Clinical Datasets

Bio-Statistician | 9/14/2020

… Innovation team and help to develop and validate complex statistical models, using multivariate data sets to draw targeted conclusions from noisy and non-uniform information. You will be working on a wide variety of clinical datasets , and on data sourced from various sequencing technologies, to generate insight into the genetic disease-causing mechanisms of genetics variants. Working as part of a multidisciplinary team, your analyses will be used by clinical …

Improving National Clinical Datasets for Health Equity Research | 9/9/2020

In spite of focused clinical, research, and policy efforts, great disparities in healthcare and outcomes persist. According to researchers, the key to solving many of these problems lies in making large clinical datasets more useful and informative for health disparities research. To this end the Health Disparities Collaborative Research Group was commissioned by the Patient-Centered Outcomes Research Institute to improve data science and quality around health disparities. The group …

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Datavant Enters into Two Real-World and Clinical Data Linking Agreements with Janssen R&D | BioSpace | 9/9/2020

… to build better medicines for patients. Under the first agreement 1 , Janssen R&D gains access to Datavant’s privacy-protecting linking technology to integrate disparate data sets to create rich, longitudinal real-world and clinical datasets to better understand the holistic patient journey, thereby enhancing the design and execution of Janssen’s clinical development programs for patients. Under the agreement, Datavant’s linking technology may be used for a variety of use …

vlpi 0.1.0 | 9/8/2020

… using pip by running the following command: pip install vlpi Use The software package is essentially broken into two sections. The first implements a data structure ( ClinicalDataset class) that efficiently stores and manipulates large clinical datasets . It is essentially a sparse binary array with added functionality that automates many tasks, such as constructing training and validation splits and converting among different symptom encodings. In addition, another class ( ClinicalDatasetSampler ) is used …

LifeTime and improving European healthcare through cell-based interceptive medicine | 9/7/2020

… be implemented through the development and integration of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during progression from health to disease. Analysis of such large molecular and clinical datasets will discover molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. Timely detection and interception of disease embedded in an ethical and patient-centered vision will be …

Recommendations for improving national clinical datasets for health equity research | 9/5/2020

Home Abstracts Journal Abstracts Recommendations for improving national clinical datasets for health equity research Recommendations for improving national clinical datasets for health equity research By J Am Med Inform Assoc. 2020 Sep 3:ocaa144. doi: 10.1093/jamia/ocaa144. Online ahead of print. ABSTRACT Health and healthcare disparities continue despite clinical, research, and policy efforts. Large clinical datasets may not contain data relevant to healthcare disparities and leveraging these for research …

Mayo Clinic COVID-19 News Media Coverage for September 2, 2020 | 9/2/2020

… weather impacts the body Healthcare IT News , Mayo Clinic and Google: COVID-19 shows the importance of data liquidity Healthcare IT News , MITRE working with Nuance and Mayo Clinic on AI and automation for clinical datasets Fierce Healthcare , Mayo Clinic study finds uptick in chest pain searches online amid COVID-19, even as ED visits for heart problems drops. Additional coverage: Becker’s Hospital Review Becker’s Hospital Review , Mayo Clinic, nonprofit …

Global healthcare needs to speak a common language to tackle the challenge of COVID-19 | Healthcare IT News | 8/27/2020

… of newly diagnosed cases in real-time and by centralising all test results helped policy-makers to more efficiently allocate resources for better capacity utilisation and care coordination in the Emirate. The standardisation of clinical datasets will further help improve the exchange of information between the different systems through Malaffi. Taking standardisation further Today, there are some datasets that are properly standardised, while others do not have a standardised coding …

MITRE working with Nuance, Mayo Clinic on AI and automation for clinical datasets | 8/26/2020

MITRE on Tuesday announced two new collaborations based around its mCODE data standard. One will bring voice recognition capabilities to the oncology dataset, and another will see it working with the Mayo Clinic to build out and automate that and other data platforms to enable better care for cardiology, COVID-19 and more. WHY IT MATTERS Nuance will work to advance MITRE’s co-developed mCODE data standard for improved cancer …

MITRE working with Nuance and Mayo Clinic on AI and automation for clinical datasets | Healthcare IT News | 8/26/2020

Dragon Medical One voice technology will be integrated with mCODE core data, enabling easier documentation within clinical workflows – and a new partnership with Mayo will explore automation opportunities. August 26, 2020 10:15 AM MITRE on Tuesday announced two new collaborations based around its mCODE data standard. One will bring voice recognition capabilities to the oncology dataset, and another will see it working with the Mayo Clinic to build out and …

MITRE working with Nuance and Mayo Clinic on AI and automation for clinical datasets | 8/26/2020

26 MITRE working with Nuance and Mayo Clinic on AI and automation for clinical datasets Healthcare IT News: MITRE on Tuesday announced two new collaborations based around its mCODE data standard. One will bring voice recognition capabilities to the oncology dataset, and another will see it working with the Mayo Clinic to build out and automate that and other data platforms to enable better care for cardiology, COVID-19 and …

Breast cancer gene expression datasets do not reflect the disease at the population level | 8/25/2020

… to provide valuable insights, particularly if they have detailed information on the tumor and patient characteristics. Gene expression data from functional studies in cancer cell lines or in vivo experiments can be compared with clinical datasets to evaluate the reliability of model systems to recapitulate the disease. These clinical datasets can also be used to assess associations between putative oncogenes or tumor suppressors and different signaling pathways or clinical characteristics …

Targetable ERBB2 mutation status is an independent marker of adverse prognosis in estrogen receptor positive, ERBB2 non-amplified primary lobular breast carcinoma: a retrospective in silico analysis of public datasets | 8/11/2020

… suggesting further acquisition of ERBB2 mutations in CDH1 -altered ILC due to the selective pressure of treatment [ 21 ]. To demonstrate the potential clinical benefit of targeting low frequency somatic mutations, prognostic analyses using large clinical datasets are required. In the MA12 trial comprising 328 premenopausal patients with ER+ primary breast cancer of all histological subtypes, non-silent ERBB2 mutations occurred in 5.2% of patients ( N  = 17) and were adversely prognostic …

Machine learning-based prediction of acute coronary syndrome using only the pre-hospital 12-lead electrocardiogram | 8/7/2020

… such models to real-world clinical settings remain questionable, and it is likely these algorithm were overfitting the data contained in the PTB dataset On the other hand, there were few studies that used clinical datasets to build ML classifiers. However, most of these studies combined classical ECG features (e.g., diagnostic ST–T amplitude changes) with a full range of other clinical data elements (e.g., patient history, physical exam abnormalities …

Eloxx Pharmaceuticals Reports Second Quarter 2020 Financial and Operating Results and Provides Business Update Nasdaq:ELOX | Globe Newswire | 8/6/2020

… codons found at the end of healthy transcripts is maintained. This indicates that translation integrity is preserved with target-therapeutic exposure of ELX-02, consistent with the favorable tolerability profile across our preclinical and clinical datasets . On June 17, 2020, we announced that enrollment in our cystic fibrosis Phase 2 clinical trial in Europe and Israel had been resumed, while the trial in the U.S. remains paused due to the …

Eloxx Pharmaceuticals Reports Second Quarter 2020 Financial and Operating Results and Provides Business Update | Globe Newswire | 8/6/2020

… codons found at the end of healthy transcripts is maintained. This indicates that translation integrity is preserved with target-therapeutic exposure of ELX-02, consistent with the favorable tolerability profile across our preclinical and clinical datasets . On June 17, 2020, we announced that enrollment in our cystic fibrosis Phase 2 clinical trial in Europe and Israel had been resumed, while the trial in the U.S. remains paused due to the …

Eloxx Pharmaceuticals Reports Second Quarter 2020 Financial and Operating Results and Provides Business Update | BioSpace | 8/6/2020

… codons found at the end of healthy transcripts is maintained. This indicates that translation integrity is preserved with target-therapeutic exposure of ELX-02, consistent with the favorable tolerability profile across our preclinical and clinical datasets . On June 17, 2020, we announced that enrollment in our cystic fibrosis Phase 2 clinical trial in Europe and Israel had been resumed, while the trial in the U.S. remains paused due to the …

Targeting RET Kinase in Neuroendocrine Prostate Cancer | 8/4/2020

… RET kinase, and RET kinase itself, were enriched and activated in the AR-independent cell lines when compared with AR-dependent cell lines. In addition, RET kinase was overexpressed in NEPC tumors in multiple clinical datasets . We found that the NEPC cell line, NCI-H660, was dependent on RET expression for proliferation and that targeted RET pathway inhibitors, AD80, and two other inhibitors currently being evaluated in the clinic, LOXO …

Pathnova Laboratories (PATHNOVA) Enters into Partnership to Commercialize Todos Medicals COVID-19 and Breast Cancer Tests in Singapore | Globe Newswire | 8/3/2020

… of the Todos Tests in Singapore, and Todos will assist PATHNOVA in commercializing its nasopharyngeal cancer tests through its affiliates in the United States and Singapore. Todos will provide PATHNOVA with access to existing clinical datasets for its breast cancer diagnostics TM-B1 and TM-B2, and PATHNOVA will work closely with Todos to optimize its AI-driven algorithm to support regulatory approval in the United States and Singapore. Reciprocally …

Pathnova Laboratories (PATHNOVA) Enters into Partnership to Commercialize Todos Medicals … | 8/3/2020

… of the Todos Tests in Singapore, and Todos will assist PATHNOVA in commercializing its nasopharyngeal cancer tests through its affiliates in the United States and Singapore. Todos will provide PATHNOVA with access to existing clinical datasets for its breast cancer diagnostics TM-B1 and TM-B2, and PATHNOVA will work closely with Todos to optimize its AI-driven algorithm to support regulatory approval in the United States and Singapore. Reciprocally …

Pathnova Laboratories (PATHNOVA) Enters into Partnership to Commercialize Todos Medicals COVID-19 and Breast Cancer Tests in Singapore | 8/3/2020

… of the Todos Tests in Singapore, and Todos will assist PATHNOVA in commercializing its nasopharyngeal cancer tests through its affiliates in the United States and Singapore. Todos will provide PATHNOVA with access to existing clinical datasets for its breast cancer diagnostics TM-B1 and TM-B2, and PATHNOVA will work closely with Todos to optimize its AI-driven algorithm to support regulatory approval in the United States and Singapore. Reciprocally …

Pathnova Laboratories (PATHNOVA) Enters into Partnership to Commercialize Todos Medicals COVID-19 and Breast Cancer Tests in Singapore | Benzinga | 8/3/2020

… of the Todos Tests in Singapore, and Todos will assist PATHNOVA in commercializing its nasopharyngeal cancer tests through its affiliates in the United States and Singapore. Todos will provide PATHNOVA with access to existing clinical datasets for its breast cancer diagnostics TM-B1 and TM-B2, and PATHNOVA will work closely with Todos to optimize its AI-driven algorithm to support regulatory approval in the United States and Singapore. Reciprocally …

Pathnova Laboratories (PATHNOVA) Enters into Partnership to Commercialize Todos Medicals COVID-19 and Breast Cancer Tests in Singapore | BioSpace | 8/3/2020

… of the Todos Tests in Singapore, and Todos will assist PATHNOVA in commercializing its nasopharyngeal cancer tests through its affiliates in the United States and Singapore. Todos will provide PATHNOVA with access to existing clinical datasets for its breast cancer diagnostics TM-B1 and TM-B2, and PATHNOVA will work closely with Todos to optimize its AI-driven algorithm to support regulatory approval in the United States and Singapore. Reciprocally …

Breaking News: Pathnova Laboratories (PATHNOVA) Enters into Partnership to Commercialize Todos Medicals COVID-19 and Breast Cancer Tests in Singapore | 8/3/2020

… of the Todos Tests in Singapore, and Todos will assist PATHNOVA in commercializing its nasopharyngeal cancer tests through its affiliates in the United States and Singapore. Todos will provide PATHNOVA with access to existing clinical datasets for its breast cancer diagnostics TM-B1 and TM-B2, and PATHNOVA will work closely with Todos to optimize its AI-driven algorithm to support regulatory approval in the United States and Singapore. Reciprocally …

Pathnova Laboratories (PATHNOVA) Enters into Partnership to Commercialize Todos Medicals COVID-19 and Breast Cancer Tests in Singapore | 8/3/2020

… of the Todos Tests in Singapore, and Todos will assist PATHNOVA in commercializing its nasopharyngeal cancer tests through its affiliates in the United States and Singapore. Todos will provide PATHNOVA with access to existing clinical datasets for its breast cancer diagnostics TM-B1 and TM-B2, and PATHNOVA will work closely with Todos to optimize its AI-driven algorithm to support regulatory approval in the United States and Singapore. Reciprocally …

Food and Drug Administration

The Law Offices of Frank R. Cruz Announces Investigation on Behalf of CytoDyn Inc. Investors (CYDY) | Business Wire | 7/2/2020

Food and Drug Administration for Leronlimab as a combination therapy with HAART for highly treatment experienced HIV patients.” Then, on May 7, 2020, CytoDyn announced that its BLA for Leronlimab “will be considered completed after the clinical datasets are submitted on May 11, 2020.” On this news, the Company’s share price fell as much as $0.225, or more than 7%, during intraday trading on May 8, 2020. On June 30 …

INVESTOR ALERT: Law Offices of Howard G. Smith Continues Investigation of CytoDyn Inc. (CYDY) on Behalf of Investors | Business Wire | 7/1/2020

Food and Drug Administration for Leronlimab as a combination therapy with HAART for highly treatment experienced HIV patients.” Then, on May 7, 2020, CytoDyn announced that its BLA for Leronlimab “will be considered completed after the clinical datasets are submitted on May 11, 2020.” On this news, the Company’s share price fell as much as $0.225, or more than 7%, during intraday trading on May 8, 2020. On June 30 …

NIH

CytoDyn Signs MOU With NIH of Mexico for Coronavirus Study - June 30, 2020 - Zacks.com | 6/30/2020

… Memorandum of Understanding (MOU) with the Coordinating Commission of the National Institutes of Health and High Specialty Hospitals of Mexico (NIH) to conduct a COVID-19 study on its investigational candidate, leronlimab. The study will … patients on Apr 27, 2020, and submitted additional FDA requested clinical datasets on May 11. CytoDyn Inc. Price CytoDyn Inc. price CytoDyn Inc. Quote Zacks Rank & Stocks to Consider CytoDyn currently carries a Zacks Rank …

CytoDyn and NIH of Mexico Complete Memorandum of Understanding to Conduct Small Covid-19 Phase 3 Trial for Severe and Critically Ill Patients | Globe Newswire | 6/29/2020

… announced today the Company and the Coordinating Commission of the National Institutes of Health and High Specialty Hospitals of Mexico (NIH) have entered into a Memorandum of Understanding (MOU) to conduct a COVID-19 clinical … FDA on April 27, 2020, and submitted additional FDA requested clinical datasets on May 11, 2020. After the FDA deems a BLA submission complete, it sets a PDUFA goal date. CytoDyn has Fast Track designation …

Mark Roth

Orchard Therapeutics’ (ORTX) CEO on Q3 2019 Results - Earnings Call Transcript | Seeking Alpha | 11/9/2019

… Therapeutics PLC (NASDAQ: ORTX ) Q3 2019 Earnings 7, 2019 4:30 PM ET Company Participants Renee Leck – Director of Investor Relations Mark Rothera – President and Chief Executive Officer Frank Thomas – Chief Financial Officer Bobby Gaspar – Chief … believe we have one of the most robust and comprehensive clinical datasets in the field of gene therapy …

Orchard Therapeutics plc (ORTX) Q1 2019 Earnings Call Transcript - Nasdaq.com | 5/28/2019

… obligation to update or revise any forward-looking statements. With that, I’ll turn the call over to President and CEO Mark Rothera. 10 stocks we like better than Orchard Rx Ltd When investing geniuses David … believe we have one of the most robust and comprehensive clinical datasets in the field of gene therapy. In addition, the Orchard team has a deep understanding of developing and commercializing medicines to treat rare …