Clinical Pharmacology

Selected news for the healthcare topic - Clinical Pharmacology, collected since 10/2017. Recent stories appear in rxdruglabels.com. This healthcare topic shares news with Food and Drug Administration, Clinical Data, Substance Abuse, Pfizer, Merck and over a hundred others.

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Date Headline (link) Source Relevant Snippet
2/19/2021 LUPRON DEPOT (leuprolide acetate) kit [AbbVie Inc.] National Institutes of Health Risk SummaryLUPRON DEPOT 3.75 mg is contraindicated in pregnancy [see Contraindications ( 4 ) ] .LUPRON DEPOT 3.75 mg may cause fetal harm based on findings from animal studies and the drug’s mechanism of action [see Clinical Pharmacology ( 12.1 ) ] . There are limited human data on the use of LUPRON DEPOT in pregnant women. Based on animal reproduction studies, LUPRON DEPOT 3.75 mg may be associated with an increased risk of pregnancy ...
2/17/2021 Butalbital, Acetaminophen and Caffeine - NuCare Pharmaceuticals,Inc. rxdruglabels.com ... opiate, non-salicylate analgesic and antipyretic. It has the following structural formula:Caffeine (1,3,7-trimethylxanthine), is a central nervous system stimulant. It has the following structural formula: butalbital chemical structureacetaminophen chemical structurecaffeine chemical structure CLINICAL PHARMACOLOGY This combination drug product is intended as a treatment for tension headache.It consists of a fixed combination of butalbital, acetaminophen and caffeine. The role each component plays in the relief of the complex ...
2/17/2021 Clobetasol Propionate - NuCare Pharmaceuticals,Inc. rxdruglabels.com ... clobetasol propionate USP 0.5 mg/g in a cream base of cetostearyl alcohol, chlorocresol, citric acid monohydrate, glyceryl monostearate, glyceryl stearate/ polyethylene glycol 100 stearate, propylene glycol, purified water, sodium citrate, and white wax. CLINICAL PHARMACOLOGY Like other topical corticosteroids, clobetasol propionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act ...
2/12/2021 Actionable Drug-Gene Interactions Common in U.K. Primary Care doctorslounge.com ... 56 drugsTell-a-FriendFRIDAY, Feb. 12, Actionable drug-gene interactions occur frequently in primary care in the United Kingdom, according to a study published online Jan. 19 in the British Journal of Clinical Pharmacology .Essra Youssef, from the University of East Anglia in the United Kingdom, and colleagues analyzed a large community pharmacy database to estimate the national incidence of first prescriptions for 56 drugs used in the ...
2/12/2021 LORAZEPAM tablet [NuCare Pharmaceuticals, Inc.] National Institutes of Health ... insoluble in water. Each Lorazepam Tablet, to be taken orally, contains 0.5 mg, 1 mg, or 2 mg of lorazepam. The inactive ingredients present are Lactose Anhydrous, Microcrystalline Cellulose, Polacrilin Potassium and Magnesium Stearate. CLINICAL PHARMACOLOGY Studies in healthy volunteers show that in single high doses Lorazepam has a tranquilizing action on the central nervous system with no appreciable effect on the respiratory or cardiovascular systems.Lorazepam is readily absorbed ...
2/12/2021 ACETAMINOPHEN AND CODEINE PHOSPHATE tablet [NuCare Pharmaceuticals, Inc.] National Institutes of Health ... mg (Warning: May be habit forming) In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, crospovidone, magnesium stearate, microcrystalline cellulose, povidone, pregelatinized starch, sodium lauryl sulfate, and stearic acid. CLINICAL PHARMACOLOGY Mechanism of Action Codeine is an opioid agonist relatively selective for the mu-opioid receptor, but with a much weaker affinity than morphine. The analgesic properties of codeine have been speculated to come from ...
2/12/2021 LORAZEPAM tablet [NuCare Pharmaceuticals, Inc.] National Institutes of Health ... insoluble in water. Each Lorazepam Tablet, to be taken orally, contains 0.5 mg, 1 mg, or 2 mg of lorazepam. The inactive ingredients present are Lactose Anhydrous, Microcrystalline Cellulose, Polacrilin Potassium and Magnesium Stearate. CLINICAL PHARMACOLOGY Studies in healthy volunteers show that in single high doses Lorazepam has a tranquilizing action on the central nervous system with no appreciable effect on the respiratory or cardiovascular systems.Lorazepam is readily absorbed ...
2/12/2021 LORAZEPAM tablet [NuCare Pharmaceuticals, Inc.] National Institutes of Health ... insoluble in water. Each Lorazepam Tablet, to be taken orally, contains 0.5 mg, 1 mg, or 2 mg of lorazepam. The inactive ingredients present are Lactose Anhydrous, Microcrystalline Cellulose, Polacrilin Potassium and Magnesium Stearate. CLINICAL PHARMACOLOGY Studies in healthy volunteers show that in single high doses Lorazepam has a tranquilizing action on the central nervous system with no appreciable effect on the respiratory or cardiovascular systems.Lorazepam is readily absorbed ...
2/12/2021 Reglan (Metoclopramide) - updated on RxList rxlist.com Therapy with reglan ®Administer from 10 mg to 15 mg reglan ® (metoclopramide hydrochloride, USP) orally up to q.i.d. 30 minutes before each meal and at bedtime, depending upon symptoms being treated and clinical response (see CLINICAL PHARMACOLOGY and INDICATIONS AND USAGEExperience with esophageal erosions and ulcerations is limited, but healing has thus far been documented in one controlled trial using q.i.d. therapy at 15 mg/dose, and ...
2/12/2021 VERAPAMIL HYDROCHLORIDE tablet, film coated, extended release [NuCare Pharmaceuticals, Inc.] National Institutes of Health ... Red and Ferric Oxide Black 240 Ferric Oxide Yellow, Ferric Oxide Red and Ferric Oxide BlackVerapamil hydrochloride extended-release tablets USP, 120 mg, 180 mg and 240 mg meet USP Dissolution Test 1. CLINICAL PHARMACOLOGY Verapamil hydrochloride is a calcium ion influx inhibitor (slow channel blocker or calcium ion antagonist) that exerts its pharmacologic effects by modulating the influx of ionic calcium across the cell membrane of the arterial ...
2/12/2021 ATENOLOL AND CHLORTHALIDONE tablet [NuCare Pharmaceuticals, Inc.] National Institutes of Health ... mg and chlorthalidone USP, 25 mg.Atenolol and Chlorthalidone Tablets USP, 50 mg-25 mg and 100 mg-25 mg, contain the following inactive ingredients: magnesium stearate, microcrystalline cellulose, povidone and sodium starch glycolate. CLINICAL PHARMACOLOGY Atenolol and Chlorthalidone Atenolol and chlorthalidone have been used singly and concomitantly for the treatment of hypertension. The antihypertensive effects of these agents are additive, and studies have shown that there is no interference ...
2/12/2021 ONDANSETRON tablet, orally disintegrating [NuCare Pharmaceuticals, Inc.] National Institutes of Health ... treatment [see Warnings and Precautions (5.3) ] . 7.2 Drugs Affecting Cytochrome P-450 Enzymes Ondansetron does not itself appear to induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system of the liver [see Clinical Pharmacology (12.3) ] . Because ondansetron is metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes (CYP3A4, CYP2D6, CYP1A2), inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life of ondansetron. In ...
2/12/2021 ENALAPRIL MALEATE tablet [NuCare Pharmaceuticals, Inc.] National Institutes of Health ... is indicated for the treatment of symptomatic congestive heart failure, usually in combination with diuretics and digitalis. In these patients enalapril maleate tablet improves symptoms, increases survival, and decreases the frequency of hospitalization (see CLINICAL PHARMACOLOGY , Heart Failure, Mortality Trials for details and limitations of survival trials).Asymptomatic Left Ventricular DysfunctionIn clinically stable asymptomatic patients with left ventricular dysfunction (ejection fraction ≤35 percent), enalapril maleate tablet decreases the ...
2/12/2021 BUMETANIDE tablet [NuCare Pharmaceuticals, Inc.] National Institutes of Health ... lake; 2 mg—red iron oxide.Chemically, bumetanide is 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid. It is a practically white powder having a calculated molecular weight of 364.42, and the following structural formula: CLINICAL PHARMACOLOGY Bumetanide is a loop diuretic with a rapid onset and short duration of action. Pharmacological and clinical studies have shown that 1 mg bumetanide has a diuretic potency equivalent to approximately 40 mg furosemide ...
2/12/2021 FAMOTIDINE tablet [NuCare Pharmaceuticals, Inc.] National Institutes of Health ... may need to be used in patients with moderate (creatinine clearance 50 mL/min) or severe (creatinine clearance 10 mL/min) renal insufficiency to adjust for the longer elimination half life of famotidine (see CLINICAL PHARMACOLOGY IN ADULTS and DOSAGE AND ADMINISTRATION ). Prolonged QT interval has been reported very rarely in patients with impaired renal function whose dose/dosing interval of famotidine may not have been adjusted appropriately. Drug Interactions ...
2/12/2021 BUTALBITAL, ACETAMINOPHEN, AND CAFFEINE tablet [NuCare Pharmaceuticals, Inc.] National Institutes of Health ... formula:Acetaminophen (4´-hydroxyacetanilide), is a non-opiate, non-salicylate analgesic and antipyretic. It has the following structural formula:Caffeine (1,3,7-trimethylxanthine), is a central nervous system stimulant. It has the following structural formula: CLINICAL PHARMACOLOGY This combination drug product is intended as a treatment for tension headache.It consists of a fixed combination of butalbital, acetaminophen, and caffeine. The role each component plays in the relief of the complex ...
2/12/2021 METOPROLOL TARTRATE tablet, film coated [NuCare Pharmaceuticals, Inc.] National Institutes of Health ... hypromellose, titanium dioxide, polyethylene glycol and polysorbate 80. In addition, 50 mg tablet contains D&C Red 30 Aluminium Lake and 100 mg tablet contains FD&C Blue 2 Aluminium Lake as coloring agents. CLINICAL PHARMACOLOGY Mechanism of Action Metoprolol tartrate is a beta 1 -selective (cardioselective) adrenergic receptor blocker. This preferential effect is not absolute, however, and at higher plasma concentrations, metoprolol also inhibits beta 2 -adrenoreceptors, chiefly located ...
2/12/2021 TIZANIDINE tablet [NuCare Pharmaceuticals, Inc.] National Institutes of Health ... Fluvoxamine Concomitant use of fluvoxamine and tizanidine is contraindicated. Changes in pharmacokinetics of tizanidine when administered with fluvoxamine resulted in significantly decreased blood pressure, increased drowsiness, and increased psychomotor impairment [see Contraindications (4) and Clinical Pharmacology ( 12.3) ]. 7.2 Ciprofloxacin Concomitant use of ciprofoxacin and tizanidine is contraindicated. Changes in pharmacokinetics of tizanidine when administered with ciprofloxacin resulted in significantly decreased blood pressure, increased drowsiness, and increased psychomotor impairment [See Contraindications ...
2/12/2021 METOPROLOL TARTRATE tablet, film coated [NuCare Pharmaceuticals,Inc.] National Institutes of Health ... hypromellose, titanium dioxide, polyethylene glycol and polysorbate 80. In addition, 50 mg tablet contains D&C Red 30 Aluminium Lake and 100 mg tablet contains FD&C Blue 2 Aluminium Lake as coloring agents. CLINICAL PHARMACOLOGY Mechanism of Action Metoprolol tartrate is a beta 1 -selective (cardioselective) adrenergic receptor blocker. This preferential effect is not absolute, however, and at higher plasma concentrations, metoprolol also inhibits beta 2 -adrenoreceptors, chiefly located ...
2/12/2021 KETOCONAZOLE shampoo, suspension [NuCare Pharmaceuticals,Inc.] National Institutes of Health ... No. 40, and purified water.Ketoconazole is cis -1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1 H -imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine and has the following structural formula: CLINICAL PHARMACOLOGY Tinea (pityriasis) versicolor is a non-contagious infection of the skin caused by Pityrosporum orbiculare (Malassezia furfur) . This commensal organism is part of the normal skin flora. In susceptible individuals the condition is often ...