Gut Microbiome

Gut bacteria may predict risk of pulmonary hypertension | 2/25/2020

A team of researchers has found that the microflora of bacteria within the gut of humans could be a contributor to the development of pulmonary arterial hypertension (PAH). The study titled, “Altered Gut Microbiome Profile in Patients With Pulmonary Arterial Hypertension,” in the latest issue of the American Heart Association’s journal Hypertension . Normal flora of the small intestine, bacteria Lactobacillus, 3D illustration. Lactic acid bacteria. Image Credit: Kateryna Kon / Shutterstock …

AI Algorithms Used To Develop Drugs That Fight Drug-Resistant Bacteria | 2/25/2020

One of the biggest challenges facing the medical industry is drug-resistant bacteria. Currently, there are some estimated 700,000 deaths due to drug-resistant bacteria, and more strains of drug-resistant bacteria are developing. Scientists and engineers are attempting to develop new methods of combatting drug-resistant bacteria. One method of developing new antibiotics is employing artificial intelligence and machine learning to isolate new compounds that could deal with new …

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Mediterranean Diet Found To Increase Longevity By Improving Microbiome, Says Study | 2/25/2020

The Mediterranean diet, known for being one of the healthiest diets in the world, has scored bonus points after a recent study found that it also aids in brain function and longevity by improving the microbiome in the gut, reported CNN . The gut microbiome is important for many key processes in the body, including determining how well nutrients are absorbed, the functionality of the immune system, and energy and metabolism …

Accounts in Transit: Coyne Public Relations Picks Up Evolve Biosytems | 2/25/2020

Accounts in Transit: Coyne Public Relations Picks Up Evolve Biosytems Tue., Feb. 25, 2020 By Steve Barnes Coyne Public Relations picks up Evolve BioSystems , a company dedicated to researching solutions to establish, restore and maintain a healthy gut microbiome in babies. Coyne will work to develop a communications strategy aimed at raising awareness among healthcare professionals and new mothers of Evolve’s most recent product, Evivo. The company says is Evivo …

Is the Food You Eat Affecting Your Mood? | 2/25/2020

Here is a little background on your stomach: Each individual has a unique gut microbiome, which is a community of bacteria living in the lining of your digestive tract. It is important to have a balance of good and bad bacteria in the gut , when there are more bad bacteria, diseases can occur (Inflammatory bowel disease, asthma, diabetes, etc.) What you eat can affect the balance, so it is important …

What’s an Unhealthy Gut? How Gut Health Affects You | 2/24/2020

… and cancer. At one time, our digestive system was considered a relatively “simple” body system, comprised essentially of one long tube for our food to pass through, be absorbed, and then excreted. The term “ gut microbiome ” refers specifically to the microorganisms living in your intestines. A person has about 300 to 500 different species of bacteria in their digestive tract. While some microorganisms are harmful to our health, many are …

Is healthy ‘Mediterranean diet’ good for your microbiome? | Health24 | 2/24/2020

… either eating their usual diet or a Mediterranean diet that had been specially tailored to older people. Eating the Mediterranean diet for a year was tied with a number of beneficial changes to the gut microbiome . For example, the diet seemed to help stem the loss of diversity in bacterial species in the gut – a more diverse microbiome is thought to be healthier. The Mediterranean diet was also tied to …

Acid suppression linked with multidrug-resistant microorganism colonization | 2/24/2020

Acid-suppression medication may increase the odds for colonization by multidrug-resistant microorganisms, according to a meta-analysis published in JAMA Internal Medicine . Roel P.J. Willems, MD, of the department of medical microbiology and infection at Amsterdam UMC, and colleagues wrote that use of acid suppressors is on the rise, with proton pump inhibitor use alone doubling in the United States between 1999 and 2012. This has led to concerns …

Investigation Seeks Deeper Answers on Diet-Heart Disease Connections | 2/24/2020

Home » Investigation Seeks Deeper Answers on Diet-Heart Disease Connections Investigation Seeks Deeper Answers on Diet-Heart Disease Connections February 24, 2020 tmao By Jonathan Springston , Editor, Relias Media Eating a healthy diet is important, but what happens inside the gut microbiome specifically when one sticks to a plant-based diet? A group of investigators recently discovered that consuming more vegetables and fewer animal products may thwart a certain microbial …

Poor dental health linked to greater liver cancer risk: Oral and gut microbiomes are linked | 2/24/2020

… that participants with poor oral health were more likely to be younger, female, living in a deprived socioeconomic area and consumed less than two portions of fruit and vegetables every day. (Related: Oral health, gut microbiome and cancer prevention: Poor dental hygiene is associated with 75 percent INCREASED RISK of liver cancer ) Overall, the researchers noted that while there were no associations between self-reported poor oral health and gastrointestinal …

TPV Podcast Episode 392: Are Mushrooms Really Magic? Part 2 | 2/24/2020

… on iTunes ! The Paleo View (TPV), Episode 392: Are Mushrooms Really Magic? Part 2 Introduction (0:44) Stacy isn’t in charge this week! Time for Sarah to nerd out! Sarah is almost done with her gut microbiome book. She thinks only 2 months before she turns it in. Now that she has all this information on the microbiome, it’s now of equal importance as nutrient density. “One of the foods that …

Targeting the Gut Microbiome Might Work for PAH | Medpage Today | 2/24/2020

Changes in bacterial metabolites associated with a form of pulmonary hypertension MedpageToday by Nicole Lou, Staff Writer, MedPage Today February 24, 2020 A unique gut microbiome profile was implicated in pulmonary arterial hypertension (PAH), a proof-of-concept study showed. Whether someone had PAH was predicted with 83% accuracy using a statistical model that took into account the presence or absence of 30 bacterial species, according to Mohan Raizada, PhD …

Because the World Needs Superheroes, These Doctors Work to Advance Medical Research and Save Lives | 2/23/2020

… no third-party interests other than those of the patients whose lives they’re fighting to save. Though Hippocrates said all disease begins in the gut nearly 3000 years ago, few medical publications on the gut microbiome were written before the 21st century. As studies discover numerous connections between the microbiome and various diseases, over 60,000 related journals have been published in the last ten years. It is no longer a …

A New Class of Bacterial Enzymes is Discovered | 2/23/2020

WRITTEN BY: Carmen Leitch We have many things in common with one another, but there are also things about each of us that are unique, like our fingerprints, our genome, and our gut microbiome. We carry trillions of microbes in our digestive tracts, and those microorganisms have a powerful influence on our health. Researchers have also found that they not only help us digest food, they can also metabolize the …

How Your Microbiome May be Affected by a Ketogenic Diet | KetoDiet Blog | 2/23/2020

… your gut biome. In this article, I’d like to demonstrate that an amount of starchy carb-rich foods that would be prohibitive of nutritional ketosis is not necessary for a thriving ‘biome. Why is Gut Microbiome Important? Some people are convinced we know nothing about the ‘biome, and dietary fibre is useless. I’m not one of those people nor am I trying to convert anyone. There are plenty of examples …

A Mediterranean Diet May Alter the Gut Microbiome to Improve Longevity | 2/22/2020

A Mediterranean Diet May Alter the Gut Microbiome to Improve Longevity By Please enter your name here You have entered an incorrect email address! Please enter your email address here Categories Videos February 22, 2020 Orektiko is an appetizing taste into the finest Greek cuisine. We provide you with all sorts of mouth watering news, recipes and videos from the region. Contact us …

Microbes in our ancestors’ stomachs helped them adapt to new areas | 2/22/2020

Have gut bacteria, will travel. By Rob Banino 22nd February, 2020 at 08:00 There is a wide variety in the populations of bacteria found in the human gut microbiome around the world. Researchers believe the microbiome’s ability to adapt helped early humans to survive and spread around the globe by allowing them to digest the new foods they encountered as they travelled. Our ancestors could even have used these microbes …

ProDigest and CosmosID Launch the ‘Gut Microbiome Therapeutic Innovation’ Challenge | 2/22/2020

… accurately and rapidly identify & characterise microorganisms within a metagenomic sample. By generating high-quality, standardised NGS data at CosmosID’s CLIA & GLP facility, new insight can be gained from studies utilizing metagenomics.Researchers may enter the Gut Microbiome Therapeutic Innovation challenge by submitting a short abstract proposing a project that would make use of the ProDigest and CosmosID technologies. Abstract submission opens on February 5, 2020 and closes at 2359 PST on …

New class of enzymes could lead to bespoke diets, therapeutics — Long Room | 2/22/2020

Everyone seems to have an opinion about which foods to eat or avoid, how to lose weight (and keep it off!), and which superfood to horde. But there’s a better place to search for health secrets than in a tropical berry: the human gut. Each person’s gut microbiome—the trillions of bacteria living inside the human gastrointestinal tract—is different. And individual strains of bacteria interact with food, drugs, vitamins …

Shoreline Biome to Present Strain-Level rRNA Amplicon Research at AGBT 2020 | PRWeb | 2/21/2020

… L. Brichacek and Candice M. Brown, Ph.D. of West Virginia University School of Medicine’s Department of Neuroscience. Scientists do not yet fully understand the relationship between sepsis and dementia, but sepsis can change the gut microbiome in ways that affect health and behavior. Dr. Brown and her team conducted strain-level microbial profiling using Shoreline Biome’s StrainID kit and revealed that microbial communities change in response to sepsis. Microbiome profiling …

Mental Health

Science X Newsletter Thursday, Feb 13 | 2/14/2020

gut microbiome more human-like There is a growing consensus that the gut microbiome is involved in many aspects of physical and mental health, including the onset of Parkinson’s disease, multiple sclerosis, and even some behaviors. The microbiota of the small intestine in particular are likely to have important effects on human health because most nutrients and drugs are absorbed by the body in this location. To study the gut …

Google Alert - Health | 2/14/2020

gut microbiome more human-like Science Codex There is a growing consensus that the gut microbiome is involved in many aspects of physical and mental health, including the onset of Parkinson’s disease, multiple sclerosis, and even some behaviors. The microbiota of the small intestine in particular are … Flag as irrelevant Raleigh News & Observer Flu claims 9 more lives in North Carolina, including a young child Raleigh News & Observer Nine more …

Clinical Research

organic loose leaf herbal tea Options | 1/11/2020

… loss benefits. According to a research study from the European Journal of Nutrition, black tea is found to have a gut microbiome that decreases one’s weight by decreasing the gut microorganisms. These variables aid control … just one of the unique teas that is shown from clinical research for its capacity to eliminate bacteria and avoid infections from entering your body such as flu. Its capabilities raise anti-oxidants required in …

An Unbiased View of Organic teas | 1/11/2020

… loss advantages. According to a research study from the European Journal of Nutrition, black tea is found to have a gut microbiome that reduces one’s weight by decreasing the gut microorganisms. These variables aid control … just one of the unique teas that is shown from clinical research for its capacity to eliminate bacteria as well as protect against infections from entering your body such as flu. Its capacities raise antioxidants …

Diabetes Management

European Biotech’s Top News in 2019 | 12/30/2019

… finding itself unable to keep up with its competitors, the French company Cellnovo decided to discontinue the manufacture of its diabetes management technology and go into administration. A gene therapy developed by the UK biotech … are based on giving people live bacterial strains from the gut microbiome of healthy donors. November The Belgian biotech Celyad revealed the first clinical efficacy data for an off-the-shelf CAR T-cell immunotherapy …

Digbi Health’s Gut Biome and DNA-Based Weight Loss and Diabetes Management Program Launches with Blue Shield of California | PR Newswire | 11/25/2019

Digbi Health’s Gut Biome and DNA-Based Weight Loss and Diabetes Management Program Launches with Blue Shield of California Access to Personalized, Proven, Digital Therapeutics for Obesity and Diabetes Redefines Precision Care and Disease Management … Blue Shield members access to a powerful, proven, DNA and gut microbiome-based precision care and personalized lifestyle medicine tool that is tailored to their unique biology and lifestyle. “Doctors and payers understand that obesity …

Digital Health

Gastroenterology in 2030: What the specialty will look like in 10 years | Becker’s ASC Review | 12/19/2019

… the mechanistic role of gut bacteria, and we can expect both diagnostics as well as data-driven therapeutics targeting the gut microbiome. Artificial intelligence. The rapid accumulation of clinical, imaging and multiomics data has lured … for GI services may lead to challenges in physician recruitment. ​ Digital health applications and nanotechnologies are progressing at a rapid speed and could enhance the way we treat and manage many GI diseases. The combination …

Nutrition Gets Personal | 12/4/2019

… nutrient levels in your blood or sweat. Other forms of data include an individual’s genetic makeup or the increasingly popular gut microbiome, which refers to the microbial community that resides in our gut. “There is … only on the service’s effectiveness. He cited Omada Health, a digital health company that employs this model. Employers and insurers using the digital service only pay for the percentage weight loss that users have seen …

Tufts University

We All Have Cancer (& How To Starve Cancer With The Foods You Eat). | 12/12/2019

… Science, Lancet, New England Journal of Medicine, and Nature Reviews. Dr. Li has held faculty appointments at Harvard Medical School, Tufts University, and Dartmouth Medical School. He serves on the board of directors of the … and immune-enhancing effects. Squid ink can even protect the gut microbiome against the side effects of cancer chemotherapy. – In my TED Talk , some of the biggest audience reactions came when I showed the results …

Physician and New York Times Bestselling Author Dr. Michael Greger Officially Releases New Sustainable Weight Loss Book - HOW NOT TO DIET | PR Newswire | 12/10/2019

… the ideal weight-loss diet—factors such as calorie density, the insulin index, and the impact of foods on the gut microbiome—showing how plant-based eating is crucial to overall health. How Not to … is a graduate of Cornell University School of Agriculture and Tufts University School of Medicine . All proceeds received from his books, DVDs, and speaking engagements are all donated to charity. NutritionFacts.org is a strictly non …

Food and Drug Administration

MaaT Pharma Announces the Presentation of Positive Data with Its Lead Microbiome Biotherapeutic in Intestinal-Predominant Acute Graft-versus-Host-Disease at the ASH 2019 Annual Meeting | Benzinga | 12/8/2019

… where there are no other available treatments after steroids and additional lines of treatment. These findings indicate that reestablishing the gut microbiome improved outcomes in these patients.” Moreover, MaaT Pharma is currently conducting the HERACLES … MaaT013 has been granted Orphan Drug Designation by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) and is already being administered in compassionate use. About MaaT Pharma MaaT Pharma, a …

MaaT Pharma Announces the Presentation of Positive Data with Its Lead Microbiome Biotherapeutic in Intestinal-Predominant Acute Graft-versus-Host-Disease at the ASH 2019 Annual Meeting | Business Wire | 12/8/2019

… where there are no other available treatments after steroids and additional lines of treatment. These findings indicate that reestablishing the gut microbiome improved outcomes in these patients.” Moreover, MaaT Pharma is currently conducting the HERACLES … MaaT013 has been granted Orphan Drug Designation by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) and is already being administered in compassionate use. About MaaT Pharma MaaT Pharma, a …

Human Microbiome

Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection | Nature | 12/4/2019

… these dysbiotic states with pathogenic bacteria can lead to infectious complications beyond C. difficile infection. Taur et al. investigated the gut microbiome profiles of 94 bone marrow transplant recipients and reported that elevated gut Enterococcus … Fisherbrand Commode Specimen Collection kit which was used in the Human Microbiome Project 29 and which, by design, minimizes cross-contamination of urine in fecal specimens 30 . We also highlight the significant difference in bacterial …

Potato power - Winnipeg Free Press | 12/2/2019

… any chronic inflammatory condition you can think of — from inflammatory bowel disease to diabetes — research has shown changes to the gut microbiome are associated with their development,” says registered dietitian Natasha Haskey, a PhD candidate … step among several toward an overarching goal of understanding the human microbiome and personalizing nutrition to promote better health. “Basically this speaks to the idea there is no one diet that fits everyone.” While it’s …

Brain Health

The calorie is out, and qualitative eating is in. Finally. | 12/4/2019

… gut microbiome, making 100 calories of sugar not at all equivalent to 100 calories of whole grains or cruciferous vegetables when it comes to your gut. Cording also predicts the discussion around food’s effects on our brain health to become more mainstream. “Choline might be the next hot thing,” she says, referring to a nutrient found in eggs and other foods that helps the brain regulate memory and mood . Again …

Can You Eat to Beat Depression? | WebMD | 12/2/2019

… research, scientists aren’t sure how your diet affects your mental health. But they’re zeroing in on one promising area: your gut microbiome . “Of the more than 20 studies we are currently running at the Food … treat depression and may be important for other aspects of brain health, such as dementia . This is true for people across the lifespan – even very young children.” And if you do decide to adjust your …

NIH

What Are Microbes? | 12/4/2019

… is a term often used to describe the microorganisms that make up specific areas within the body. For example, your gut microbiome would be different than the microbiome of your skin. Microbial cells are another … organs interaction with herbs, thanks to those trusty microbes. The NIH Human Microbiome Project Scientists are still studying the human microbiome today, which is mainly done through the Human Microbiome Project . This study has produced …

Cats communicate with the help of bacteria living in their butts | 12/2/2019

… gut microbiome, and they decided to pursue an unconventional route to fund their research, using Kickstarter to seek help from the general public. Ganz is one of the authors of a report on how crowdfunding research can fill in funding gaps when resources from organisations like the National Institutes of Health (NIH) are hard to come by. KittyBiome reached their funding goal , and involved their citizen scientist backers in the …

Institutional Review Board

Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection | Nature | 12/4/2019

… these dysbiotic states with pathogenic bacteria can lead to infectious complications beyond C. difficile infection. Taur et al. investigated the gut microbiome profiles of 94 bone marrow transplant recipients and reported that elevated gut Enterococcus … recipients provided at least 1 fecal specimen. The Weill Cornell Institutional Review Board approved this study and each subject gave written informed consent. No organs were procured from prisoners and all kidney transplant recipients were …

Digbi Health’s Gut Biome and DNA-Based Weight Loss and Diabetes Management Program Launches with Blue Shield of California | PR Newswire | 11/25/2019

… their health. Digbi Health’s availability on the Wellvolution platform gives Blue Shield members access to a powerful, proven, DNA and gut microbiome-based precision care and personalized lifestyle medicine tool that is tailored to their … providers, and insurance companies. Digbi Health is currently conducting three Institutional Review Board approved human studies. Learn more at www.digbihealth.com . Or follow us on LinkedIn , Facebook or Twitter . SOURCE Digbi Health …

Viome

Drugs From Bugs: Why Gates, Zuck And Benioff Think The Next Blockbusters Will Come From Inside Your Gut | Forbes | 2/7/2020

… prone to C. diff since antibiotic treatment for other maladies decimates the infection-fighting capacity of what scientists call the gut microbiome, the trillions of cells that move through the human digestive system. “It didn’t … make no specific claims about diagnosing or treating particular diseases. Viome founder Naveen Jain. Tim Pannell for Forbes Four years ago, former InfoSpace billionaire Naveen Jain, 60, launched Bellevue, Washington–based Viome , which sells a …

Global Direct to Consumer Microbiome Analyzing Market Size, Status and Forecast 2020-2026 | 1/24/2020

… America. The key players covered in this study - UBiome, Inc. Market segment by Type, the product can be split into - Gut Microbiome Test Kits Market segment by Application, split into - Infections Market segment by Regions … Microbiome Analyzing Business (2015-2020)) 13.1.5 UBiome, Inc. Recent Development 13.2 Viome, Inc. 13.2.1 Viome, Inc. Company Details 13.2.2 Viome, Inc. Business Overview and Its Total Revenue 13.2.3 Viome, Inc. Direct to Consumer Microbiome Analyzing Introduction …

HealthDay

Science X Newsletter Tuesday, Feb 4 | 2/5/2020

… advancing or spreading squamous cell carcinoma and as a target for new therapies. Costs of ART regimens increasing, outpacing inflation (HealthDay)—Initial regimens recommended for most people with HIV (PWH) are priced above $36,000 per … widely used pesticide atrazine leads to heritable changes in the gut microbiome of wasps, finds a study publishing February 4 in the journal Cell Host & Microbe. Additionally, the altered microbiome confers atrazine resistance, which is …

Curious about probiotics? Tread carefully | 2/2/2020

… she said. One area where probiotics may be helpful is in maintaining the body’s natural balance of beneficial bacteria—the gut microbiome. “We know the human microbiome is incredibly important to our health and the … Responsible Nutrition; Jan. 15, 2020, Frontiers in Medicine Copyright ©2020 HealthDay . All rights reserved …

National Medical Products Administration

China Approves Seaweed Sugar as New Alzheimer’s Drug | 1/12/2020

… Stroke March 2017 China Approves Seaweed Sugar as New Alzheimer’s Drug Shanghai Green Valley Pharmaceuticals (Green Valley) announced that China’s National Medical Products Administration (NMPA) has approved Oligomannate (GV-971) as new drug for the … preclinical data “supports the emerging idea that modulation of the gut microbiome via treatments such as GV-971 or other strategies should be further explored as novel strategies to slow the progression of AD”. Oligomannate …

Curiosity, Skepticism Over New Algae-Derived Alzheimer’s Drug | Medscape | 11/14/2019

National Medical Products Administration for mild-to-moderate AD. Oligomannate is a drug manufactured from an oligosaccharide extracted from marine algae and is the first novel drug approved for AD globally since 2003, the company said in a press release. It’s expected to be available in China by the end of the year. The drug works on the gut microbiome. It reportedly reconditions dysbiosis of gut microbiota, inhibits the abnormal …

Qiagen

Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection | Nature | 12/4/2019

… these dysbiotic states with pathogenic bacteria can lead to infectious complications beyond C. difficile infection. Taur et al. investigated the gut microbiome profiles of 94 bone marrow transplant recipients and reported that elevated gut Enterococcus … The DNA was further purified using QIAamp mini spin columns (Qiagen, Hilden, Germany). For each sample, duplicate 50 μL PCR reactions were performed, each containing 50 ng of purified DNA, 0.2 mM dNTPs, 1.5 mM …

The impact of storage conditions on human stool 16S rRNA microbiome composition and diversity | 12/2/2019

… time-to-freezing on gut microbiota profiles is therefore an important consideration for field studies in tropical LMIC, where the gut microbiome composition is less well established, temperature variation is more difficult to control, and … the weighing process. Samples were homogenised using a TissueLyser II (Qiagen, Hilden, Germany) at a speed setting of 25, and a 2 min centrifugation was used after addition of binding matrix. DNA concentration was quantified …

Arivale

Nutrition Gets Personal | 12/4/2019

… nutrient levels in your blood or sweat. Other forms of data include an individual’s genetic makeup or the increasingly popular gut microbiome, which refers to the microbial community that resides in our gut. “There is … for a service that could not provide a clear benefit. Arivale, a US start-up that sought to combine genetic testing with personal coaching to improve health, shows how important it is to have a …

How Old Are You? Your Body Might Disagree With That Answer | PRWeb | 11/23/2019

… may be improved.” The study sampled men and women who varied by age and health status and who participated in Arivale (now closed), which was a consumer data-intensive “scientific wellness” program. The wellness program … ISB findings, notably that the alpha diversity of an individual’s gut microbiome can be accurately predicted by examining metabolites in the blood, and that combining personal, dense, dynamic data (PD3) clouds with tailored behavioral coaching …

Thermo Fisher Scientific

The impact of storage conditions on human stool 16S rRNA microbiome composition and diversity | 12/2/2019

… time-to-freezing on gut microbiota profiles is therefore an important consideration for field studies in tropical LMIC, where the gut microbiome composition is less well established, temperature variation is more difficult to control, and … matrix. DNA concentration was quantified using a NanoDrop 1000 fluorimeter (Thermo Fisher Scientific, Waltham, MA, USA). 16S library preparation A modification of the Illumina 16S metagenomic sequencing library preparation protocol ( https://support.illumina.com/documents/documentation/chemistry …

Diagnostic Deals: The Fate of Illumina-PacBio Merger Hangs in the Balance | 11/30/2019

… patients with certain solid tumors, to run on Illumina’s NextSeq 550Dx system Lexent responsible for securing regulatory approvals + commercializing kit Thermo Fisher Scientific Owlstone Medical Objective: Discover + validate early cancer detection biomarkers by noninvasive breath … service in Australia that uses shotgun metagenomics to analyze customers’ gut microbiomes + generate a personalized report DISTRIBUTION, SALES & MARKETING AGREEMENTS …

Biogen

Monthly Research Review – November 2019 | 12/1/2019

… Alpha Synuclein Antisense A manuscript was posted on the OPEN ACCESS preprint database BioRxiv by the biotech firms ionis Pharma & Biogen and researchers from Michigan State University, which demonstrates antisense oligonucleotides targeting alpha synuclein mRNA … oh & the researchers observed cell-to-cell transmission! ). 6. PD Gut microbiome points towards bile acids Researchers conducted longitudinal metabolome analysis on 30 drug-naive, de novo Parkinson’s patients (& 30 matched controls) and revealed PD …

A Discontinued Alzheimer’s Trial Comes Alive Again. Will Biogen’s Aducanumab Survive the FDA Review? | 11/19/2019

A Discontinued Alzheimer’s Trial Comes Alive Again. Will Biogen’s Aducanumab Survive the FDA Review? Posted on: Subscribe If approved, aducanumab would be the first disease-modifying drug to treat Alzheimer’s disease, plus the first to … for their candidate, oligomannate. The drug works by balancing the gut microbiome, which in turn reduces amyloid beta deposition and leads to improved cognitive function. While the FDA rounds up their Peripheral and Central Nervous …

Thermo Fisher

Diagnostic Deals: The Fate of Illumina-PacBio Merger Hangs in the Balance | 11/30/2019

… patients with certain solid tumors, to run on Illumina’s NextSeq 550Dx system Lexent responsible for securing regulatory approvals + commercializing kit Thermo Fisher Scientific Owlstone Medical Objective: Discover + validate early cancer detection biomarkers by noninvasive breath … service in Australia that uses shotgun metagenomics to analyze customers’ gut microbiomes + generate a personalized report DISTRIBUTION, SALES & MARKETING AGREEMENTS …

Blueberry Attenuates Liver Fibrosis, Protects Intestinal Epithelial Barrier, and Maintains Gut Microbiota Homeostasis | 11/22/2019

… was monitored by ALT and AST activity, protein and mRNA were determined by western blot and RT-qPCR, and the gut microbiome was detected by Miseq. Results . The results showed that blueberry could reduce the … on an ABI 7900 Real-Time PCR system (Applied Biosystems; Thermo Fisher Scientific, Inc.). The following primer pairs were used for qPCR: claudin1: forward, 5′-GGACAACATCG TGACTGCTC-3′ and reverse, 5′-CCCAGCAGG ATGCCAATTAC-3′; claudin2 …

Novartis

Gut microbiome and CAR-T therapy | 11/19/2019

… malignancies (HM). Despite impressive outcomes in select patients, there remains significant heterogeneity in clinical response to CAR T-cells. The gut microbiome has emerged as one of the key host factors that could potentially be … cells directed against CD19 [CD19+ CAR T-cells; tisagenlecleucel (Kymriah™, Novartis)] in August 2017 to treat acute lymphoblastic leukemia (ALL) and then axicabtagene ciloleucel (Yescarta™, Kite Pharma) R/R large B-cell lymphoma in October …

Herd health: agriculture’s role in the global AMR crisis | 11/13/2019

… materials of the animal-focused pharmaceutical companies – many of which are divisions or spin-outs from mainstream pharma giants like Novartis, Merck and Pfizer – that sell medical products to farmers. Are drugmakers advertising their products … as prebiotics and probiotics to promote healthy bacteria in animals’ gut microbiomes. Even gene editing, a new frontier even in human health, is starting to emerge as a potential solution to some issues. In June …

Pfizer

Lung and Gut Microbiota as Potential Hidden Driver of Immunotherapy Efficacy in Lung Cancer | 11/11/2019

… PD-(L)1 and anti-Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) agents [ 15 , 16 ]. Several studies demonstrated that the gut microbiome regulates the power by which immunotherapy may stimulate the anticancer immune response (reviewed … received honoraria or speakers’ fee from MSD, Astra-Zeneca, Celgene, Pfizer, Helsinn, Eli-Lilly, BMS, Novartis, and Roche; E.B. also received research grants from I.A.S.L.C. (International Association for the Study of Lung Cancer), L.I.L.T. (Lega …

Seaweed-based Alzheimer’s drug just approved. It’s the first new one in 17 years | fox8.com | 11/6/2019

… Valley. “These results advance our understanding of the mechanisms that play a role in Alzheimer’s disease and imply that the gut microbiome is a valid target for the development of therapies,” neurologist Philip Scheltens, who … a large clinical trial for the drug. Johnson & Johnson, Merck, Pfizer and Eli Lilly have all previously abandoned projects to develop a drug for Alzheimer’s after unsatisfactory clinical data. 35.861660 104.195397 …

8VC

2019 closes the year with 251 digital health fundings | MobiHealthNews | 12/31/2019

… human and machine intelligence to take care of its members on a daily basis.” Q2 Series B $65 Redpoint Ventures, 8VC, Echo Health Ventures, StartUp Health, Sidewalk Labs, Thrive Capital, Maverick Ventures, Town Hall Ventures … DayTwo’s platform asks patients to send a sample of their gut microbiome to the company’s lab, where it is sequenced and characterized alongside blood test results and a user questionnaire. These results are delivered back …

Digital health investments bounced back in Q2 2019 with nearly $2.5B in funding | MobiHealthNews | 7/5/2019

… with human and machine intelligence to take care of its members on a daily basis.” Series B $65 Redpoint Ventures, 8VC, Echo Health Ventures, StartUp Health, Sidewalk Labs, Thrive Capital, Maverick Ventures, Town Hall Ventures … DayTwo’s platform asks patients to send a sample of their gut microbiome to the company’s lab, where it is sequenced and characterized alongside blood test results and a user questionnaire. These results are delivered back …

Johns Hopkins University School of Medicine

Treating multiple sclerosis with the help of the gut microbiome | FierceBiotech | 12/2/2019

… gut microbiome has been credited with producing an anti-inflammatory response in MS. Earlier this year, researchers from the University of California, San Francisco and the University of Toronto demonstrated that microbes in the gut activate plasma cells, which in turn produce anti-inflammatory antibodies in the central nervous system. Targeting the gut microbiome could prove useful in treating other brain diseases, like Parkinson’s. A team at the Johns Hopkins …

New evidence of a link between Parkinson’s disease and the gut could inspire treatments | FierceBiotech | 6/26/2019

Mounting evidence is pointing to an association between the gut and Parkinson’s disease. New research coming out of Johns Hopkins University School of Medicine has added some weight to the connection and offered a new … netted $25 million to fund its programs that target the gut microbiome to treat Parkinson’s and autism. New York-based Kallyope is also leveraging the gut-brain axis to find small molecules for metabolic and …

Mayo Clinic

Cardiovascular effects of prolonged exercise | 11/23/2019

… endurance exercise.” Missouri medicine 109.4 (2012): 312. O’Keefe, James H., et al. “Potential adverse cardiovascular effects from excessive endurance exercise.” Mayo Clinic Proceedings. Vol. 87. No. 6. Elsevier, 2012. You May Like! Cardiovascular effects of … College of Sports Medicine Conference – 2017 Impacts of Exercise, the Gut Microbiome/Metabolome and Immunity on the Brain Julia Basso – PhD… Day 3 of the American College of Sports Medicine Conference – 2017 Neurobiological Effects of …

Can Fecal Microbiota Transplant (FMT) Aid in Cancer Treatment? | PR Newswire | 11/21/2019

… Therapies On March 28-29 , 2020, Yinghong Wang , MD, PhD, MS from MD Anderson Cancer Center will present Implications of the Gut Microbiome in Cancer and Therapeutic Potential at the Malibu Microbiome Meeting (MMM) in Malibu … Allegretti ( Harvard ), James Adams ( Arizona ), Faming Zhang ( China ), Sahil Khanna (Mayo Clinic), Alex Khoruts ( Minnesota ), Yinghong Wang (MD Anderson), Mazen Noureddin (Cedars-Sinai), Scott Jackson (NIST), Howard Young (NIH), Sabine Hazan (Progenabiome), and Zain Kassam …

Providence St. Joseph Health

How Old Are You? Your Body Might Disagree With That Answer | PRWeb | 11/23/2019

… consent from program participants. This study builds on other important ISB findings, notably that the alpha diversity of an individual’s gut microbiome can be accurately predicted by examining metabolites in the blood, and that combining … in real-world clinical impacts. ISB is an affiliate of Providence St. Joseph Health, one of the largest not-for-profit health care systems in the United States. Share article on social media or email …

How Old Are You? Your Body Might Disagree With That Answer | Markets Insider | Business Insider | 11/23/2019

… consent from program participants. This study builds on other important ISB findings, notably that the alpha diversity of an individual’s gut microbiome can be accurately predicted by examining metabolites in the blood, and that combining … in real-world clinical impacts. ISB is an affiliate of Providence St. Joseph Health, one of the largest not-for-profit health care systems in the United States . SOURCE Institute for Systems Biology …

NYU Langone Health

Advances in Gut Microbiota of Viral Hepatitis Cirrhosis | 11/22/2019

… Institute of Infectious Disease, Peking University Ditan Teaching Hospital, Beijing, China 2 Division of Gastroenterology and Hepatology, Department of Medicine, NYU Langone Health, New York University School of Medicine, New York, NY, USA 3 Department … caused by long-term liver injury [ 1 ]. Recently, research about gut microbiome has emerged in liver disease fields. Samples are often derived from saliva, mucous, feces, and lavage fluids. A variety of study methods has …

Surprising Symptoms of Gut Problems | Livestrong.com | 10/24/2019

Your gut microbiome is a complex ecosystem made up of billions of microorganisms. When your good intestinal flora are flourishing, all is groovy with your gut (and your overall health). But when you have gut … into ethanol, says Lee Ann Chen, MD , a gastroenterologist at NYU Langone Health, who goes on to explain that “affected individuals become drunk despite not actually ingesting any alcohol.” The authors of the BMJ report …

Memorial Sloan Kettering Cancer Center

Rutgers Center for Lipid Research holds 2019 Symposium | 11/20/2019

… Harini Sampath (Rutgers) spoke about a novel role for intestine-derived lipids in regulating whole body energy balance and the gut microbiome. She was followed by Chumin Lo (Ohio University) discussed the function of apo … drew researchers from Drexel University, NYU, Brooklyn College, Columbia University, Memorial Sloan Kettering Cancer Center, SUNY Downstate Medical Center, NeuroLipid Research Foundation and local pharmaceutical companies. The RCLR is a center of the New Jersey …

Gut microbiome and CAR-T therapy | 11/19/2019

… malignancies (HM). Despite impressive outcomes in select patients, there remains significant heterogeneity in clinical response to CAR T-cells. The gut microbiome has emerged as one of the key host factors that could potentially be … collaborative, multicenter efforts. Studies are now being conducted at the Memorial Sloan Kettering Cancer Center and the Medical College of Wisconsin to analyze any potential association of gut microbiota diversity/composition and response to CAR …

Cleveland Clinic

AHA News: Quitting Smoking Could Lead to Major Changes in Gut Bacteria | 11/19/2019

… significant piece of science,” said the study’s lead author, Dr. Marcus Sublette. “It’s already been established that smoking changes the gut microbiome. What we’re adding here is that smoking cessation itself will continue to change … director of the Center for Microbiome & Human Health at the Cleveland Clinic, said the study results “hint at the need to take a global view of one’s metabolism, including the gut microbial community within.” Hazen …

NIH awards Cleveland Clinic $12 M to study link between gut microbes, heart disease | 11/19/2019

… Ph.D., Mark Brown, Ph.D., and their teams will continue to study the role of microbial pathways and cardiometabolic diseases Credit: Cleveland Clinic CLEVELAND: The National Institutes of Health has awarded more than $12 million to … first Program Project grants funded by NIH focused on the gut microbiome, a rapidly growing field that shows numerous links to human health and disease. The award is from the National Heart, Lung and Blood …

Cleveland Clinic, Cleveland OH

NIH awards Cleveland Clinic $12 M to study link between gut microbes, heart disease | 11/19/2019

… Ph.D., Mark Brown, Ph.D., and their teams will continue to study the role of microbial pathways and cardiometabolic diseases Credit: Cleveland Clinic CLEVELAND: The National Institutes of Health has awarded more than $12 million to … first Program Project grants funded by NIH focused on the gut microbiome, a rapidly growing field that shows numerous links to human health and disease. The award is from the National Heart, Lung and Blood …

Cleveland Clinic receives NIH grant to study link between gut microbes, cardiometabolic diseases | 11/19/2019

The National Institutes of Health has awarded more than $12 million to Cleveland Clinic researchers to study the critical link between gut microbial pathways and the development of cardiometabolic diseases. The team is led by … first Program Project grants funded by NIH focused on the gut microbiome, a rapidly growing field that shows numerous links to human health and disease. The award is from the National Heart, Lung and Blood …

Michigan Medicine

The Michigan Medicine blog recap | 11/8/2019

November 8, 2019 // FOUND IN: Michigan Medicine News A weekly roundup of articles from both the Michigan Health and Michigan Health Lab blogs, which cover stories on breaking news and research, health tips and wellness … Disease Michigan Medicine researchers discover how bad bacteria overtake the gut microbiome in Crohn’s disease. READ MORE Toilet Sign Series Parkinson’s Disease and Your Bladder Many diagnosed with Parkinson’s disease experience urinary tract issues. Here …

E. coli gain edge by changing their diets in inflammatory bowel disease | Phys Org | 11/5/2019

… gut microbiome , composed of the trillions of bacteria that make their home inside the intestines, are key players. In a new paper in Nature Microbiology , Michigan Medicine researchers describe how bad bacteria gain a foothold over good bacteria in IBD and how something as simple as a diet change might reverse it. “The same bacteria are present in healthy and inflamed digestive tracts,” says Nobuhiko Kamada, Ph.D., of the division …

Harvard Medical School

Wikileaks Document Reveals a “Secret US Base on the Moon” (VIDEO) | 11/3/2019

… of meat raises the risk of heart disease and cancer, when compared with a vegetarian diet.” Dr. Deepak Bhatt, a Harvard Medical School professor and Editor-in-Chief of the Harvard Heart Letter ( source ) A … a meat-containing meal, because they have a totally different gut microbiome. It takes only a few days for our gut bacterial patterns to change – the benefits of a plant-based diet start quickly!” – Michelle …

Beth Israel Deaconess Medical Center

Scientists Find Chronic Brain Inflammation in Children With Autism | 10/30/2019

… Response Targeting Brain Cells in Autism In another study published in Annals of Neurology on Oct. 8, 2019, researchers at Beth Israel Deaconess Medical Center examining brains donated to Autism BrainNet, a non-profit tissue … ASD. Those researchers suggest that genetic variables and disruptions in gut microbiome might be a common factor in both ASD and IBD, and concluded that the possibility that both disorders share biological underpinnings merits exploration …

Metabolism And Gut Bacteria: What You Need To Know | 10/4/2019

… gut microbiome was for the first time studied comprehensively by researchers at Beth Israel Deaconess Medical Center (BIDMC). The human gut microbiome is a collective term used to refer to 1,000 odd bacteria inhabiting the gut, belonging to 160 bacteria species. This surprisingly has more of an impact on metabolism and obesity than one would imagine. Why is this? Diversity in the gut bacteria becomes compromised with a high intake …

George Church

Rejuvenation Roundup November 2019 | 12/2/2019

gut microbiome to increase production of butyrate and brain-derived neurotrophic factor (BDNF) in order to aid the brain and fight against age-related cognitive diseases. One Combination Gene Therapy Treats Multiple Age-Related Diseases : A team led by Dr. George Church has formulated a gene therapy that has successfully treated a mouse model of age-related diseases, including obesity and diabetes. We discussed this paper in this month’s Journal …

Harvard’s athlete-based next-generation probiotics technology licensed to FitBiomics | PR Newswire | 9/5/2019

… exclusive licensing agreement between Harvard’s Office of Technology Development (OTD) and FitBiomics. Wyss Institute researchers Jonathan Scheiman (shown here) and George Church developed the concept that the intestinal microbiome of elite athletes harbors higher number … harbor higher numbers of certain types of bacteria in their gut microbiomes (the commensal microbes populating the intestinal tract) that support or perhaps drive optimal levels of performance and recovery during and after challenging athletic …

Donald Trump

Science X Newsletter Thursday, Nov 14 | 11/15/2019

… England Journal of Medicine. Health groups urge president to ban all flavored e-cigarettes An ad campaign urging U.S. President Donald Trump to follow through on a commitment to ban all flavored electronic cigarettes, including … New process kills mosquito larvae using bacteria in the male’s gut microbiome A team of undergraduate student researchers at Ben-Gurion University of the Negev (BGU), who competed in the 2019 iGem competition, have developed …

11 November - Blogs I’m Following - 2 of 5 | 11/12/2019

… D.O., Ph.D. Story at-a-glance Recent data show that the fat-soluble hormone known as vitamin D modulates your gut microbiome, creating a healthier environment. This is likely one of the reasons sunlight has … ice age in 1979?? appeared first on Ice Age Now. Donald Trump Jr. Talk Marked By Anger Over No Q&A AP News at Snopes.com - 9 hours ago Members of the audience of about 450 …

Jeffrey Cummings

China Approves Seaweed Sugar as First New Alzheimer’s Drug in 17 Years | 11/8/2019

… 2020, in United States, Europe, China. A single Phase 3 study apparently found that GV-971, reported to alter the gut microbiome, slowed cognitive decline in people with AD. The trajectory of cognitive change in … is slightly larger than differences reported for cholinesterase inhibitors, said Jeffrey Cummings of the Cleveland Clinic, Lou Ruvo Center for Brain Health in Las Vegas, who is a scientific adviser to Green Valley. Separation between …

Shanghai Green Valley announces NMPA approval of oligomannate for Mild to Moderate Alzheimer’s Disease | 11/8/2019

… University in St. Louis and his colleagues wrote that the preclinical data “supports the emerging idea that modulation of the gut microbiome via treatments such as GV-971 or other strategies should be further explored … approved in many years and we applaud this innovation,” said Jeffrey Cummings, MD, Vice Chair for Research and Research Professor of UNLV Department of Brain Health and Professor and director of Center for Neurodegeneration and …

Fred Hutchinson

How Washington keeps America sick and fat - POLITICO | 11/4/2019

… it impossible for me and my colleagues to propose these types of studies,” said Kratz, who also works at the Fred Hutchinson Cancer Research Center in Seattle, where he studies dietary interventions and cancer prevention … cutting edge research on the relationship between diet and the gut microbiome — bacteria and fungi that naturally live inside the intestines of both humans and livestock. (Adams declined to comment on budgetary politics, even though …

Naveen Jain

Viome Named to the 2019 CB Insights Digital Health 150, List of Most Innovative Digital Health Startups | Globe Newswire | 10/3/2019

… optional by understanding the root cause of chronic diseases and pinpointing methods of prevention, beginning with the analysis of the gut microbiome. Viome applies advanced sequencing technology developed at the Los Alamos National Lab to … as ‘incurable’ for so long,” said Viome CEO and Founder Naveen Jain. “Viome is on a mission to challenge traditional healthcare perceptions and practices, and this acknowledgment from CB Insights validates that we’re on the …

Jessica Richman

Oops—Layoffs of lab staff at uBiome force the company to halt sample testing: reports | FierceBiotech | 7/11/2019

… report from Business Insider . The indefinite pause affects uBiome’s sole remaining offering—its direct-to-consumer Explorer test, which examines gut microbiome bacteria to provide information on wellness, food and lifestyle choices. uBiome previously halted … following FBI raid uBiome’s pair of founders and co-CEOs, Jessica Richman and Zac Apte, were placed on administrative leave in early May following the FBI’s search of its headquarters, where officers confiscated computers and …

John Green

For Novelist John Green, OCD Is Like An ‘Invasive Weed’ Inside His Mind | NPR | 6/28/2019

… thought that you’re able to have.” Originally broadcast Oct. 19, 2017. Hear The Original Interview Shots - Health News For Novelist John Green, OCD Is Like An ‘Invasive Weed’ Inside His Mind DAVID BIANCULLI, HOST: This … average per kiss,” endquote. After 6-month follow-up, human gut microbiomes appear to be modestly but consistently altered. (Reading) His bacteria would be in me forever, 80 million of them breeding and growing and …

For Novelist John Green, OCD Is Like An ‘Invasive Weed’ Inside His Mind : NPR | 6/28/2019

… thought that you’re able to have.” Originally broadcast Oct. 19, 2017. Hear The Original Interview Shots - Health News For Novelist John Green, OCD Is Like An ‘Invasive Weed’ Inside His Mind DAVID BIANCULLI, HOST: This … average per kiss,” endquote. After 6-month follow-up, human gut microbiomes appear to be modestly but consistently altered. (Reading) His bacteria would be in me forever, 80 million of them breeding and growing and …