Adverse Drug Reactions

Comparison of uric acid reduction and renal outcomes of febuxostat vs allopurinol in patients with chronic kidney disease | National Institutes of Health | 7/1/2020

… therapy (ULT) includes xanthine oxidase inhibitors (XOIs), such as allopurinol and febuxostat, and uricosuric agents, such as benzbromarone, probenecid, and sulfinpyrazone. Because allopurinol carries a life-threatening risk of HLA-B 58:01–mediated cutaneous adverse drug reactions in some Asian populations and CKD increases additional risk for allopurinol side effects, genotyping screening before allopurinol initiation 13 and starting at a lower dose then slowly titrating the dose upward to achieve …

Pharmacovigilance Literature Screening ser | Adverse drug re… | Flickr | 6/29/2020

Adverse drug reactions assume much significance in terms of risk associated with safety of patients and could make a major impact on costs related to health systems. Owing to its significant implications for public health and safety of patients, regulatory authorities around the world have enforced and put into practice novel legislations related to pharmacovigilance in recent times Visit: www.pepgra.com/what-we-do/global-and-local-literature-sea …

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Yarrow – A Thousand Leaves, A Thousand Cures | 6/29/2020

… injuries. Also, not to forget, Asteraceae are considered to be one of the most important families of allergenic plants in Europe. (Cf. Remedies Containing Asteraceae Extracts: A Prospective Observational Study of Prescribing Patterns and Adverse Drug Reactions ) They are the ‘Stars’ = lat. astera The well-defined symmetry of the flowers of this group speaks for itself. A star flower is not just ONE flower, but many flowers in ONE. The …

Frailty and the Risk of Polypharmacy in the Older Person: Enabling and Preventative Approaches | 6/29/2020

… physical activity [ 17 ]. Rockwood [ 7 ] operationalized a frailty index of 70 items characterized by many conditions (disability, cognitive and physical impairments, geriatric conditions, and psychosocial risks) that could lead to increased risk of developing adverse drug reactions (ADRs) [ 18 ].The physical manifesting factors or deficits of frailty are more likely to be identified and treated by clinicians than psychosocial factors, which raises concerns on the overall awareness of the issue …

[ASAP] XenoNet: Inference and Likelihood of Intermediate Metabolite Formation | 6/29/2020

Drug metabolism is a common cause of adverse drug reactions . Drug molecules can be metabolized into reactive metabolites, which can conjugate to biomolecules, like protein and DNA, in a process termed bioactivation. To mitigate adverse reactions caused by bioactivation, both experimental and computational screening assays are utilized. Experimental assays for assessing the formation of reactive metabolites are low throughput and expensive to perform, so they are often reserved until later …

1%]) For patients treated with | 6/27/2020

… 5 [1.4%] versus comparator 2 [0.6%]), dizziness (moxifloxacin 6 [1.7%] versus comparator 6 [1.7%]), increased ALT (moxifloxacin 9 [2.6%] versus comparator 8 [2.3%]), and rash (moxifloxacin 8 [2.3%] versus comparator 3 [0.9%]). Table IV Adverse drug reactions occurring in either treatment group in ≧0.5% of patients valid for the safety analysis, treated with moxifloxacin or a comparator and stratified by route of administration (oral only; intravenous followed by oral [sequential …

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The smart Trick of ghana pharmacies That Nobody is Discussing | 6/26/2020

… job done instantly with the physician if they have inquiries or possible considerations with regard to the medications you are having. They make sure you are at the lowest probable danger for overdoses and adverse drug reactions by trying to keep a detailed history of the medications you’re taking.During the thirteenth century, Ghanaians made their exceptional art of adinkra printing. Hand-printed and hand-embroidered adinkra clothing were built and …

EHRs with Machine Learning Deciphering Drug Effects In Pregnant Women | 6/26/2020

… the women’s offspring—an exercise that can be expedited with commonly used AI machine learning models like logistic regression. So says Vanderbilt undergraduate student Anup Challa, founding director of the investigative collaboration MADRE (Modeling Adverse Drug Reactions in Embryos). The group works in the emerging field of PregOMICS that applies systems biology and bioinformatics to study the efficacy and safety of drugs in treating a rising tide of obstetrical diseases …

Gabapentin-induced drug-seeking-like behavior: a potential role for the dopaminergic system | National Institutes of Health | 6/26/2020

… and overdose incidences reported by the Food And Drug Administration Adverse Events Reporting System (FAERS) between 2012 and 2016 is alarming and requires immediate attention from the regulatory authorities 2 . Similarly, in Europe, the adverse drug reactions (ADRs) system provided by The European Medicines Agency (EMA) reported that 4,301 cases from 90,166 GBP recipients between 2004 and 2015 had abused, misused, or were dependent on GBP 35 . Similarly, according to …

Pharmacovigilance Market Growth Statistics, Size Projection, Future Trends, Business Overview and COVID-19 Impact Analysis By 2025 | 6/25/2020

… projected to reach USD 10, 881.03 MN by 2025. The renowned research firm also states that the global pharmacovigilance market would register 14.1% CAGR throughout the forecast period. Increasing numbers of fatalities due to adverse drug reactions (ADRs) boost the pharmacovigilance market growth. The Global Pharmacovigilance Market size is growing continually. Market growth attributes to the growing clinical trials due to the rising drug discovery activities across the globe. Besides …

Eisai Receives Approval for Parkinson’s Disease Treatment Equfina in South Korea | Benzinga | 6/25/2020

… phase. Regarding the primary endpoint, safinamide increased the “on” time by 0.96 hours (95% CI: 0.56, 1.37, p 0.001) more than placebo, showing a statistically significant extension in “on” time. The most common three adverse drug reactions observed with patients with safinamide were dyskinesia, nausea and somnolence. Under the license agreement signed between Eisai and Meiji Seika Pharma Co., Ltd. in March 2017, Eisai obtained exclusive marketing rights for safinamide …

Identifying potentially inappropriate medication (PIM) use in geriatric oncology. | Physicians Weekly | 6/25/2020

Identifying potentially inappropriate medication (PIM) use in geriatric oncology. Jun 25, 2020 The median number of medications taken by adults aged 65 and older is four, but may be higher in older adults with cancer. A high number of prescribed medications increases risk for adverse drug reactions (ADRs), drug-drug interactions, drug-disease interactions, and overall healthcare utilization, emphasizing the need for frequent review of medications. There are many tools …

Open-source machine learning tool connects drug targets with adverse reactions: Predicting adverse reactions | 6/25/2020

… cannot predict all possible adverse effects, we hope that our work will help researchers spot potential trouble early on and develop safer drugs in the future,” Ietswaart said. Drug side effects, technically known as adverse drug reactions , range from mild to fatal. They may occur either when taking a drug as prescribed or as a result of incorrect dosages, interaction of multiple medicines or off-label use (taking a drug …

LEVOFLOXACIN tablet, film coated [Preferred Pharmaceuticals, Inc.] | National Institutes of Health | 6/25/2020

… the patient and increases the risk of the development of drug-resistant bacteria [see Patient Counseling Information (17)]. 6 ADVERSE REACTIONS 6.1 Serious and Otherwise Important Adverse Reactions The following serious and otherwise important adverse drug reactions are discussed in greater detail in other sections of labeling: • Disabling and Potentially Irreversible Serious Adverse Reactions [ see Warnings and Precautions (5.1)] • Tendinitis and Tendon Rupture [see Warnings and Precautions ( 5.2)] • Peripheral Neuropathy …

FLUOXETINE (fluoxetine hydrochloride) capsule [PD-Rx Pharmaceuticals, Inc.] | National Institutes of Health | 6/25/2020

… Johnson syndrome, thrombocytopenia 1 , thrombocytopenic purpura, ventricular tachycardia (including Torsades de Pointes–type arrhythmias), vaginal bleeding, and violent behaviors 1 . 1 These terms represent serious adverse events, but do not meet the definition for adverse drug reactions . They are included here because of their seriousness. As with all drugs, the potential for interaction by a variety of mechanisms (e.g., pharmacodynamic, pharmacokinetic drug inhibition or enhancement, etc.) is a possibility. 7.1 …

Machine Learning Method Identifies Adverse Drug Side Effects | HealthIT Analytics | 6/24/2020

… can range from mild to fatal, the researchers noted. Effects can occur either when taking a drug as prescribed or as a result of incorrect dosages , interaction of multiple medicines, or off-label use. Adverse drug reactions are responsible for two million hospitalizations in the US each year, the team stated, and occur during ten to 20 percent of hospitalizations. Over the years, researchers and providers have implemented many strategies …

Inlyta (Axitinib) - updated on RxList | 6/22/2020

… twice daily is recommended, the INLYTA dose may be increased to 7 mg twice daily, and further to 10 mg twice daily using the same criteria. Over the course of treatment, management of some adverse drug reactions may require temporary interruption or permanent discontinuation and/or dose reduction of INLYTA therapy [see WARNINGS AND PRECAUTIONS ]. If dose reduction from 5 mg twice daily is required, the recommended dose is 3 …

OLUMIANT (baricitinib) tablet, film coated [Eli Lilly and Company] | National Institutes of Health | 6/22/2020

Additional adverse drug reactions occurring in fewer than 1% of patients: acne. 6.2 Postmarketing Experience The following adverse reactions have been identified during post-approval use of OLUMIANT. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Skin and Subcutaneous Tissue Disorders : rash, swelling of the face, urticaria. 7 …

Job Announcement: Susanville Indian Rancheria – Pharmacist | 6/20/2020

… of the patients through the Pharmacy & Therapeutics Committee. Provides patient-oriented pharmaceutical care services including, but not limited to, the following services: Review of medication orders for appropriateness of therapy for specific diagnoses, potential adverse drug reactions , and drug interactions; Provides consultation to primary care providers concerning appropriateness of medication usage; Ensures appropriate preparation and labeling of prescriptions; and Provides patient consultation and education to ensure patient understanding and improve …

5% ophthalmic | 6/19/2020

by admin 5% ophthalmic solution reported in the 804 facilities surveyed (safety population: N = 6686) Adverse Drug Reactions According to Patient Demographics and Dosing Frequency of Levofloxacin Table III lists the ADRs reported during the post-marketing surveillance of levofloxacin 0.5% ophthalmic solution, according to patient demographics and the dosing frequency of levofloxacin. Of interest, the incidence of ADRs was significantly higher in females (0.82%) than in males (0.36%; p …

Daily UDCA Reduced Gallstone Formation in Gastric Cancer Patients Following Gastrectomy | Physicians Weekly | 6/19/2020

… group were 77% less likely to have develop gallstones compared with placebo at an OR of 0.23 (95% CI, 0.07-0.74; P =0.01), researchers noted. Importantly, “[n]o statistically significant differences in the incidence of adverse drug reactions were noted among the 3 groups,” they reported, with no serious adverse drug reactions seen during the entire study interval. As the authors pointed out, prophylactic cholecystectomy done in conjunction with gastrectomy has …

Examination of WHO/INRUD Core Drug Use Indicators at Public Primary Healthcare Centers in Kisii County, Kenya | 6/19/2020

… doses, for a suitable period of time, at the cheapest cost [ 1 ]. Inappropriate use of drugs is an issue of concern with so many undesirable consequences such as the increased incidences of drug resistance, adverse drug reactions , cost of drug therapy, wastage of resources, and reduced quality of drug therapy [ 2 ]. Therefore, irrational use of drugs leads to serious consequences, both in terms of healthcare and economics [ 3 ]. Irrational drug …

COVID-19 Outbreak-Global Pharmacovigilance Industry Market Report-Development Trends, Threats, Opportunities and Competitive Landscape in 2020 | 6/19/2020

… activities relating to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The focus of pharmacovigilance is on ADR (adverse drug reactions) and drug toxicity. Increasing number of adverse drug reactions (ADRs) imposes a significant burden on the healthcare system by extending patient morbidity under chronic condition.The Pharmacovigilance government policy and future influence on the industry. Detailed analysis about market status (2015-2020), enterprise competition …

[ASAP] Drug Induced Liver Injury (DILI). Mechanisms and Medicinal Chemistry Avoidance/Mitigation Strategies | 6/19/2020

Adverse drug reactions (ADRs) are a common cause of attrition in drug discovery and development and drug-induced liver injury (DILI) is a leading cause of preclinical and clinical drug terminations. This perspective outlines many of the known DILI mechanisms and assessment methods used to evaluate and mitigate DILI risk. Literature assessments and retrospective analyses using verified DILI-associated drugs from the Liver Tox Knowledge Base (LTKB) have been used …

Food and Drug Administration

FDA Accepts Genentech’s New Drug Application for Xofluza for the Treatment of Influenza in Children | Business Wire | 3/27/2020

… Mar 27, 2020– Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), today announced that the U.S. Food and Drug Administration (FDA) has accepted a New Drug Application (NDA) as well as … Xofluza was well tolerated in this study and no new adverse drug reactions were identified. About Xofluza ® (baloxavir marboxil) Xofluza is a first-in-class, one-dose oral medicine with an innovative proposed mechanism of …

Biosimilars

Lannett Announces Positive Results From Human Clinical Trial Of Biosimilar Insulin Glargine Versus US Lantus® | PR Newswire | 12/4/2019

… reference drug, US approved Lantus ® ,” said Kristin Arnold , PhD, Lannett’s vice president of research and development. “Importantly, our insulin glargine was safe and well tolerated, and no serious adverse events (SAEs) or serious adverse drug reactions related to the drug were observed during the study. In summary, the Phase I study, conducted in healthy volunteers, confirmed that biosimilar insulin glargine matches the reference biologic in terms of pharmacokinetics (PK) and …

Biotech

Pharmacovigilance and Drug Safety Software Market Share By Top Trends & Key Futuristic | Forecast To 2025 | 12/4/2019

… Market is estimated to grow at a higher CAGR by the completion of the prediction period. The growing occurrence of Adverse Drug Reactions [ADR] is likely to trigger the demand for pharmacovigilance (PV) software during … the source of Type of End Use could span BPOs, Biotech & Pharma companies, CROs, and others. The subdivision of CROs is likely to witness lucrative development for the duration of the prediction owing to growing …

Medication Management

Family Care Path Partners With OneOme To Add Pharmacogenomic Testing To Its Genetic Wellness Program | PR Newswire | 12/2/2019

… help them optimize medication selection for that person, minimize trial and error in the prescribing process, decrease the likelihood of adverse drug reactions and reduce potential healthcare costs. And only individuals most likely to benefit … this collaboration will showcase the benefits of pharmacogenomics – both for medication management and as part of a broader genomic wellness program.” About Family Care Path Family Care Path, Inc. was formed in 2016 as a …

Pharmacogenomic Testing

Family Care Path Partners With OneOme To Add Pharmacogenomic Testing To Its Genetic Wellness Program | PR Newswire | 12/2/2019

adverse drug reactions and reduce potential healthcare costs. And only individuals most likely to benefit from pharmacogenomic testing will actually be tested, using OneOme’s proprietary population evaluation algorithm. “OneOme’s RightMed Test is an ideal complement to our MyLegacy application,” said Dave McKee , President and CEO of Family Care Path. “This partnership brings a new and exciting dimension to our offering, while maintaining our focus on improving people’s health outcomes while …

Genomics

Family Care Path Partners With OneOme To Add Pharmacogenomic Testing To Its Genetic Wellness Program | PR Newswire | 12/2/2019

… help them optimize medication selection for that person, minimize trial and error in the prescribing process, decrease the likelihood of adverse drug reactions and reduce potential healthcare costs. And only individuals most likely to benefit … CEO. “We believe this collaboration will showcase the benefits of pharmacogenomics – both for medication management and as part of a broader genomic wellness program.” About Family Care Path Family Care Path, Inc. was formed in …

FHIR

Family Care Path Partners With OneOme To Add Pharmacogenomic Testing To Its Genetic Wellness Program | Yahoo News | 12/2/2019

… help them optimize medication selection for that person, minimize trial and error in the prescribing process, decrease the likelihood of adverse drug reactions and reduce potential healthcare costs. And only individuals most likely to benefit … such as Microsoft Cloud and both the SMART® and HL7® FHIR® open standards, to create applications that can seamlessly communicate with electronic health record systems. About OneOme OneOme, LLC, co-founded by Mayo Clinic, is …

Clinical Research

Global Pharmacovigilance & Drug Safety Software Market Report 2019-2027 | Driven by Rising Incidences of Adverse Drug Reactions & Globalization of Pharmacovigilance | Financial Buzz | 11/28/2019

adverse drug reactions (ADRs) and globalization of pharmacovigilance. However, expensive technology may limit the growth of the market to a certain extent. The pharmacovigilance (PV) and drug safety software are used to recognize the cause of drug withdrawal and helps to inhibit unnecessary future events. These software are beneficial to those involved in drug making process like clinical research organization and pharmaceutical companies. These software help companies to manage huge …

NIH

Latent Dirichlet Allocation in predicting clinical trial terminations | 11/27/2019

… with full financial and institutional support from national agencies such as the National Science Foundation (NSF), National Institute of Health (NIH), etc. One such study reported that about 19% of all studies registered on the … prediction performance of standard methods. In their work, they predict adverse drug reactions using output from LDA by using the “drug document” as the textual input. Here, topics had the useful interpretation of biochemical mechanisms …

Medication Adherence

Phenomics Health Inc. Acquires Patented Pharmacometabolomic Technology | Business & Finance | manchestertimes.com | Business Wire | 11/22/2019

… said Dr. James S. Burns, co-founder, Chairman and President, Phenomics Health. “PrecīsMed could help improve patient treatment outcomes, avoid adverse drug reactions, and reduce patient treatment costs – the real definition of precision medicine.” Current … 2018 have demonstrated that PrecīsMed can accurately assess prescribing trends, medication adherence and electronic health record (EHR) coverage, as well as define medication concentrations in patients with comorbid disorders. 6 Phenomics Health also plans to …

Population Health

Phenomics Health Inc. Acquires Patented Pharmacometabolomic Technology | Business & Finance | manchestertimes.com | Business Wire | 11/22/2019

… said Dr. James S. Burns, co-founder, Chairman and President, Phenomics Health. “PrecīsMed could help improve patient treatment outcomes, avoid adverse drug reactions, and reduce patient treatment costs – the real definition of precision medicine.” Current … medications, drug combinations and doses that improve individual patient and population health outcomes while reducing adverse drug reactions. Discoveries from the University of Michigan Medical School, leading to exclusive licensed proprietary informatics technology, form the …

Precision Medicine

Phenomics Health Inc. Acquires Patented Pharmacometabolomic Technology | 11/22/2019

Blog This Phenomics Health Inc. , a bioinformatics platform-based precision medicine company, today announced it has acquired the patented pharmacometabolomic technology portfolio of Precera Bioscience, based in Franklin, Tenn. Phenomics Health plans to integrate the … Phenomics Health. “PrecīsMed could help improve patient treatment outcomes, avoid adverse drug reactions, and reduce patient treatment costs – the real definition of precision medicine.” Current Medication Therapy Remains Ineffective Studies have found that 33% of …

Clinical Pharmacology

VUMC’s Roden wins Schottenstein Prize | 11/20/2019

Clinical Pharmacology and later as a fellow in cardiology. Roden has since become internationally recognized for his studies of the mechanisms and treatment of abnormal heart rhythms and variability in drug response. One major interest has been pharmacogenomics – and especially the role genetic variations play in adverse drug reactions such as drug-induced arrhythmias. Roden directed the Division of Clinical Pharmacology 1992-2004 when he became founding director of the Oates …

Electronic Medical Record

VUMC’s Roden wins Schottenstein Prize | 11/20/2019

… rhythms and variability in drug response. One major interest has been pharmacogenomics – and especially the role genetic variations play in adverse drug reactions such as drug-induced arrhythmias. Roden directed the Division of Clinical Pharmacology … co-principal investigator for the VUMC site of the NIH Electronic Medical Records and Genomics Network and is principal investigator for the medical center’s DNA databank, BioVU. Pediatric Society award goes to VUMC’s Edwards Kathryn …

Clinical Care

Adaptation of potentially preventable medication-related hospitalisation indicators for indigenous populations in Australia using a modified Delphi technique | BMJ | 11/20/2019

… adverse drug reactions. However other MRPs are potentially preventable, for example, where clinical care preceding the hospitalisation event is not in accordance with accepted clinical guidelines. Potentially preventable medication-related hospitalisations (PPMRHs) are the result of a proportion of serious MRPs. 8 Clinical indicators have been developed and used in a number of countries to measure PPMRHs which link suboptimal care involving medication use with subsequent hospitalisation. 9–11 However …

Antibiotic Stewardship

ASP Scan (Weekly) for Nov 15, 2019 | 11/18/2019

ASP Scan (Weekly) for Nov 15, 2019 Dental antibiotic stewardship Antibiotic use, resistance in Europe ; Candida auris in NY hospitals ; Antibiotic prescribing drop in Finland ; Improper antibiotic Rx in Japan ; C diff in VA hospitals … address guidelines and controversies and to improve knowledge gaps about adverse drug reactions, and should provide education to dentists and orthopedic surgeons via webinars. They also suggest that dentists and orthopedic surgeons in the same …

Diagnostic Tests

ASP Scan (Weekly) for Nov 15, 2019 | 11/18/2019

… coordinators should meet with local orthopedic and dental societies to address guidelines and controversies and to improve knowledge gaps about adverse drug reactions, and should provide education to dentists and orthopedic surgeons via webinars. They … Burlingame, California, for developing three point-of-care host-response diagnostic tests to distinguish viral infections from bacterial ones, HHS said in a news release yesterday. The tests—HostDx Fever, HostDx Sepsis, and HostDx FeverFlu …

Department of Health and Human Services

ASP Scan (Weekly) for Nov 15, 2019 | 11/18/2019

… coordinators should meet with local orthopedic and dental societies to address guidelines and controversies and to improve knowledge gaps about adverse drug reactions, and should provide education to dentists and orthopedic surgeons via webinars. They … response rapid tests to diagnose viral, bacterial illnesses The US Department of Health and Human Services (HHS) will provide an initial $6 million over 14 months to Inflammatix, of Burlingame, California, for developing three point …

Clinical Data

FLUOXETINE (fluoxetine hydrochloride) capsule [Proficient Rx LP] | National Institutes of Health | 11/15/2019

… vaginal bleeding, and violent behaviors 1 . 1 These terms represent serious adverse events, but do not meet the definition for adverse drug reactions. They are included here because of their seriousness. As with all drugs … psychomotor performance decrement due to increased alprazolam levels. Antipsychotics — Some clinical data suggests a possible pharmacodynamic and/or pharmacokinetic interaction between SSRIs and antipsychotics. Elevation of blood levels of haloperidol and clozapine has been observed …

Mental Health

Impact of clinical pharmacist’s interventions on pharmacotherapy management in elderly patients on polypharmacy with mental health problems including quality of life: A prospective non-randomized study | Nature | 11/14/2019

Mental health problems (MHPs) are very common in the elderly and can have an important influence on their quality of life (QoL). There is almost no data on the impact of clinical pharmacists’ (CPs) interventions … can lead to many important drug-drug interactions (DDIs) and adverse drug reactions (ADRs). This can lead to treatment failure and increased care costs. A 2006 study of elderly residents in Slovenian nursing homes reports …

Pain Management

MORPHINE SULFATE injection [Civica, Inc.] | National Institutes of Health | 11/12/2019

… analgesics, opioids on an as needed basis and/or combination products, and chronic opioid therapy in a progressive plan of pain management such as outlined by the World Health Organization, the Agency for Healthcare Research … pathology. Clinicians should maintain a high index of suspicion for adverse drug reactions when evaluating altered mental status or movement abnormalities in patients receiving this modality of treatment. 5.8 Hypotensive Effect Morphine sulfate injection may …

American Society of Clinical Oncology

U.S. Food and Drug Administration Accepts for Priority Review Bristol-Myers Squibb’s Application for Opdivo (nivolumab) Plus Yervoy (ipilimumab) Combination for Patients with Previously Treated Advanced Hepatocellular Carcinoma | Business Wire | 11/11/2019

… Oncology combination in patients with advanced HCC previously treated with sorafenib. Data from this study were presented at the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting. The FDA’s Breakthrough Therapy Designation is a … patients receiving OPDIVO. The most frequent Grade 3 and 4 adverse drug reactions reported in 2% to 5% of patients receiving OPDIVO were abdominal pain, hyponatremia, increased aspartate aminotransferase, and increased lipase. In Checkmate 066 …

Medical Imaging

Life Molecular Imaging and ITELPHARMA Announce a Strategic Partnership for Supply and Production of NeuraCeq in Puglia, Italy | PRWeb | 11/11/2019

… patients and health care workers from unintentional radiation exposure. Most Common Adverse Reactions In clinical trials, the most frequently observed adverse drug reactions in 1077 subjects with 1295 NeuraCeq™ administrations were injection/application site erythema … Group owns Alliance Medical Group, the leading independent provider of medical imaging services within Europe, operating across 10 international countries. Life Healthcare also owns Scanmed S.A. (Poland) which provides healthcare and medical services in 20 …

Medical Education

Women may be more likely to have penicillin allergy | 11/10/2019

HOUSTON — Women were more likely to have positive penicillin skin test results than men, according to findings presented at the American College of Asthma, Allergy & Immunology Scientific Meeting. Dayne Voelker, MD, of the Mayo Clinic School of Graduate Medical Education, explained during a presentation that previous studies have shown that women are more likely to have asthma and anaphylaxis, and that “women are at increased risk for adverse drug reactions

Clinical Decision Support

Merits, features, and desiderata to be considered when developing electronic health records with embedded clinical decision support systems in Palestinian hospitals: a consensus study | 11/8/2019

… like “computerized”, “electronic”, “patient”, “inpatient”, “medical”, “health”, “hospital”, “record”, “profile”, “chart”, “prescribing”, “e-prescribing”, “e-health”, “e-prescription”, “medicine”, “medication”, “clinical decision support”, “embedded”, “integrated”, “incorporated”, “coupled”, “features”, “entry”, “information”, “evaluation”, “safety”, “assessment”, “review”, and … reports, co-morbidities, prescription and non-prescription medications, allergies, and adverse drug reactions. Such features might improve diagnostic accuracy [ 35 , 42 , 48 , 51 ], effectiveness of medication review and patient care [ 36 , 37 , 38 , 46 ], improve …

Novartis

Machine Learning Method Identifies Adverse Drug Side Effects | HealthIT Analytics | 6/24/2020

… to drug compounds at the molecular level, a study published in EBioMedicine revealed. Researchers from Harvard Medical School and the Novartis Institutes for BioMedical Research developed the machine learning algorithm to offer a new way … trouble early on and develop safer drugs in the future.” Adverse drug reactions can range from mild to fatal, the researchers noted. Effects can occur either when taking a drug as prescribed or as a …

OneOme

Family Care Path Partners With OneOme To Add Pharmacogenomic Testing To Its Genetic Wellness Program | PR Newswire | 12/2/2019

… brings applications benefiting people to the healthcare market, today announced a new partnership with Minneapolis -based pharmacogenomic (PGx) solutions company, OneOme, LLC . Through this partnership, Family Care Path will be offering OneOme’s RightMed® Test to … and error in the prescribing process, decrease the likelihood of adverse drug reactions and reduce potential healthcare costs. And only individuals most likely to benefit from pharmacogenomic testing will actually be tested, using OneOme’s proprietary …

Boehringer Ingelheim

VIRAMUNE (nevirapine) tablet, extended release [Boehringer Ingelheim Pharmaceuticals, Inc.] | National Institutes of Health | 11/19/2019

… STRENGTHS VIRAMUNE XR Tablets:400 mg, yellow, oval, biconvex extended-release tablets, debossed with “V04” on one side and the Boehringer Ingelheim logo on the other side. 4  CONTRAINDICATIONS VIRAMUNE XR is contraindicated: in patients … 1100.1486 are shown in Table 1. Table 1 Selected Clinical Adverse Drug Reactions of at least Moderate Intensity (Grade 2 or above) Occurring in 2% or more of Adult Subjects- Week 96 Analysis of Trial …

Amgen

Immunomodulators Market To Reach USD 239.7 Billion By 2026 | Reports And Data | Globe Newswire | 11/13/2019

… of disease progression. In spite of these advances, they are also associated with substantial medication-safety issues. The possibility of adverse drug reactions, serious drug-related difficulties, and medication errors is important. Pharmacists must be … 4.1% respectively Key market players include Hoffmann-La Roche Ltd., Amgen Inc., Abbott Laboratories, Johnson & Johnson, Novartis AG, and Bristol-Myers Squibb Company, among several others, constituting a competitive Immunomodulators industry To identify the key …

Bristol-Myers

U.S. Food and Drug Administration Accepts for Priority Review Bristol-Myers Squibb’s Application for Opdivo (nivolumab) Plus Yervoy (ipilimumab) Combination for Patients with Previously Treated Advanced Hepatocellular Carcinoma | Business Wire | 11/11/2019

PRINCETON, N.J.- Bristol-Myers Squibb Company (NYSE: BMY) today announced that the U.S. Food and Drug Administration (FDA) has accepted its supplemental Biologics License Application (sBLA) and granted Breakthrough Therapy Designation for Opdivo (nivolumab) in … patients receiving OPDIVO. The most frequent Grade 3 and 4 adverse drug reactions reported in 2% to 5% of patients receiving OPDIVO were abdominal pain, hyponatremia, increased aspartate aminotransferase, and increased lipase. In Checkmate 066 …

Bristol-Myers Squibb

U.S. Food and Drug Administration Accepts for Priority Review Bristol-Myers Squibb’s Application for Opdivo (nivolumab) Plus Yervoy (ipilimumab) Combination for Patients with Previously Treated Advanced Hepatocellular Carcinoma | Business Wire | 11/11/2019

PRINCETON, N.J.- Bristol-Myers Squibb Company (NYSE: BMY) today announced that the U.S. Food and Drug Administration (FDA) has accepted its supplemental Biologics License Application (sBLA) and granted Breakthrough Therapy Designation for Opdivo (nivolumab) in … patients receiving OPDIVO. The most frequent Grade 3 and 4 adverse drug reactions reported in 2% to 5% of patients receiving OPDIVO were abdominal pain, hyponatremia, increased aspartate aminotransferase, and increased lipase. In Checkmate 066 …

Bausch Health

Bausch + Lomb Announces New Scientific And Clinical Analyses To Be Presented During The American Academy Of Ophthalmology And American Academy Of Optometry Annual Meetings | PR Newswire | 10/7/2019

BRIDGEWATER, N.J. , Oct. 7, 2019 /PRNewswire/ – Bausch + Lomb, a leading global eye health company and wholly owned subsidiary of Bausch Health Companies Inc. (NYSE/TXS: BHC), today announced that 14 new scientific poster and clinical … when the eyes are inflamed. There were no treatment-emergent adverse drug reactions that occurred in more than 1% of subjects in the three times daily group compared to vehicle. You are encouraged to report …

Bausch Health Companies

Bausch + Lomb Announces New Scientific And Clinical Analyses To Be Presented During The American Academy Of Ophthalmology And American Academy Of Optometry Annual Meetings | PR Newswire | 10/7/2019

BRIDGEWATER, N.J. , Oct. 7, 2019 /PRNewswire/ – Bausch + Lomb, a leading global eye health company and wholly owned subsidiary of Bausch Health Companies Inc. (NYSE/TXS: BHC), today announced that 14 new scientific poster and clinical … when the eyes are inflamed. There were no treatment-emergent adverse drug reactions that occurred in more than 1% of subjects in the three times daily group compared to vehicle. You are encouraged to report …

Eli Lilly

Elsevier Joins Forces with Pharmaceutical Industry Leaders to Build new Drug-Drug Interaction Risk Calculator | PR Newswire | 9/11/2019

Eli Lilly and Company, Pierre Fabre , Sanofi, Servier, and others to develop a new and improved drug–drug interaction risk calculator (DDIRC). The updated DDIRC will help DMPK (Drug Metabolism-Pharmacokinetic) and clinical pharmacology scientists improve patient safety and outcomes and reduce risk during pharmaceutical development. Adverse drug reactions (ADRs) are a serious problem worldwide. In Europe , 197,000 deaths per year are attributed to them, while the FDA estimates that …

Pfizer

Analysis on the Global Hormone Replacement Therapy Market 2019-2024 - Abbott, Bayer, Merck, Novartis, and Pfizer Hold the Largest Shares - ResearchAndMarkets.com | Business Wire | 6/18/2019

… blood clots, and some cases of cancer. These side effects have been well documented in the form of moderate-severe adverse drug reactions (ADRs). These ADRs are expected to cause some erosion in the popularity … the largest market share are Abbott, Bayer, Merck, Novartis, and Pfizer. However, there are efforts being made by new players to enter the hormone replacement therapy market. Key Topics Covered 1 INTRODUCTION 1.1 Study Deliverables …

Seattle Genetics

Takeda to Showcase Growing Pipeline and Diversified Portfolio of Oncology Products at Upcoming Scientific Congresses | Business Wire | 5/16/2019

… III and IV Hodgkin lymphoma and in CD30+ peripheral T-cell lymphoma, respectively, will also be shared in partnership with Seattle Genetics. At EHA, additional analyses from the TOURMALINE-MM3 trial, which is investigating NINLARO … pruritus, constipation, dyspnoea, weight decreased, myalgia and abdominal pain. Serious adverse drug reactions occurred in 12% of patients. The frequency of unique serious adverse drug reactions was ≤1%. Adverse events led to treatment discontinuation in …

Loxo Oncology

Bayer Data at ASCO 2019 Highlights Commitment to Evolving the Cancer Treatment Paradigm | PR Newswire | 5/13/2019

… for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials. Following the acquisition of Loxo Oncology by Eli Lilly and Company in February 2019 , Bayer has obtained the exclusive … and for at least one month after the last dose. Adverse Drug Reactions : Serious adverse reactions were reported in 44 (26%) patients. The most frequent serious adverse reactions that occurred were pneumonia (8%), pneumonitis (5 …

Optum

Global Pharmacovigilance Market Forecast 2018-2028 | PR Newswire | 1/9/2018

… Corporation (Oracle) - Bristol-Myers Squibb Company - HCL Technologies Ltd. - Olympus Corporation • Moreover, this report discusses the following: - Reporting systems for adverse drug reactions (ADRs) - their present and future, including data on reported and recorded events … NDA Group Nhumi Technologies Novartis November Research Group Novo Nordisk Optum Oracle Orbis Clinical ParagonRX Parexel PatientsLikeMe Patni Computer Systems Paul Ehrlich Institute Pfizer PharSafer PPD PRA International Primevigilance Quanticate Quantum Solutions India Quintiles Transnational …

ViiV Healthcare

Janssen Announces U.S. FDA Approval of First and Only Complete, Single-Pill, Two-Drug Regimen, JULUCA® (Dolutegravir and Rilpivirine), for the Treatment of HIV-1 Infection | PR Newswire | 11/22/2017

… are virologically suppressed. JULUCA ® is a once-daily, antiretroviral combination of dolutegravir, an integrase strand transfer inhibitor (INSTI) marketed by ViiV Healthcare as TIVICAY ® , and rilpivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) marketed by … been conducted in pregnant women Adverse Reactions The most common adverse drug reactions reported (incidence 2%) of at least moderate intensity (≥ Grade 2) in patients taking EDURANT ® through 96 weeks were depressive disorders (5%), headache …

CVS Caremark

Solutions to PBM Pricing Abuses Must Address Entire Drug Supply Chain | PR Newswire | 10/17/2017

… from one part of the pricing system to another.” The SCPC leader pointed out that the nation’s three major PBMs — CVS Caremark, Express Scripts and Optum Rx — control more than 80% of prescriptions dispensed in … antibiotic stewardship and various other consulting services designed to minimize adverse drug reactions, polypharmacy complications, overuse of antibiotics and more generally improve patient outcomes. These obligations derive first and foremost from professional responsibility, but are …

Daiichi Sankyo

Daiichi Sankyo’s VANFLYTA® Receives Approval in Japan for the Treatment of Relapsed/Refractory FLT3-ITD AML | PR Newswire | 6/18/2019

TOKYO , MUNICH and BASKING RIDGE, N.J. Daiichi Sankyo Company, Limited (hereafter, Daiichi Sankyo) announced today that the Ministry of Health, Labor and Welfare (MHLW) of Japan has approved VANFLYTA ® (quizartinib), an oral FLT3 inhibitor, for … months [4.0, 5.5] salvage chemotherapy. The most common treatment-related adverse drug reactions in those receiving VANFLYTA were nausea (33.2%, 80/241 patients), electrocardiogram QT prolonged (24.9%, 60/241 patients), anemia (24.9%, 60/241 patients), and thrombocytopenia (21.2 …

Daiichi Sankyo Announces Outcome of FDA Oncologic Drugs Advisory Committee Meeting to Review FLT3 Inhibitor Quizartinib for the Treatment of Patients with Relapsed/Refractory FLT3-ITD AML | Markets Insider | Business Insider | 5/14/2019

TOKYO and BASKING RIDGE, N.J. , May 14, 2019 /PRNewswire/ – Daiichi Sankyo Company, Limited (hereafter, Daiichi Sankyo) today announced the outcome of the U.S. Food and Drug Administration (FDA) Oncologic Drugs Advisory Committee (ODAC) to discuss … quizartinib and those who received salvage chemotherapy. The most common adverse drug reactions ( 30 percent, any Grade) in patients treated with quizartinib included infections, bleeding, nausea, asthenic conditions, pyrexia, febrile neutropenia, and vomiting, and the …

Mayo Clinic

Family Care Path Partners With OneOme To Add Pharmacogenomic Testing To Its Genetic Wellness Program | PR Newswire | 12/2/2019

… Mayo Clinic, that analyzes a person’s DNA to give doctors and pharmacists genetic information that may help them optimize medication selection for that person, minimize trial and error in the prescribing process, decrease the likelihood of adverse drug reactions and reduce potential healthcare costs. And only individuals most likely to benefit from pharmacogenomic testing will actually be tested, using OneOme’s proprietary population evaluation algorithm. “OneOme’s RightMed Test is an ideal …

Phenomics Health Inc. Acquires Patented Pharmacometabolomic Technology | Business & Finance | manchestertimes.com | Business Wire | 11/22/2019

… said Dr. James S. Burns, co-founder, Chairman and President, Phenomics Health. “PrecīsMed could help improve patient treatment outcomes, avoid adverse drug reactions, and reduce patient treatment costs – the real definition of precision medicine.” Current … per year 5,” according to a report published in the Mayo Clinic Proceedings . Patients who suffer from comorbid disorders often require treatments with multiple medications, which can result in missed, wrong, or multiple dosages. Additionally …

Kaiser Permanente

(USA-CA-Oakland) Inpatient Pharmacist | 12/1/2019

Job Information Kaiser Permanente Inpatient Pharmacist in Oakland , California Under indirect supervision consults with patients and medical personnel regarding medication therapy. Dispenses compounds, procures, stores, and distributes pharmacy products. Provides medical personnel and patients with … Reviews laboratory test results and the patient’s progress to detect adverse drug reactions, and confers with and assists medical personnel in laboratory test interpretation, care and treatment of patients. Interviews patients to obtain information regarding …

(USA-CA-San Diego) Ambulatory Care Pharmacist (PEM-7920) | 10/30/2019

Job Information Kaiser Permanente Ambulatory Care Pharmacist (PEM-7920) in San Diego , California Provides ambulatory pharmaceutical care services using approved protocols in collaboration with other health professional, including managing patient drug therapy, providing patient education … improper drug selection, subtherapeutic dosage, overdose, failure to receive medication, adverse drug reactions, drug interactions, and medication without indication. Under protocol, initiates, adjusts, monitors, and recommends changes in drug therapy based on information obtained through …

University Hospital

Association between potentially inappropriate medications at discharge and unplanned readmissions among hospitalised elderly patients at a single centre in Japan: a prospective observational study | BMJ | 11/7/2019

… hospital that is one of the largest acute care hospitals in Utsunomiya in Japan. This research was registered at the University Hospital Medical Information Network (UMIN) clinical registry on 29 April 2017. Inclusion and exclusion … 39–42 Furthermore, there were a few readmissions due to adverse drug reactions in this study (see the online supplementary table S3 ). Given that PIMs at discharge may be associated with medication-related readmissions rather …

Haemolytic disease of the fetus and newborn diagnosed after delivery of a baby to a mother with low anti-E antibody titres | BMJ | 9/9/2019

Unexpected outcome (positive or negative) including adverse drug reactions Case report Haemolytic disease of the fetus and newborn diagnosed after delivery of a baby to a mother with low anti-E antibody titres Tara T’Shieh Maey Lee 1 , Paul Clarke 2 and 1 Maternity Department , Norfolk and Norwich University Hospitals NHS Foundation Trust , Norwich , UK 2 Neonatal Intensive Care Unit , Norfolk and Norwich University Hospital , Norwich , UK Correspondence to Dr …

Memorial Sloan Kettering Cancer Center

TAIHO ONCOLOGY, INC.: Analysis of Patients with Prior Gastrectomy Treated with LONSURF® (trifluridine and tipiracil) Published in JAMA Oncology | 10/15/2019

… gastroesophageal junction adenocarcinoma have undergone a previous gastrectomy and are prone to more complications than those without gastrectomy,”1,2,3,4,5 said Memorial Sloan Kettering Cancer Center Medical Oncologist David H. Ilson, MD, PhD. “These data provide … 30 mL/min) were not studied. ADVERSE REACTIONS Most Common Adverse Drug Reactions in Patients Treated With LONSURF (≥5%): The most common adverse drug reactions in LONSURF‑treated patients vs placebo‑treated patients with mCRC, respectively, were …

Analysis of Patients with Prior Gastrectomy Treated with LONSURF® (trifluridine and tipiracil) Published in JAMA Oncology | BioSpace | 10/14/2019

… gastroesophageal junction adenocarcinoma have undergone a previous gastrectomy and are prone to more complications than those without gastrectomy,” 1,2,3,4,5 said Memorial Sloan Kettering Cancer Center Medical Oncologist David H. Ilson, MD, PhD. “These data provide … 30 mL/min) were not studied. ADVERSE REACTIONS Most Common Adverse Drug Reactions in Patients Treated With LONSURF (≥5%): The most common adverse drug reactions in LONSURF‑treated patients vs placebo‑treated patients with mCRC, respectively, were …

Ludger Dinkelborg

Life Molecular Imaging and ITELPHARMA Announce a Strategic Partnership for Supply and Production of NeuraCeq in Puglia, Italy | PRWeb | 11/11/2019

… with ITEL to better serve physicians and our pharma partners with our approved NeuraCeq™ for clinical routine and research,” said Ludger Dinkelborg, Ph.D., Managing Director at LMI. “We are very proud of this collaboration with … Common Adverse Reactions In clinical trials, the most frequently observed adverse drug reactions in 1077 subjects with 1295 NeuraCeq™ administrations were injection/application site erythema (1.7%), and injection site pain (3.4%). About Life Molecular Imaging …

Life Molecular Imaging and Positron Pharma announce a strategic partnership for manufacturing and distribution of PI-2620 in Chile | PRWeb | 10/14/2019

… physicians and our pharma partners with both, Neuraceq™ and the investigational PI-2620 tau PET tracer for clinical trials,” said Ludger Dinkelborg, Ph.D., Managing Director at LMI. About Neuraceq (florbetaben F18 injection) Indication Neuraceq™ (florbetaben … Common Adverse Reactions In clinical trials, the most frequently observed adverse drug reactions in 872 subjects with 1090 Neuraceq™ administrations were injection/application site erythema (1.7%), injection site irritation (1.1%), and injection site pain (3.4 …

Jonathan Stempel

U.S. says gene testing firm gets 25-year ban in $42.6 mln kickback settlement | Yahoo News | 10/10/2019

… offered kickbacks to other entities and individuals, and billed Medicare for unnecessary genetic tests. According to whistleblowers’ complaints, the “Diagnosing Adverse Drug Reactions Registry,” or DART trial, was intended to catalog the effects of genetic … issued a consumer alert concerning genetic testing fraud. (Reporting by Jonathan Stempel in New York; Editing by Bill Berkrot …

U.S. says gene testing firm gets 25-year ban in $42.6 million kickback settlement | Yahoo News | 10/10/2019

… offered kickbacks to other entities and individuals, and billed Medicare for unnecessary genetic tests. According to whistleblowers’ complaints, the “Diagnosing Adverse Drug Reactions Registry,” or DART trial, was intended to catalog the effects of genetic … issued a consumer alert concerning genetic testing fraud. (Reporting by Jonathan Stempel in New York; Editing by Bill Berkrot …

Fouad Namouni

Bristol-Myers Squibb Provides Update on Phase 3 Opdivo (nivolumab) CheckMate -548 Trial in Patients with Newly Diagnosed MGMT-Methylated Glioblastoma Multiforme | Business & Finance | heraldchronicle.com | Business Wire | 9/5/2019

… aggressive and difficult disease to treat. We look forward to seeing the overall survival data when they are available,” said Fouad Namouni, M.D., head, Oncology Development, Bristol-Myers Squibb. “We are grateful to the patients … patients receiving OPDIVO. The most frequent Grade 3 and 4 adverse drug reactions reported in 2% to 5% of patients receiving OPDIVO were abdominal pain, hyponatremia, increased aspartate aminotransferase, and increased lipase. In Checkmate 066 …

First Data for NKTR-214 in Combination with OPDIVO® (nivolumab) for Patients with Stage IV Melanoma, Renal Cell Carcinoma and Non-Small Cell Lung Cancers, Including Patients with PD-L1 Negative Status, Revealed at SITC 2017 | PR Newswire | 11/12/2017

… These initial findings underscore the potential benefit of the combination of Opdivo and NKTR-214 across several tumor types,” said Fouad Namouni, M.D., Head of Oncology Development, Bristol-Myers Squibb. “We believe that a combination … patients receiving OPDIVO. The most frequent Grade 3 and 4 adverse drug reactions reported in 2% to 5% of patients receiving OPDIVO were abdominal pain, hyponatremia, increased aspartate aminotransferase, and increased lipase. In Checkmate 066 …

Shannon Brown

Drugs Are Keeping Seniors Healthy, And Hurting Them | jeunesse founder | Forbes | 4/20/2019

… five or more medications each day, they can cause illness or even death. A new study by Judith Garber and Shannon Brownlee of the Lown Institute, estimate that as many as 10 million older adults … lives. Yet diabetes medications are among the leading causes of adverse drug reactions. If they lower blood sugar too much, they increase the risk of falls and confusion. Similarly, while blood thinners such as aspirin …

Drugs Are Keeping Seniors Healthy, And Hurting Them | Forbes | 4/8/2019

… five or more medications each day, they can cause illness or even death. A new study by Judith Garber and Shannon Brownlee of the Lown Institute, estimate that as many as 10 million older adults … lives. Yet diabetes medications are among the leading causes of adverse drug reactions. If they lower blood sugar too much, they increase the risk of falls and confusion. Similarly, while blood thinners such as aspirin …

Said Rosenbloom

Solutions to PBM Pricing Abuses Must Address Entire Drug Supply Chain | PR Newswire | 10/17/2017

… accurately identify the causes of problems and concerns, and will be unable to craft real and lasting solutions,” he continued. Said Rosenbloom: “The overall system is like a balloon – squeeze one area (e.g., DIR fees … antibiotic stewardship and various other consulting services designed to minimize adverse drug reactions, polypharmacy complications, overuse of antibiotics and more generally improve patient outcomes. These obligations derive first and foremost from professional responsibility, but are …

Solutions To PBM Pricing Abuses Must Address Entire Drug Supply Chain - TheStreet | 10/17/2017

… accurately identify the causes of problems and concerns, and will be unable to craft real and lasting solutions,” he continued. Said Rosenbloom: “The overall system is like a balloon - squeeze one area (e.g., DIR fees … antibiotic stewardship and various other consulting services designed to minimize adverse drug reactions, polypharmacy complications, overuse of antibiotics and more generally improve patient outcomes. These obligations derive first and foremost from professional responsibility, but are …