Gut Microbiome

Diet and Nutrition Have Profound Impact on Gut Microbiome | 3/26/2020

… from one or more portions of the digestive tract (that extends from the mouth to the anus). Bleeding can range from mild to severe and life threatening. READ MORE New Therapeutic Food Helps Repair Gut Microbiome of Malnourished Children New therapeutic food has been developed that repairs the gut microbiome in malnourished children and helps in healthy bone and brain development. It also improves immune and metabolic functions. READ MORE …

Researchers Call For Further Investigation Into Nutrition and Gut Microbiome | 3/26/2020

… at George Washington University and the National Institute of Standards and Technology, published in Nutrition Reviews, the team of researchers reaffirmed the need to further investigate the profound effects that nutrition has on the gut microbiome. The review’s authors consider the human microbiome to be an understudied target for novel strategies to diagnose or treat disease, given how much certain diseases may involve disruptions to the gut microbiome, and how …

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Prebiotics vs. Probiotics: What’s the Difference? | 3/25/2020

… Break down and digest food. Communicate with your immune system. Keep inflammation at bay. Can trendy probiotics and prebiotics keep gut health in tip-top shape? Gail Cresci, PhD, RD , an expert on the gut microbiome , offers her insights into the role pre- and probiotics may play in gut health. Gut bacteria: The BFFs you never knew you had “In human intestines, there are many strains of two main species …

Response to: ‘Can sexual dimorphism in rheumatoid arthritis be attributed to the different abundance of Gardnerella? by Liu et al | BMJ | 3/25/2020

… scale. RA, rheumatoid arthritis. Gardnerella has been detected not only in vaginitis but also in a variety of infections, such as hip arthritis and joint infections. 3 However, their biological and pathological roles in gut microbiome have been elusive. G. vaginalis was reported to have a symbiotic positive relationship with Prevotella bivia . 4 Considering the association of Prevotella with RA aetiology, 5–7 Liu et al proposed that G. vaginalis …

Diet, nutrition have profound effects on gut microbiome | 3/25/2020

… The article is published in Nutrition Reviews . Until recently, the human microbiome remained an understudied target for novel strategies to diagnose and treat disease. The prevalence of diseases that may involve disruption of the gut microbiome are increasing and there is currently no consensus in the scientific community on what defines a “healthy gut” microbiome. The review from GW and NIST systematically assessed the current understanding of the interactions between …

Diet, nutrition have profound impact on microbial composition in the gut | 3/25/2020

Dietary changes may prevent or reverse age-related effects in the brain Through their review, the authors found that the bi-directional relationship between nutrition and the gut microbiome is emerging as more research is conducted on how microbiota utilize and produce both macro and micronutrients. The authors found that research has mostly focused on the benefits of dietary fiber, which serves as fuel for gut microbiota, and also found …

From Poop To Personalized Medicine | 3/24/2020

… naked eye, billions of bacteria live in and on our bodies. In recent years, research has shown that these bacteria communities, or microbiomes, have an impact on human health and wellbeing. For example, the gut microbiome has been shown to regulate appetite, affect the level of inflammation in the intestinal tract and even play a role in diabetes and dementia. By characterizing the gut microbiome of individuals, scientists aim to …

Type 2 diabetes induced microbiome dysbiosis is associated with therapy resistance in pancreatic adenocarcinoma | 3/24/2020

… in MIA-PACA2 ( e ) and Su86.86 ( f ) cell lines Full size image T2D model showed microbial dysbiosis Since change in physiology is closely linked with microbial dysbiosis, we next analyzed the change in the gut microbiome during model development. Figure 1 a shows the events from each collection in the control and diabetes model. A comparison of gut microbiome between the control (C1) and streptozotocin (STZ) treated (D1) animals showed …

Prestigious Specialty Medical Event Is Canceled Due to Coronavirus Concerns: Dozens of the Nation’s Top Doctors on Healing Disease Through the Gut’s Microbiome Were Set to Meet for the Malibu Microbiome Meeting on March 28-29, 2020 in Malibu, California | PR Newswire | 3/24/2020

… Marketing for QOL Medical, LLC. The Malibu Microbiome Meeting is a continuing medical education (CME) event, which was scheduled for March 28-29, 2020 . In this two-day conference, groundbreaking research by the nation’s top gut microbiome physicians were to discuss the latest advancements in diseases like autism, cancer, Alzheimer’s, and Crohn’s disease. QOL Medical, LLC, a specialty pharmaceutical company focusing on treating gastrointestinal conditions, was set to sponsor a portion …

Antibiotics can limit body’s ability to uptake analgesics | 3/24/2020

LLNL biologists have found manipulating the gut microbiome with antibiotics alters the uptake and effectiveness of acetaminophen. The effectiveness of drug treatments can vary widely between individuals, which can lead to decreased efficacy or increased adverse reactions. Much of the variation can be contributed to genetics, but environmental factors such as nutritional status , disease state and gut bacterial composition also can influence the metabolic characteristics. In recent years, the contribution …

Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring | Nature | 3/24/2020

… been proposed that losses of specific bacterial species from our ancestral microbiota may be relevant to the increase in immune related diseases 2 ; and that depletion in the compositional and functional diversity of the gut microbiome may be in part linked to a decrease in dietary fiber intake 3 , 4 . The maternal gut microbiome during pregnancy plays an important role in stimulating fetal immune development 5 , 6 , 7 , 8 ; and …

US nativity and dietary acculturation impact the gut microbiome in a diverse US population | Nature | 3/24/2020

… community taxonomic diversity data. PLoS Comput Biol. 2017;13:e1005404. Google Scholar 24. David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505:559–63. Google Scholar 25. Falony G, Joossens M, Vieira-Silva S, Wang J, Darzi Y, Faust K, et al. Population-level analysis of gut microbiome variation. Science. 2016;352:560–4. Google …

Gut Microbiome Analysis in Morphine Exposure and Naltrexone-Induced Withdrawal | 3/24/2020

2019-2020 Abstract Introduction and Objectives: Relatively little is understood about the underlying physiological changes that occur in the withdrawal state of opiate users. Research on the effects of alcohol withdrawal on the Gut-brain axis (GBA) has revealed shifts in relative numbers of specific bacterial species that correlate with increased central nervous system (CNS) inflammation via neurological crosstalk. The purpose of this research was to determine if similar shifts in …

Birth by Caesarean section and otitis media in childhood: a retrospective cohort study | Nature | 3/23/2020

… with an increased risk of childhood conditions such as allergic disorders, diabetes, and obesity 1 , 2 . These associations are hypothesized to arise, in part, because birth by CS may promote adverse changes in the gut microbiome relative to vaginal birth. These changes may impair the normal functioning of the immune system and thereby contribute to the development of immune-related disorders 3 , 4 . Otitis media (OM) is a common infection …

Doctor’s Tip: Our body’s 5 defense mechanisms, immunity part 2 | 3/23/2020

This is column number two about the first of Dr. Li’s five body defense mechanisms — the immune system — taken from his book “Eat to Beat Disease, The New Science of How Your Body Can Heal Itself.” The other four defense systems are angiogenesis, regeneration (stem cells), the gut microbiome and DNA repair. Last week’s column discussed how the immune system helps fight off infections and cancer, and what we can …

324: Increasing Immunity Naturally & Skincare From the Inside Out With Four Sigmatic | 3/23/2020

… we put harmful things on our skin, a lot of that does actually enter the bloodstream, it does enter our body, and also changes our skin microbiome and can impact even through that our gut microbiome and all kinds of things down the road. So let’s talk about some of the common things people need to know and avoid when it comes to traditional skincare products. Tero: Yeah, just to …

Effects of underfeeding and oral vancomycin on gut microbiome and nutrient absorption in humans | Nature | 3/23/2020

Extended Data Fig. 2 Urine calorie content in response to dietary and pharmaceutical interventions. a , mean percent calorie loss in urine during overfeeding (n=25) and underfeeding (n=25). The Δ indicate the difference between underfeeding and overfeeding. Participants who started the dietary phase with overfeeding are represented by red dots, while those who started with underfeeding are represented by white dots. b , mean percent calorie loss in urine between …

Should I test my gut microbes to improve my health? | 3/23/2020

Amy Loughman and Heidi Staudacher 10 hours ago Mind and Body Should I test my gut microbes to improve my health? The idea of your gut microbiome – the whole community of gut microbes and their products – influencing your health is gaining momentum. Kateryna Kon/Shutterstock People are paying hundreds of dollars to have their gut microbes analyzed, hoping the insights will allow them to adjust their diet and improve their …

Infliximab Helps Gut Microbiome in Children with Crohn’s, Study Finds | 3/23/2020

Click here to subscribe to the IBD News Today Newsletter! Treatment with infliximab helps normalize the gut microbiome, soothing Crohn’s disease in children and adolescents, a study suggests. Longer studies are needed to understand if these medicines can fully restore the gut microbiome, the researchers noted, adding that stool exams may be a safer and more convenient alternative to endoscopy for monitoring treatment response in pediatric patients. The study, “Changes …

7 Ways A Gastroenterologist Supports His Microbiome & Overall Health | 3/23/2020

… the standard recommendations regarding social distancing and hygiene, it is important to remember that at least 70% of our immune system lies in the gut . It’s too early to know what happens in the gut microbiome during and after someone gets COVID-19. However, it is not too early to consider what we can do to help bolster our immune system since this is obviously part of the equation in …

Mental Health

Google Alert - related | 3/20/2020

Mental Health · Exercise · Food. Flag as irrelevant COVID-19 Related Closings, Cancellations and Delays Nebraska Medicine This is a list updated daily, of the latest COVID-19 related closings, cancellations and delays. Flag as irrelevant The Obesity- Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer … MDPI An incorrect food regimen from childhood is suggested to negatively impact the gut microbiome composition leading to obesity and …

uexpress | 3/20/2020

… gut microbiome. That’s the vast and complex community of bacteria, fungi, yeasts and viruses that live in our intestines. They number in the trillions, can account for 2 to 5 pounds of our weight and, as we’re learning every day, play complex and crucial roles in our physical and even mental health. In fact, because these microscopic creatures are necessary to survival, the gut microbiome is increasingly regarded as an …

Clinical Research

Nutritional approaches for treatment of Major Depressive Disorder | 3/18/2020

clinical research supporting the use of diet for treating depression. As we elucidate the mechanisms of inflammation, the gut microbiome, and their contribution to mental health, dietary manipulation is surely on its way. The anti-inflammatory diet, which recommends high fish intake, is commonly recommended to patients for a variety of health conditions due to its favorable omega-3 to omega-6 ratio. A healthy omega-3 to omega-6 …

What Contributes To Chronic Discomfort In Phoenix? | 3/14/2020

clinical research study shows that your body’s health and your psychological health are a lot more linked than initially impression. Some common instances of this are the link between the mind and also the gut microbiome. Chronic soreness might supply one more home window right here. Keep in mind that certain natural chemical we just spoke about. As things end up, it’s likewise produced extra for individuals that have long …

Population Health

Baylor College of Medicine and UH team up for new research collaborations | 3/11/2020

… of Medicine and the University of Houston have unique strengths and resources that can contribute to an outstanding platform for population health and precision medicine. Nine excellent projects were selected from a very large and … called “Dietary Plant-Based Exosome-Like Xanoparticles Impact the Human Gut Microbiome.” Malgorzata Borowiak, assistant professor of molecular and cellular biology and Emeritus McNair Scholar at Baylor, and Fatima A. Merchant, associate professor of engineering …

Baylor College of Medicine and UH announce collaborative grant awardees | 3/9/2020

… of Medicine and the University of Houston have unique strengths and resources that can contribute to an outstanding platform for population health and precision medicine,” said Dr. Ashok Balasubramanyam, vice president for academic integration at … called “Dietary Plant-Based Exosome-Like Xanoparticles Impact the Human Gut Microbiome.” Malgorzata Borowiak, assistant professor of molecular and cellular biology and Emeritus McNair Scholar at Baylor, and Fatima A. Merchant, associate professor of engineering …

Diabetes Management

European Biotech’s Top News in 2019 | 12/30/2019

… finding itself unable to keep up with its competitors, the French company Cellnovo decided to discontinue the manufacture of its diabetes management technology and go into administration. A gene therapy developed by the UK biotech … are based on giving people live bacterial strains from the gut microbiome of healthy donors. November The Belgian biotech Celyad revealed the first clinical efficacy data for an off-the-shelf CAR T-cell immunotherapy …

Digbi Health’s Gut Biome and DNA-Based Weight Loss and Diabetes Management Program Launches with Blue Shield of California | PR Newswire | 11/25/2019

Digbi Health’s Gut Biome and DNA-Based Weight Loss and Diabetes Management Program Launches with Blue Shield of California Access to Personalized, Proven, Digital Therapeutics for Obesity and Diabetes Redefines Precision Care and Disease Management … Blue Shield members access to a powerful, proven, DNA and gut microbiome-based precision care and personalized lifestyle medicine tool that is tailored to their unique biology and lifestyle. “Doctors and payers understand that obesity …

Digital Health

Gastroenterology in 2030: What the specialty will look like in 10 years | Becker’s ASC Review | 12/19/2019

… the mechanistic role of gut bacteria, and we can expect both diagnostics as well as data-driven therapeutics targeting the gut microbiome. Artificial intelligence. The rapid accumulation of clinical, imaging and multiomics data has lured … for GI services may lead to challenges in physician recruitment. ​ Digital health applications and nanotechnologies are progressing at a rapid speed and could enhance the way we treat and manage many GI diseases. The combination …

Nutrition Gets Personal | 12/4/2019

… nutrient levels in your blood or sweat. Other forms of data include an individual’s genetic makeup or the increasingly popular gut microbiome, which refers to the microbial community that resides in our gut. “There is … only on the service’s effectiveness. He cited Omada Health, a digital health company that employs this model. Employers and insurers using the digital service only pay for the percentage weight loss that users have seen …

Tufts University

We All Have Cancer (& How To Starve Cancer With The Foods You Eat). | 12/12/2019

… Science, Lancet, New England Journal of Medicine, and Nature Reviews. Dr. Li has held faculty appointments at Harvard Medical School, Tufts University, and Dartmouth Medical School. He serves on the board of directors of the … and immune-enhancing effects. Squid ink can even protect the gut microbiome against the side effects of cancer chemotherapy. – In my TED Talk , some of the biggest audience reactions came when I showed the results …

Physician and New York Times Bestselling Author Dr. Michael Greger Officially Releases New Sustainable Weight Loss Book - HOW NOT TO DIET | PR Newswire | 12/10/2019

… the ideal weight-loss diet—factors such as calorie density, the insulin index, and the impact of foods on the gut microbiome—showing how plant-based eating is crucial to overall health. How Not to … is a graduate of Cornell University School of Agriculture and Tufts University School of Medicine . All proceeds received from his books, DVDs, and speaking engagements are all donated to charity. NutritionFacts.org is a strictly non …

Food and Drug Administration

MaaT Pharma Announces the Presentation of Positive Data with Its Lead Microbiome Biotherapeutic in Intestinal-Predominant Acute Graft-versus-Host-Disease at the ASH 2019 Annual Meeting | Benzinga | 12/8/2019

… where there are no other available treatments after steroids and additional lines of treatment. These findings indicate that reestablishing the gut microbiome improved outcomes in these patients.” Moreover, MaaT Pharma is currently conducting the HERACLES … MaaT013 has been granted Orphan Drug Designation by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) and is already being administered in compassionate use. About MaaT Pharma MaaT Pharma, a …

MaaT Pharma Announces the Presentation of Positive Data with Its Lead Microbiome Biotherapeutic in Intestinal-Predominant Acute Graft-versus-Host-Disease at the ASH 2019 Annual Meeting | Business Wire | 12/8/2019

… where there are no other available treatments after steroids and additional lines of treatment. These findings indicate that reestablishing the gut microbiome improved outcomes in these patients.” Moreover, MaaT Pharma is currently conducting the HERACLES … MaaT013 has been granted Orphan Drug Designation by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) and is already being administered in compassionate use. About MaaT Pharma MaaT Pharma, a …

Human Microbiome

Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection | Nature | 12/4/2019

… these dysbiotic states with pathogenic bacteria can lead to infectious complications beyond C. difficile infection. Taur et al. investigated the gut microbiome profiles of 94 bone marrow transplant recipients and reported that elevated gut Enterococcus … Fisherbrand Commode Specimen Collection kit which was used in the Human Microbiome Project 29 and which, by design, minimizes cross-contamination of urine in fecal specimens 30 . We also highlight the significant difference in bacterial …

Potato power - Winnipeg Free Press | 12/2/2019

… any chronic inflammatory condition you can think of — from inflammatory bowel disease to diabetes — research has shown changes to the gut microbiome are associated with their development,” says registered dietitian Natasha Haskey, a PhD candidate … step among several toward an overarching goal of understanding the human microbiome and personalizing nutrition to promote better health. “Basically this speaks to the idea there is no one diet that fits everyone.” While it’s …

Brain Health

The calorie is out, and qualitative eating is in. Finally. | 12/4/2019

… gut microbiome, making 100 calories of sugar not at all equivalent to 100 calories of whole grains or cruciferous vegetables when it comes to your gut. Cording also predicts the discussion around food’s effects on our brain health to become more mainstream. “Choline might be the next hot thing,” she says, referring to a nutrient found in eggs and other foods that helps the brain regulate memory and mood . Again …

Can You Eat to Beat Depression? | WebMD | 12/2/2019

… research, scientists aren’t sure how your diet affects your mental health. But they’re zeroing in on one promising area: your gut microbiome . “Of the more than 20 studies we are currently running at the Food … treat depression and may be important for other aspects of brain health, such as dementia . This is true for people across the lifespan – even very young children.” And if you do decide to adjust your …

NIH

What Are Microbes? | 12/4/2019

… is a term often used to describe the microorganisms that make up specific areas within the body. For example, your gut microbiome would be different than the microbiome of your skin. Microbial cells are another … organs interaction with herbs, thanks to those trusty microbes. The NIH Human Microbiome Project Scientists are still studying the human microbiome today, which is mainly done through the Human Microbiome Project . This study has produced …

Cats communicate with the help of bacteria living in their butts | 12/2/2019

… gut microbiome, and they decided to pursue an unconventional route to fund their research, using Kickstarter to seek help from the general public. Ganz is one of the authors of a report on how crowdfunding research can fill in funding gaps when resources from organisations like the National Institutes of Health (NIH) are hard to come by. KittyBiome reached their funding goal , and involved their citizen scientist backers in the …

Viome

Want Better Gut Health? Start With an Advanced Gut Microbiome Test. | 2/27/2020

Want Better Gut Health? Start With an Advanced Gut Microbiome Test. Viome uses cutting edge science to map out every organism in your gut. / Microbiome Futurism fans: To create this content, a non-editorial team worked with an affiliate partner. We may collect a small commission on items purchased through this page. This post does not necessarily reflect the views or the endorsement of the Futurism.com editorial staff. Are you …

Viome’s CTO on why Gut Microbes plus AI can Reveal Perfect Diet | 2/19/2020

… who are battling a chronic disease — figuring out exactly how certain foods will affect your body is critical. That’s what Viome is trying to help people determine. The startup examines your microbiome to create personalized … understanding people’s biology on a molecular level, especially in their gut microbiome, using our proprietary metatranscriptomics technology combined with powerful AI-driven analysis to deliver them personalized insights and recommendations. What’s the difference between personalized …

HealthDay

Science X Newsletter Tuesday, Feb 4 | 2/5/2020

… advancing or spreading squamous cell carcinoma and as a target for new therapies. Costs of ART regimens increasing, outpacing inflation (HealthDay)—Initial regimens recommended for most people with HIV (PWH) are priced above $36,000 per … widely used pesticide atrazine leads to heritable changes in the gut microbiome of wasps, finds a study publishing February 4 in the journal Cell Host & Microbe. Additionally, the altered microbiome confers atrazine resistance, which is …

Curious about probiotics? Tread carefully | 2/2/2020

… she said. One area where probiotics may be helpful is in maintaining the body’s natural balance of beneficial bacteria—the gut microbiome. “We know the human microbiome is incredibly important to our health and the … Responsible Nutrition; Jan. 15, 2020, Frontiers in Medicine Copyright ©2020 HealthDay . All rights reserved …

National Medical Products Administration

China Approves Seaweed Sugar as New Alzheimer’s Drug | 1/12/2020

… Stroke March 2017 China Approves Seaweed Sugar as New Alzheimer’s Drug Shanghai Green Valley Pharmaceuticals (Green Valley) announced that China’s National Medical Products Administration (NMPA) has approved Oligomannate (GV-971) as new drug for the … preclinical data “supports the emerging idea that modulation of the gut microbiome via treatments such as GV-971 or other strategies should be further explored as novel strategies to slow the progression of AD”. Oligomannate …

Curiosity, Skepticism Over New Algae-Derived Alzheimer’s Drug | Medscape | 11/14/2019

National Medical Products Administration for mild-to-moderate AD. Oligomannate is a drug manufactured from an oligosaccharide extracted from marine algae and is the first novel drug approved for AD globally since 2003, the company said in a press release. It’s expected to be available in China by the end of the year. The drug works on the gut microbiome. It reportedly reconditions dysbiosis of gut microbiota, inhibits the abnormal …

Qiagen

Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection | Nature | 12/4/2019

… these dysbiotic states with pathogenic bacteria can lead to infectious complications beyond C. difficile infection. Taur et al. investigated the gut microbiome profiles of 94 bone marrow transplant recipients and reported that elevated gut Enterococcus … The DNA was further purified using QIAamp mini spin columns (Qiagen, Hilden, Germany). For each sample, duplicate 50 μL PCR reactions were performed, each containing 50 ng of purified DNA, 0.2 mM dNTPs, 1.5 mM …

The impact of storage conditions on human stool 16S rRNA microbiome composition and diversity | 12/2/2019

… time-to-freezing on gut microbiota profiles is therefore an important consideration for field studies in tropical LMIC, where the gut microbiome composition is less well established, temperature variation is more difficult to control, and … the weighing process. Samples were homogenised using a TissueLyser II (Qiagen, Hilden, Germany) at a speed setting of 25, and a 2 min centrifugation was used after addition of binding matrix. DNA concentration was quantified …

Arivale

Nutrition Gets Personal | 12/4/2019

… nutrient levels in your blood or sweat. Other forms of data include an individual’s genetic makeup or the increasingly popular gut microbiome, which refers to the microbial community that resides in our gut. “There is … for a service that could not provide a clear benefit. Arivale, a US start-up that sought to combine genetic testing with personal coaching to improve health, shows how important it is to have a …

How Old Are You? Your Body Might Disagree With That Answer | PRWeb | 11/23/2019

… may be improved.” The study sampled men and women who varied by age and health status and who participated in Arivale (now closed), which was a consumer data-intensive “scientific wellness” program. The wellness program … ISB findings, notably that the alpha diversity of an individual’s gut microbiome can be accurately predicted by examining metabolites in the blood, and that combining personal, dense, dynamic data (PD3) clouds with tailored behavioral coaching …

Thermo Fisher Scientific

The impact of storage conditions on human stool 16S rRNA microbiome composition and diversity | 12/2/2019

… time-to-freezing on gut microbiota profiles is therefore an important consideration for field studies in tropical LMIC, where the gut microbiome composition is less well established, temperature variation is more difficult to control, and … matrix. DNA concentration was quantified using a NanoDrop 1000 fluorimeter (Thermo Fisher Scientific, Waltham, MA, USA). 16S library preparation A modification of the Illumina 16S metagenomic sequencing library preparation protocol ( https://support.illumina.com/documents/documentation/chemistry …

Diagnostic Deals: The Fate of Illumina-PacBio Merger Hangs in the Balance | 11/30/2019

… patients with certain solid tumors, to run on Illumina’s NextSeq 550Dx system Lexent responsible for securing regulatory approvals + commercializing kit Thermo Fisher Scientific Owlstone Medical Objective: Discover + validate early cancer detection biomarkers by noninvasive breath … service in Australia that uses shotgun metagenomics to analyze customers’ gut microbiomes + generate a personalized report DISTRIBUTION, SALES & MARKETING AGREEMENTS …

Biogen

Monthly Research Review – November 2019 | 12/1/2019

… Alpha Synuclein Antisense A manuscript was posted on the OPEN ACCESS preprint database BioRxiv by the biotech firms ionis Pharma & Biogen and researchers from Michigan State University, which demonstrates antisense oligonucleotides targeting alpha synuclein mRNA … oh & the researchers observed cell-to-cell transmission! ). 6. PD Gut microbiome points towards bile acids Researchers conducted longitudinal metabolome analysis on 30 drug-naive, de novo Parkinson’s patients (& 30 matched controls) and revealed PD …

A Discontinued Alzheimer’s Trial Comes Alive Again. Will Biogen’s Aducanumab Survive the FDA Review? | 11/19/2019

A Discontinued Alzheimer’s Trial Comes Alive Again. Will Biogen’s Aducanumab Survive the FDA Review? Posted on: Subscribe If approved, aducanumab would be the first disease-modifying drug to treat Alzheimer’s disease, plus the first to … for their candidate, oligomannate. The drug works by balancing the gut microbiome, which in turn reduces amyloid beta deposition and leads to improved cognitive function. While the FDA rounds up their Peripheral and Central Nervous …

Thermo Fisher

Diagnostic Deals: The Fate of Illumina-PacBio Merger Hangs in the Balance | 11/30/2019

… patients with certain solid tumors, to run on Illumina’s NextSeq 550Dx system Lexent responsible for securing regulatory approvals + commercializing kit Thermo Fisher Scientific Owlstone Medical Objective: Discover + validate early cancer detection biomarkers by noninvasive breath … service in Australia that uses shotgun metagenomics to analyze customers’ gut microbiomes + generate a personalized report DISTRIBUTION, SALES & MARKETING AGREEMENTS …

Blueberry Attenuates Liver Fibrosis, Protects Intestinal Epithelial Barrier, and Maintains Gut Microbiota Homeostasis | 11/22/2019

… was monitored by ALT and AST activity, protein and mRNA were determined by western blot and RT-qPCR, and the gut microbiome was detected by Miseq. Results . The results showed that blueberry could reduce the … on an ABI 7900 Real-Time PCR system (Applied Biosystems; Thermo Fisher Scientific, Inc.). The following primer pairs were used for qPCR: claudin1: forward, 5′-GGACAACATCG TGACTGCTC-3′ and reverse, 5′-CCCAGCAGG ATGCCAATTAC-3′; claudin2 …

Novartis

Gut microbiome and CAR-T therapy | 11/19/2019

… malignancies (HM). Despite impressive outcomes in select patients, there remains significant heterogeneity in clinical response to CAR T-cells. The gut microbiome has emerged as one of the key host factors that could potentially be … cells directed against CD19 [CD19+ CAR T-cells; tisagenlecleucel (Kymriah™, Novartis)] in August 2017 to treat acute lymphoblastic leukemia (ALL) and then axicabtagene ciloleucel (Yescarta™, Kite Pharma) R/R large B-cell lymphoma in October …

Herd health: agriculture’s role in the global AMR crisis | 11/13/2019

… materials of the animal-focused pharmaceutical companies – many of which are divisions or spin-outs from mainstream pharma giants like Novartis, Merck and Pfizer – that sell medical products to farmers. Are drugmakers advertising their products … as prebiotics and probiotics to promote healthy bacteria in animals’ gut microbiomes. Even gene editing, a new frontier even in human health, is starting to emerge as a potential solution to some issues. In June …

Pfizer

Lung and Gut Microbiota as Potential Hidden Driver of Immunotherapy Efficacy in Lung Cancer | 11/11/2019

… PD-(L)1 and anti-Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) agents [ 15 , 16 ]. Several studies demonstrated that the gut microbiome regulates the power by which immunotherapy may stimulate the anticancer immune response (reviewed … received honoraria or speakers’ fee from MSD, Astra-Zeneca, Celgene, Pfizer, Helsinn, Eli-Lilly, BMS, Novartis, and Roche; E.B. also received research grants from I.A.S.L.C. (International Association for the Study of Lung Cancer), L.I.L.T. (Lega …

Seaweed-based Alzheimer’s drug just approved. It’s the first new one in 17 years | fox8.com | 11/6/2019

… Valley. “These results advance our understanding of the mechanisms that play a role in Alzheimer’s disease and imply that the gut microbiome is a valid target for the development of therapies,” neurologist Philip Scheltens, who … a large clinical trial for the drug. Johnson & Johnson, Merck, Pfizer and Eli Lilly have all previously abandoned projects to develop a drug for Alzheimer’s after unsatisfactory clinical data. 35.861660 104.195397 …

8VC

2019 closes the year with 251 digital health fundings | MobiHealthNews | 12/31/2019

… human and machine intelligence to take care of its members on a daily basis.” Q2 Series B $65 Redpoint Ventures, 8VC, Echo Health Ventures, StartUp Health, Sidewalk Labs, Thrive Capital, Maverick Ventures, Town Hall Ventures … DayTwo’s platform asks patients to send a sample of their gut microbiome to the company’s lab, where it is sequenced and characterized alongside blood test results and a user questionnaire. These results are delivered back …

Digital health investments bounced back in Q2 2019 with nearly $2.5B in funding | MobiHealthNews | 7/5/2019

… with human and machine intelligence to take care of its members on a daily basis.” Series B $65 Redpoint Ventures, 8VC, Echo Health Ventures, StartUp Health, Sidewalk Labs, Thrive Capital, Maverick Ventures, Town Hall Ventures … DayTwo’s platform asks patients to send a sample of their gut microbiome to the company’s lab, where it is sequenced and characterized alongside blood test results and a user questionnaire. These results are delivered back …

Johns Hopkins University School of Medicine

Treating multiple sclerosis with the help of the gut microbiome | FierceBiotech | 12/2/2019

… gut microbiome has been credited with producing an anti-inflammatory response in MS. Earlier this year, researchers from the University of California, San Francisco and the University of Toronto demonstrated that microbes in the gut activate plasma cells, which in turn produce anti-inflammatory antibodies in the central nervous system. Targeting the gut microbiome could prove useful in treating other brain diseases, like Parkinson’s. A team at the Johns Hopkins …

New evidence of a link between Parkinson’s disease and the gut could inspire treatments | FierceBiotech | 6/26/2019

Mounting evidence is pointing to an association between the gut and Parkinson’s disease. New research coming out of Johns Hopkins University School of Medicine has added some weight to the connection and offered a new … netted $25 million to fund its programs that target the gut microbiome to treat Parkinson’s and autism. New York-based Kallyope is also leveraging the gut-brain axis to find small molecules for metabolic and …

Mayo Clinic

Cardiovascular effects of prolonged exercise | 11/23/2019

… endurance exercise.” Missouri medicine 109.4 (2012): 312. O’Keefe, James H., et al. “Potential adverse cardiovascular effects from excessive endurance exercise.” Mayo Clinic Proceedings. Vol. 87. No. 6. Elsevier, 2012. You May Like! Cardiovascular effects of … College of Sports Medicine Conference – 2017 Impacts of Exercise, the Gut Microbiome/Metabolome and Immunity on the Brain Julia Basso – PhD… Day 3 of the American College of Sports Medicine Conference – 2017 Neurobiological Effects of …

Can Fecal Microbiota Transplant (FMT) Aid in Cancer Treatment? | PR Newswire | 11/21/2019

… Therapies On March 28-29 , 2020, Yinghong Wang , MD, PhD, MS from MD Anderson Cancer Center will present Implications of the Gut Microbiome in Cancer and Therapeutic Potential at the Malibu Microbiome Meeting (MMM) in Malibu … Allegretti ( Harvard ), James Adams ( Arizona ), Faming Zhang ( China ), Sahil Khanna (Mayo Clinic), Alex Khoruts ( Minnesota ), Yinghong Wang (MD Anderson), Mazen Noureddin (Cedars-Sinai), Scott Jackson (NIST), Howard Young (NIH), Sabine Hazan (Progenabiome), and Zain Kassam …

Providence St. Joseph Health

How Old Are You? Your Body Might Disagree With That Answer | PRWeb | 11/23/2019

… consent from program participants. This study builds on other important ISB findings, notably that the alpha diversity of an individual’s gut microbiome can be accurately predicted by examining metabolites in the blood, and that combining … in real-world clinical impacts. ISB is an affiliate of Providence St. Joseph Health, one of the largest not-for-profit health care systems in the United States. Share article on social media or email …

How Old Are You? Your Body Might Disagree With That Answer | Markets Insider | Business Insider | 11/23/2019

… consent from program participants. This study builds on other important ISB findings, notably that the alpha diversity of an individual’s gut microbiome can be accurately predicted by examining metabolites in the blood, and that combining … in real-world clinical impacts. ISB is an affiliate of Providence St. Joseph Health, one of the largest not-for-profit health care systems in the United States . SOURCE Institute for Systems Biology …

NYU Langone Health

Advances in Gut Microbiota of Viral Hepatitis Cirrhosis | 11/22/2019

… Institute of Infectious Disease, Peking University Ditan Teaching Hospital, Beijing, China 2 Division of Gastroenterology and Hepatology, Department of Medicine, NYU Langone Health, New York University School of Medicine, New York, NY, USA 3 Department … caused by long-term liver injury [ 1 ]. Recently, research about gut microbiome has emerged in liver disease fields. Samples are often derived from saliva, mucous, feces, and lavage fluids. A variety of study methods has …

Surprising Symptoms of Gut Problems | Livestrong.com | 10/24/2019

Your gut microbiome is a complex ecosystem made up of billions of microorganisms. When your good intestinal flora are flourishing, all is groovy with your gut (and your overall health). But when you have gut … into ethanol, says Lee Ann Chen, MD , a gastroenterologist at NYU Langone Health, who goes on to explain that “affected individuals become drunk despite not actually ingesting any alcohol.” The authors of the BMJ report …

Memorial Sloan Kettering Cancer Center

Rutgers Center for Lipid Research holds 2019 Symposium | 11/20/2019

… Harini Sampath (Rutgers) spoke about a novel role for intestine-derived lipids in regulating whole body energy balance and the gut microbiome. She was followed by Chumin Lo (Ohio University) discussed the function of apo … drew researchers from Drexel University, NYU, Brooklyn College, Columbia University, Memorial Sloan Kettering Cancer Center, SUNY Downstate Medical Center, NeuroLipid Research Foundation and local pharmaceutical companies. The RCLR is a center of the New Jersey …

Gut microbiome and CAR-T therapy | 11/19/2019

… malignancies (HM). Despite impressive outcomes in select patients, there remains significant heterogeneity in clinical response to CAR T-cells. The gut microbiome has emerged as one of the key host factors that could potentially be … collaborative, multicenter efforts. Studies are now being conducted at the Memorial Sloan Kettering Cancer Center and the Medical College of Wisconsin to analyze any potential association of gut microbiota diversity/composition and response to CAR …

Cleveland Clinic

AHA News: Quitting Smoking Could Lead to Major Changes in Gut Bacteria | 11/19/2019

… significant piece of science,” said the study’s lead author, Dr. Marcus Sublette. “It’s already been established that smoking changes the gut microbiome. What we’re adding here is that smoking cessation itself will continue to change … director of the Center for Microbiome & Human Health at the Cleveland Clinic, said the study results “hint at the need to take a global view of one’s metabolism, including the gut microbial community within.” Hazen …

NIH awards Cleveland Clinic $12 M to study link between gut microbes, heart disease | 11/19/2019

… Ph.D., Mark Brown, Ph.D., and their teams will continue to study the role of microbial pathways and cardiometabolic diseases Credit: Cleveland Clinic CLEVELAND: The National Institutes of Health has awarded more than $12 million to … first Program Project grants funded by NIH focused on the gut microbiome, a rapidly growing field that shows numerous links to human health and disease. The award is from the National Heart, Lung and Blood …

Massachusetts General Hospital

Latest Health Research | 11/19/2019

… correlation between sleep and overall good health Jonathan Kantrowitzat Health News Report - 3 weeks ago New study shows that your gut microbiome and quality sleep are interconnected As if you didn’t already have enough to … the condition, according to a new study from researchers at Massachusetts General Hospital (MGH). In a paper published in the journal Depression and Anxiety , the team reported that individuals who engaged in at least several …

Annihilating Alzheimer’s by How We Live | 11/16/2019

In 2017, researchers from Sweden’s Lund University found that the composition of the gut microbiome in mice can accelerate the development of Alzheimer’s, offering new avenues for preventing and possibly treating the disease. The composition … The Journal of Physiology, February 2016 Dr. Kathleen McKee with Massachusetts General Hospital in Boston led a study that looked at the effect high-speed cadence cycling had on Parkinson’s patients. While Dr. McKee and …

Cleveland Clinic, Cleveland OH

NIH awards Cleveland Clinic $12 M to study link between gut microbes, heart disease | 11/19/2019

… Ph.D., Mark Brown, Ph.D., and their teams will continue to study the role of microbial pathways and cardiometabolic diseases Credit: Cleveland Clinic CLEVELAND: The National Institutes of Health has awarded more than $12 million to … first Program Project grants funded by NIH focused on the gut microbiome, a rapidly growing field that shows numerous links to human health and disease. The award is from the National Heart, Lung and Blood …

Cleveland Clinic receives NIH grant to study link between gut microbes, cardiometabolic diseases | 11/19/2019

The National Institutes of Health has awarded more than $12 million to Cleveland Clinic researchers to study the critical link between gut microbial pathways and the development of cardiometabolic diseases. The team is led by … first Program Project grants funded by NIH focused on the gut microbiome, a rapidly growing field that shows numerous links to human health and disease. The award is from the National Heart, Lung and Blood …

Michigan Medicine

The Michigan Medicine blog recap | 11/8/2019

November 8, 2019 // FOUND IN: Michigan Medicine News A weekly roundup of articles from both the Michigan Health and Michigan Health Lab blogs, which cover stories on breaking news and research, health tips and wellness … Disease Michigan Medicine researchers discover how bad bacteria overtake the gut microbiome in Crohn’s disease. READ MORE Toilet Sign Series Parkinson’s Disease and Your Bladder Many diagnosed with Parkinson’s disease experience urinary tract issues. Here …

E. coli gain edge by changing their diets in inflammatory bowel disease | Phys Org | 11/5/2019

… gut microbiome , composed of the trillions of bacteria that make their home inside the intestines, are key players. In a new paper in Nature Microbiology , Michigan Medicine researchers describe how bad bacteria gain a foothold over good bacteria in IBD and how something as simple as a diet change might reverse it. “The same bacteria are present in healthy and inflamed digestive tracts,” says Nobuhiko Kamada, Ph.D., of the division …

Harvard Medical School

Wikileaks Document Reveals a “Secret US Base on the Moon” (VIDEO) | 11/3/2019

… of meat raises the risk of heart disease and cancer, when compared with a vegetarian diet.” Dr. Deepak Bhatt, a Harvard Medical School professor and Editor-in-Chief of the Harvard Heart Letter ( source ) A … a meat-containing meal, because they have a totally different gut microbiome. It takes only a few days for our gut bacterial patterns to change – the benefits of a plant-based diet start quickly!” – Michelle …

Fred Hutchinson

The Parker Institute for Cancer Immunotherapy Awards $2.75 Million to Support Six Early Career Researchers from Leading Research Institutions | PR Newswire | 2/26/2020

… at City of Hope, is developing new treatment approaches for tumors that are resistant to current immunotherapies, particularly with the gut microbiome. She will explore new immunotherapy combinations with CAR T-cell therapies to overcome … other institutions, including City of Hope, Dana-Farber Cancer Institute, Fred Hutchinson Cancer Research Center, Icahn School of Medicine at Mount Sinai, Institute for Systems Biology and Washington University School of Medicine in St. Louis …

George Church

Rejuvenation Roundup November 2019 | 12/2/2019

gut microbiome to increase production of butyrate and brain-derived neurotrophic factor (BDNF) in order to aid the brain and fight against age-related cognitive diseases. One Combination Gene Therapy Treats Multiple Age-Related Diseases : A team led by Dr. George Church has formulated a gene therapy that has successfully treated a mouse model of age-related diseases, including obesity and diabetes. We discussed this paper in this month’s Journal …

Harvard’s athlete-based next-generation probiotics technology licensed to FitBiomics | PR Newswire | 9/5/2019

… exclusive licensing agreement between Harvard’s Office of Technology Development (OTD) and FitBiomics. Wyss Institute researchers Jonathan Scheiman (shown here) and George Church developed the concept that the intestinal microbiome of elite athletes harbors higher number … harbor higher numbers of certain types of bacteria in their gut microbiomes (the commensal microbes populating the intestinal tract) that support or perhaps drive optimal levels of performance and recovery during and after challenging athletic …

Donald Trump

Science X Newsletter Thursday, Nov 14 | 11/15/2019

… England Journal of Medicine. Health groups urge president to ban all flavored e-cigarettes An ad campaign urging U.S. President Donald Trump to follow through on a commitment to ban all flavored electronic cigarettes, including … New process kills mosquito larvae using bacteria in the male’s gut microbiome A team of undergraduate student researchers at Ben-Gurion University of the Negev (BGU), who competed in the 2019 iGem competition, have developed …

11 November - Blogs I’m Following - 2 of 5 | 11/12/2019

… D.O., Ph.D. Story at-a-glance Recent data show that the fat-soluble hormone known as vitamin D modulates your gut microbiome, creating a healthier environment. This is likely one of the reasons sunlight has … ice age in 1979?? appeared first on Ice Age Now. Donald Trump Jr. Talk Marked By Anger Over No Q&A AP News at Snopes.com - 9 hours ago Members of the audience of about 450 …

Jeffrey Cummings

China Approves Seaweed Sugar as First New Alzheimer’s Drug in 17 Years | 11/8/2019

… 2020, in United States, Europe, China. A single Phase 3 study apparently found that GV-971, reported to alter the gut microbiome, slowed cognitive decline in people with AD. The trajectory of cognitive change in … is slightly larger than differences reported for cholinesterase inhibitors, said Jeffrey Cummings of the Cleveland Clinic, Lou Ruvo Center for Brain Health in Las Vegas, who is a scientific adviser to Green Valley. Separation between …

Shanghai Green Valley announces NMPA approval of oligomannate for Mild to Moderate Alzheimer’s Disease | 11/8/2019

… University in St. Louis and his colleagues wrote that the preclinical data “supports the emerging idea that modulation of the gut microbiome via treatments such as GV-971 or other strategies should be further explored … approved in many years and we applaud this innovation,” said Jeffrey Cummings, MD, Vice Chair for Research and Research Professor of UNLV Department of Brain Health and Professor and director of Center for Neurodegeneration and …

Jonathan Solomon

Is the microbiome about to change medicine for good? - ISRAEL21c | 10/15/2019

… results of the first phase of their groundbreaking Personalized Nutrition Project . The main takeaway message: Because of that very individualized gut microbiome, the same foods affect each person’s blood-sugar levels differently. Several large studies … and how phage therapy can get around that defense system. Jonathan Solomon, CEO of BiomX. Photo: courtesy BiomX is working on its first product, to treat acne, in collaboration with an international cosmetics company. The …

BiomX Licenses Novel Targets for Liver Disease Phage Therapy Program From JSR Corporation in Japan | PR Newswire | 6/11/2019

Jonathan Solomon , CEO of BiomX. “Our previous collaboration with JSR and Keio University School of Medicine yielded the lead target for our inflammatory bowel disease program. Phage therapy is an optimal treatment option in this case, allowing long term treatment specifically targeting the pathogenic driver in this chronic disease, without harming the beneficial gut microbiome. We look forward to rapidly advancing this program for the treatment of PSC, a disease …

Naveen Jain

Viome Named to the 2019 CB Insights Digital Health 150, List of Most Innovative Digital Health Startups | Globe Newswire | 10/3/2019

… optional by understanding the root cause of chronic diseases and pinpointing methods of prevention, beginning with the analysis of the gut microbiome. Viome applies advanced sequencing technology developed at the Los Alamos National Lab to … as ‘incurable’ for so long,” said Viome CEO and Founder Naveen Jain. “Viome is on a mission to challenge traditional healthcare perceptions and practices, and this acknowledgment from CB Insights validates that we’re on the …

Ken Blount

Microbiome Therapeutics Innovation Group Highlights Member Company Activity at IDWeek 2019 | PR Newswire | 10/1/2019

… IDWeek is one of the premier conferences each year that showcases the advancements and innovations aimed at helping patients,” said Ken Blount , Chief Scientific Officer of Rebiotix (a Ferring company) and MTIG Chair. “Many of … Recurrent Clostridioides difficile (C. Difficile) infection (rCDI), Stably Restores the Gut Microbiome after Vancomycin (Vanco)-Induced Dysbiosis in Adult Healthy Volunteers (HV) Time: 11:00 a.m. to 11:15 a.m. About The Microbiome Therapeutics Innovation Group The …

Siolta Therapeutics Joins Microbiome Therapeutics Innovation Group | Markets Insider | Business Insider | 7/17/2019

… for microbiome therapeutics and microbiome-based products. Siolta Therapeutics, a clinical-stage biotech company, researches specific microbes that promote healthy gut microbiome development in infants to prevent immune dysfunction in childhood. The company has built … therapeutics for the prevention and treatment of inflammatory diseases,” said Ken Blount , Ph.D., Chief Scientific Officer of Rebiotix, Inc. and Chairman of MTIG. “We are eager to have Siolta Therapeutics participate in our coalition to …

Jessica Richman

Oops—Layoffs of lab staff at uBiome force the company to halt sample testing: reports | FierceBiotech | 7/11/2019

… report from Business Insider . The indefinite pause affects uBiome’s sole remaining offering—its direct-to-consumer Explorer test, which examines gut microbiome bacteria to provide information on wellness, food and lifestyle choices. uBiome previously halted … following FBI raid uBiome’s pair of founders and co-CEOs, Jessica Richman and Zac Apte, were placed on administrative leave in early May following the FBI’s search of its headquarters, where officers confiscated computers and …

John Green

For Novelist John Green, OCD Is Like An ‘Invasive Weed’ Inside His Mind | NPR | 6/28/2019

… thought that you’re able to have.” Originally broadcast Oct. 19, 2017. Hear The Original Interview Shots - Health News For Novelist John Green, OCD Is Like An ‘Invasive Weed’ Inside His Mind DAVID BIANCULLI, HOST: This … average per kiss,” endquote. After 6-month follow-up, human gut microbiomes appear to be modestly but consistently altered. (Reading) His bacteria would be in me forever, 80 million of them breeding and growing and …

For Novelist John Green, OCD Is Like An ‘Invasive Weed’ Inside His Mind : NPR | 6/28/2019

… thought that you’re able to have.” Originally broadcast Oct. 19, 2017. Hear The Original Interview Shots - Health News For Novelist John Green, OCD Is Like An ‘Invasive Weed’ Inside His Mind DAVID BIANCULLI, HOST: This … average per kiss,” endquote. After 6-month follow-up, human gut microbiomes appear to be modestly but consistently altered. (Reading) His bacteria would be in me forever, 80 million of them breeding and growing and …