat an underlying cause of irritable bowel syndrome with constipation (IBS-C). The Company is also advancing SYN-020, an oral formulation …

Melinda Gates

Evolve BioSystems, Inc. announces Dr. Minhthy Nguyen as Senior Vice President of Research & Development, further advancing its position as the leader in infant gut health | PR Newswire | 7/28/2020

… gut microbiome. Evolve is a portfolio company of the Bill & Melinda Gates Foundation and Horizons Ventures, the venture division of the Li Ka Shing Foundation. Evolve is a spin-off from the Foods for Health Institute (FFHI) at the University of California, Davis and builds on more than a decade of research into understanding the unique partnership of the infant gut microbiome and breast milk components. SOURCE Evolve BioSystems …

Colleen Cutcliffe

Pendulum Therapeutics Launches First Medical Probiotic For People With Type 2 Diabetes | PR Newswire | 6/4/2020

gut microbiome with Pendulum Glucose Control,” said Colleen Cutcliffe , Ph.D., CEO and co-founder of Pendulum Therapeutics. “Medical probiotics are a new category of probiotics that deliver clinical efficacy for the management of a specific disease or condition with targeted and novel probiotic strains. Our patented formulation contains a novel and unique blend of a prebiotic and strains of beneficial probiotic bacteria that can’t be found in any other probiotic …

Angus Liu

Insights into how Novo Nordisk’s Saxenda cuts food cravings may inspire new obesity drugs | FierceBiotech | 3/5/2020

Insights into how Novo Nordisk’s Saxenda cuts food cravings may inspire new obesity drugs by Angus Liu Mar 5, 2020 7:32am Studies in rats showed that Novo Nordisk’s GLP-1 obesity drug Saxenda interacts with … suppressing effects. RELATED: Kintai’s obesity drug that works via the gut microbiome moves closer to the clinic The liraglutide finding adds to a growing body of discoveries by UPenn scientists related to obesity. Another team …

Donald Trump

Science X Newsletter Wednesday, Jan 22 | 1/23/2020

… events Suppression of newly found protein could lead to future treatments to slow Alzheimer’s progression Persistent environmental contaminant changes the gut microbiome of mice Researchers test cells with silicon anodes, alumina coatings that protect cathodes … has to help’ on police access to encrypted phones President Donald Trump weighed in Wednesday on Apple’s dispute with the US government over giving law enforcement access to encrypted iPhones, saying the company “has to …

Alex Stevenson

Clinical Update - 4D Announce New Study of MRx0518 in Pancreatic Cancer | PR Newswire | 1/6/2020

… gut microbiome. Alex Stevenson , 4D’s Chief Scientific Officer, commented: “Pancreatic cancer carries a poor prognosis and remains an area of significant unmet need. Encouraged by promising early signals in our other clinical studies, we believe MRx0518 has the potential to offer new treatment options and dramatically improve outcomes for patients with pancreatic cancer. This third study demonstrates 4D’s ongoing commitment to oncology.” 4D recently announced clinical observations from its ongoing …

Michael Greger

Physician and New York Times Bestselling Author Dr. Michael Greger Officially Releases New Sustainable Weight Loss Book - HOW NOT TO DIET | PR Newswire | 12/10/2019

WASHINGTON , Dec. 10, Dr. Michael Greger , M.D., FACLM, the internationally-renowned nutrition expert, physician, founder of Nutritionfacts.org, and author of the bestselling book How Not to Die , has turned his attention to the latest research … the insulin index, and the impact of foods on the gut microbiome—showing how plant-based eating is crucial to overall health. How Not to Diet goes beyond food to identify twenty-one weight-loss …

Paul Allen

New class of Allen Distinguished Investigators will focus on cellular processes | Yahoo News | 11/6/2019

… new stem cell models that will improve our understanding of different human diseases,” she said. The late Microsoft co-founder Paul Allen gave the Allen Distinguished Investigator program its start in 2010 as a way … will use stem cells to model how interactions between the gut microbiome and the brain might influence neuron death in patients with Parkinson’s disease. Savas Tay and his colleagues at the University of Chicago are …

Jeffrey Cummings

Alzheimer’s experts greet China’s surprise approval of a drug for brain disease with hope and caution | Science | AAAS | 11/5/2019

… and drug developers with a new plant-based compound it claims improves cognitive function in Alzheimer’s patients by altering their gut microbiomes. In mouse studies published earlier this year, this approach reduced inflammation in the … anywhere in the world for Alzheimer’s disease since 2003,” says Jeffrey Cummings, an Alzheimer’s researcher at the University of Nevada in Las Vegas, who is advising the drug’s developer, Shanghai, China–based Green Valley Pharmaceutical …

Kevin Ho

BiomeSense Nabs $2M to Expand Daily Gut Microbiome Tracking Platform | HIT Consultant | 10/4/2019

BiomeSense raises $2M in seed funding to expand its biosensor and analytics platform for daily gut microbiome tracking. – The company is working on completing its prototype biosensor and data modeling platform in preparation for the … and SOSV . Enabling Continuous Microbiome Testing Founded in 2018 by Kevin Honaker and Dr. Jack Gilbert, BiomeSense is developing an at-home biosensor to produce continuous gut microbiome data and a cloud-based analytics platform …

Naveen Jain

Viome Named to the 2019 CB Insights Digital Health 150, List of Most Innovative Digital Health Startups | Globe Newswire | 10/3/2019

… optional by understanding the root cause of chronic diseases and pinpointing methods of prevention, beginning with the analysis of the gut microbiome. Viome applies advanced sequencing technology developed at the Los Alamos National Lab to … as ‘incurable’ for so long,” said Viome CEO and Founder Naveen Jain. “Viome is on a mission to challenge traditional healthcare perceptions and practices, and this acknowledgment from CB Insights validates that we’re on the …

Anand Sanwal

Viome Named to the 2019 CB Insights Digital Health 150, List of Most Innovative Digital Health Startups | Globe Newswire | 10/3/2019

… optional by understanding the root cause of chronic diseases and pinpointing methods of prevention, beginning with the analysis of the gut microbiome. Viome applies advanced sequencing technology developed at the Los Alamos National Lab to … our ambitious goals in the years ahead.” CB Insights CEO Anand Sanwal revealed the final Digital Health 150 during Future of Health, a gathering of top executives across some of the largest healthcare institutions, startups …

Ken Blount

Microbiome Therapeutics Innovation Group Highlights Member Company Activity at IDWeek 2019 | PR Newswire | 10/1/2019

… IDWeek is one of the premier conferences each year that showcases the advancements and innovations aimed at helping patients,” said Ken Blount , Chief Scientific Officer of Rebiotix (a Ferring company) and MTIG Chair. “Many of … Recurrent Clostridioides difficile (C. Difficile) infection (rCDI), Stably Restores the Gut Microbiome after Vancomycin (Vanco)-Induced Dysbiosis in Adult Healthy Volunteers (HV) Time: 11:00 a.m. to 11:15 a.m. About The Microbiome Therapeutics Innovation Group The …

Eric Topol

Navigating ‘Nature’ With Editor-in-Chief Magdalena Skipper | Medscape | 9/20/2019

Eric J. Topol, MD: Hello. I’m Eric Topol, editor-in-chief of Medscape. If I ever was excited to have someone to interview, it would be Dr Magdalena Skipper, editor-in-chief of Nature . Welcome … time in science ever, with things like genome editing, the gut microbiome, and so much else. How do you try to capture things but not go too fast? How do you address concerns of replication …

Jessica Richman

Oops—Layoffs of lab staff at uBiome force the company to halt sample testing: reports | FierceBiotech | 7/11/2019

… report from Business Insider . The indefinite pause affects uBiome’s sole remaining offering—its direct-to-consumer Explorer test, which examines gut microbiome bacteria to provide information on wellness, food and lifestyle choices. uBiome previously halted … following FBI raid uBiome’s pair of founders and co-CEOs, Jessica Richman and Zac Apte, were placed on administrative leave in early May following the FBI’s search of its headquarters, where officers confiscated computers and …

Heiko Braak

New evidence of a link between Parkinson’s disease and the gut could inspire treatments | FierceBiotech | 6/26/2019

… travel from the gut to the brain. They published the findings in the journal Neuron. Back in 2003, German neuroanatomist Heiko Braak and colleagues found that in postmortem samples of Parkinson’s patients, clumps of alpha … netted $25 million to fund its programs that target the gut microbiome to treat Parkinson’s and autism. New York-based Kallyope is also leveraging the gut-brain axis to find small molecules for metabolic and …

State of California

Bacteria may be associated with risk of MS relapse | 10/7/2020

… California, Berkeley. Gut microbes digest food, produce vitamins (for example, B12 and K), create a barrier against pathogens, and regulate the immune system, among other tasks. Most current knowledge about the gut microbiome in MS comes from studies of patients with adult-onset MS. In 2016, Tremlett et al. found an increase in Desulfovibrionaceae and a decrease in Lachnospiraceae and Ruminococcaceae in patients with pediatric-onset MS. They also found …

New York, New York

Important: 5 Most Dangerous Side Effects of Low Carb Diet | 10/5/2020

… by the belief that eating fat, must cause us to get fat. Never mind that the real culprit —a disrupted gut microbiome from the growing refined foods and processed foods industry, sugar and high-fructose … were still growing. Enter: Dr. Atkins ’ New Diet Revolution, a New York Time’s bestseller in 1997—the perfect opportunity for another stab at the low carb, high fat diet propaganda. Atkins’ was followed by the …

State of New York

Important: 5 Most Dangerous Side Effects of Low Carb Diet | 10/5/2020

… by the belief that eating fat, must cause us to get fat. Never mind that the real culprit —a disrupted gut microbiome from the growing refined foods and processed foods industry, sugar and high-fructose … were still growing. Enter: Dr. Atkins ’ New Diet Revolution, a New York Time’s bestseller in 1997—the perfect opportunity for another stab at the low carb, high fat diet propaganda. Atkins’ was followed by the …

State of Washington

PERSISTENT METABOLOMIC ALTERATIONS CHARACTERIZE CHRONIC CRITICAL ILLNESS AFTER SEVERE TRAUMA - PubMed | National Institutes of Health | 10/6/2020

… Trauma Acute Care Surg Actions doi: 10.1097/TA. 2952. Online ahead of print. Authors 1 Department of Surgery, University of Washington, Seattle, WA. 2 Department of Anesthesiology and Pain Medicine, University of Washington, Seattle WA … including kynurenine, arachidonate, and glucuronic acid; and products of the gut microbiome including indole-3-propionate. Conclusions: The metabolic profiles in subjects who ultimately die or develop CCI differ from those who have recovered. In …

York, Pennsylvania

Important: 5 Most Dangerous Side Effects of Low Carb Diet | 10/5/2020

… by the belief that eating fat, must cause us to get fat. Never mind that the real culprit —a disrupted gut microbiome from the growing refined foods and processed foods industry, sugar and high-fructose … still growing. Enter: Dr. Atkins ’ New Diet Revolution, a New York Time’s bestseller in 1997—the perfect opportunity for another stab at the low carb, high fat diet propaganda. Atkins’ was followed by the Zone …

State of Massachusetts

Type 2 Diabetes Risk Linked to Prolonged Use of Common Acid Reflux Drugs | 9/29/2020

… Seventh Affiliated Hospital, Sun Yat-sen University, China, and colleagues in China, the Chinese University of Hong Kong, and at Massachusetts General Hospital in the U.S. “Screening for abnormal blood glucose and type 2 … level, PPIs may have an even more pronounced effect on gut microbiome than other commonly used drugs such as antibiotics, leading to warnings of overuse of PPIs and calls for further investigation into the sequelae …

San Diego, California

Penn State First to Investigate Effects of Exercise Training on Gut Microbiome in patients with NASH | 9/25/2020

San Diego and Juniata College, Dr. Jonathan Stine and his research team conducted the first study to investigate the effects of exercise training on gut microbiome in patients with NASH. The study analyzed stool samples from six subjects who were participating in the NASH Fitness Intervention in Thrombosis (NASHFit) Trial before and after 20-weeks of exercise training. Using 16S ribosomal RNA and metatranscriptomics analysis, the study demonstrated that exercise …

Cambridge, Massachusetts

Archaeologists unearth Medieval poop that might hint at what a healthy gut microbiome looks like | 10/10/2020

Archaeologists unearth Medieval poop that might hint at what a healthy gut microbiome looks like Friday, October 09, 2020 by: Virgilio Marin Bypass censorship by sharing this link: https://www.clearnewswire.com/463597.html ( Natural News ) Medieval … author Piers Mitchell, a biological anthropologist at the University of Cambridge . “If we are to determine what constitutes a healthy microbiome for modern people, we should start looking at the microbiomes of our ancestors,” he …

State of Illinois

Link between bad sleep, high blood pressure, and gut microbiome uncovered | 9/4/2020

A compelling new study, led by researchers from the University of Illinois at Chicago, has identified a complex relationship between disturbed sleep patterns, elevated blood pressure, and disruptions to the gut microbiome. The robust animal study suggests these three factors influence each other in a bidirectional fashion, and the findings could point to novel treatments mitigating the negative health effects of poor sleep. While there currently is a large volume …

San Francisco, California

Is there a vegetarian way to do the ketogenic diet? | MSN | 9/21/2020

… has more. Buzz60 Hear from nurse who shared shocking weight loss photos CNN’s John Berman speaks with Mike Schultz, the San Francisco nurse who shared before and after pictures of himself showing the impact that … But a traditional keto diet may be beneficial to the gut microbiome in some ways, according to a recent small study published the May 2020 issue of Cell . Researchers tracked microbial shifts related to the …

Chicago, Illinois

New faculty profile: Vanessa Leon focuses on microbiome and animal biologics research | 9/11/2020

… the University of Wisconsin-Madison. After I finished graduate school, I moved just a little south to the University of Chicago where I was a postdoc and then Instructor in the Department of Medicine, Section … time, due to advances in sequencing technologies, studies of the gut microbiome were reemerging, emphasizing its importance as a key physiological mediator. In that seminar series, I became fascinated with how this acquired microbial “organ …

State of Georgia

MiR-155-Mediated Deregulation of GPER1 Plays an Important Role in the Gender Differences Related to Inflammatory Bowel Disease | 9/16/2020

… role of GPER1 in the pathogenesis of IBD and its relationship with disease activity is not fully understood. Thus, the gut microbiome might be associated with the development of IBD. MicroRNA-155 is upregulated in … were homogenized with an appropriate amount of Trizol reagent (Omega, Georgia, USA) followed by the repeated addition to an adsorption column and were centrifuged. The total RNA was extracted from the tissue samples. Specific targeting …

Reading, Pennsylvania

FDA authorizes new IND to evaluate impact of multi-strain probiotic DS-01™ on gut microbiota of patients with IBS | PR Newswire | 9/29/2020

gut microbiome in patients with Irritable Bowel Syndrome (IBS), as well as the impact of DS-01 ™ on both intestinal cells and metabolic output of the native intestinal microbial communities. Continue Reading Figure 1. Representative photomicrograph shows the distribution of TLR4 proteins in the colonic mucosa of an IBS-Mixed patient alternating constipation with diarrhea [1]. Copyright © 2012 Belmonte et al. IBS is the most common gastrointestinal condition worldwide, with …

State of Alabama

Impact RTO Holdings partners with Digbi Health to provide the leading gut microbiome and genetics-based digital care program to their Rent a Center essential workers and families | Yahoo News | 9/10/2020

… first precision digital therapeutics platform focused on obesity and gut-related inflammatory comorbidities uses ethnic and gender-specific genomics and gut microbiome risk signals to provide personalized remote lifestyle and health support for at-risk … the states of Florida , Georgia , North Carolina , South Carolina , Tennessee , Alabama , Arkansas , and Mississippi . Impact RTO Holdings was looking for the next generation, proven, science-based digital wellness solution that can be delivered remotely to …

State of Ohio

Can Machine Learning Make Fecal Testing Part of CVD Screening? | MedPage Today | 9/10/2020

… Ohio. “While this demonstrates the promising potential of applying microbiome-based ML [machine learning] for predicting CVD, in the future, it will be of interest to further calibrate and improve predictive capability of ML modeling by including more samples from different sources or stratifying specific types of CVD incorporated with combinatorial features such as health records, in addition to gut microbiome data,” the authors said. Their study was presented as …

Birmingham, Alabama

Modification of fecal microbiota as a mediator of effective weight loss and metabolic benefits following bariatric… | National Institutes of Health | 8/26/2020

… Sciences, Faculty of Health & Life Sciences, Coventry University , Coventry, UK. 4 Aston Medical Research Institute, Aston Medical School, Aston University , Birmingham, UK. 5 NIHR CRF Human Metabolism Research Unit, University Hospitals Coventry and Warwickshire , Coventry … microbiome-brain axis. This includes the important role of the gut microbiome in the mediation of normal immunological development, inflammatory pathways, metabolic functioning, hypothalamic appetite regulation, and the absorption of essential nutrients as by-products …

State of Michigan

When Plants and Their Microbes Are Not in Sync, the Results Can Be Disastrous | 9/8/2020

As part of this study, my colleagues and I discovered that some genes and processes involved in controlling dysbiosis in plants may be similar to those in humans. September 8, 2020 By Sheng-Yang He , Michigan State University Many of us have heard about inflammatory bowel disease , a debilitating condition that is associated with an abnormal collection of microbes in the human gut – known as the gut microbiome. My lab …

State of Texas

8 foods that boost your immune system and can help keep you healthy | MSN | 9/30/2020

… benefits. This article was reviewed by Jason R. McKnight , MD, MS, a family medicine physician and clinical assistant professor at Texas A&M College of Medicine . Visit Insider’s Health Reference library for more advice. The … culture, which are bacteria that improve the health of your gut microbiome . A 2015 study published in the Annual Review of Immunology concluded that the health of the gut microbiome impacts immune function and contributes …

St. Louis, Missouri

How Microbiome Research Is Becoming a Huge Data Science | 8/28/2020

… vast amounts of data analysis. Michael White Expert Columnist Assistant professor of genetics at Washington University School of Medicine in St. Louis, Missouri, where he works on developing new biotechnologies. August 27, 2020 Michael White … bacteria that make up our “virtual organ,” known as the gut microbiome. Our microbiomes have a subtle but pervasive impact on the functioning of our metabolism, our susceptibility to disease, and our response to drugs …

Columbia, Missouri

Study finds gut microbiome plays important role in sleep regulation | 9/23/2020

Study finds gut microbiome plays important role in sleep regulation Transplanted bacteria from sleep-apnea mice caused sleep changes in recipient mice University of Missouri-Columbia IMAGE: David Gozal, MD, the Marie M. and Harry L. Smith Endowed Chair of Child Health at the MU School of Medicine view more Credit: None Obstructive sleep apnea (OSA) is a chronic sleep condition affecting more than one billion people worldwide. Evidence suggests …

Norwich, Connecticut

Faecal transplants could one day be used as a therapy to restore cognitive function in the elderly | 10/7/2020

… gut microbiome, which in turn impacted their spatial learning and memory. The research team hope that reversing the procedure could one day see faecal transplantation used to combat cognitive decline among the elderly. Dr David Vauzour, from UEA’s Norwich Medical School, said: “Ageing is an inevitable process that starts immediately after birth and ultimately leads to physical health problems as well as a decline in psychological well-being and cognitive …

State of Pennsylvania

Breath methane to hydrogen ratio as a surrogate marker of intestinal dysbiosis in head and neck cancer | 9/14/2020

… forced exhalation through the mouth (while pinching their nostrils closed) into a sealed three litre FlexFoil PLUS bag (SKC Ltd, Pennsylvania, USA) resulting in a mixed alveolar gas sample (mixture of alveolar air and respiratory … factors such as tobacco smoking have been previously described as gut microbiome modifiers 19 , and is also well-established as a risk factor for HNSCC. We analysed the effect of smoking on gastrointestinal gases exhaled …

State of Missouri

Study Finds Gut Microbiome Plays Important Role in Sleep Regulation | 10/6/2020

Study Finds Gut Microbiome Plays Important Role in Sleep Regulation Study Finds Gut Microbiome Plays Important Role in Sleep Regulation October 6, 2020 RTSleepWorld Research Transplanted bacteria from sleep-apnea mice caused sleep changes in recipient mice Evidence suggests OSA can alter the gut microbiome (GM) and may promote OSA-associated co-morbidities, including diabetes, hypertension, and cognitive problems. Researchers from the University of Missouri School of Medicine and MU …

Tracy, California

Probiotics: Expert insight on what this good bacteria can do for you | 6/17/2020

BPT) - A common misconception is that all bacteria are bad; however, there are thousands of different strains of bacteria, both good and bad, and many of the good bacteria can actually support health and wellness. The digestive system is an example of where “good bacteria” can make a difference. “Inside your digestive system live trillions of bacteria that make up your gut microbiome,” says Tracy Lockwood Beckerman, registered dietitian and …

Columbia, South Carolina

Study finds gut microbiome plays important role in sleep regulation | 9/23/2020

Study finds gut microbiome plays important role in sleep regulation Transplanted bacteria from sleep-apnea mice caused sleep changes in recipient mice University of Missouri-Columbia IMAGE: David Gozal, MD, the Marie M. and Harry L. Smith Endowed Chair of Child Health at the MU School of Medicine view more Credit: None Obstructive sleep apnea (OSA) is a chronic sleep condition affecting more than one billion people worldwide. Evidence suggests …